Patents by Inventor Colin Marshall
Colin Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110201736Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: ApplicationFiled: February 17, 2011Publication date: August 18, 2011Applicant: INNOVIA FILMS LIMITEDInventors: Alastair Hugh Servante, Gary Power, Colin Marshall
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Patent number: 7956183Abstract: A method for the synthesis of a diaminophenothiazinium compound of the following formula: comprising (a) purifying a corresponding reduced compound which is N-acylated at the heterocyclic nitrogen; (b) deacylating the purified compound to provide the corresponding reduced compound; and (c) oxidizing the reduced compound to provide the diaminophenothiazinium compound. Optional purification may performed, for example, after deacylating and after oxidizing. The method provides high purity diaminophenothiazinium compounds which are suitable for pharmaceutical and related therapeutic uses. Such uses include inactivating pathogens, the treatment of the infectious diseases, and for the treatment of diseases of protein aggregation, such as tauopathies, including Alzheimer's disease.Type: GrantFiled: July 10, 2007Date of Patent: June 7, 2011Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Publication number: 20110118242Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methylthioninium chloride, MTC).Type: ApplicationFiled: January 21, 2011Publication date: May 19, 2011Inventors: Claude Michel WISCHIK, Janet Elizabeth Rickard, Charles Robert Harrington, David Horsley, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Publication number: 20110100386Abstract: The present invention concerns an at least partially transparent cigarette filter tipping film comprising a biodegradable substrate, and softener in an amount of less than 25% by weight of the biodegradable substrate, and a cigarette filter comprising a filtration material encased in a cylinder of the said tipping film.Type: ApplicationFiled: August 11, 2010Publication date: May 5, 2011Applicant: Innovia Films LimitedInventors: Paul WATTERS, Colin Marshall
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Publication number: 20110094526Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres or films, and converting the fibres or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.Type: ApplicationFiled: September 29, 2010Publication date: April 28, 2011Applicant: INNOVIA FILMS LIMITEDInventors: Colin MARSHALL, Jamie MOFFAT
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Patent number: 7888350Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).Type: GrantFiled: March 28, 2007Date of Patent: February 15, 2011Assignee: Wista Laboratories Ltd.Inventors: Claude Michel Wischik, Janet Elizabeth Rickard, Charles Robert Harrington, David Horsley, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Publication number: 20110021510Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.Type: ApplicationFiled: September 3, 2010Publication date: January 27, 2011Inventors: John Mervyn David STOREY, James Peter SINCLAIR, Colin MARSHALL, Han Wan TAN, Claude Michel WISCHIK
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Publication number: 20100267301Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: ApplicationFiled: June 8, 2010Publication date: October 21, 2010Applicant: INNOVIA FILMS LIMITEDInventors: Alastain Hugh SERVANTE, Gary Power, Colin Marshall
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Patent number: 7790881Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.Type: GrantFiled: September 21, 2005Date of Patent: September 7, 2010Assignee: Wista Laboratories Ltd.Inventors: John Mervyn David Storey, James Peter Sinclair, Colin Marshall, Han Wan Tan
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Patent number: 7758965Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: GrantFiled: October 22, 2004Date of Patent: July 20, 2010Assignee: Innovia Films LimitedInventors: Alastair Hugh Servante, Gary Power, Colin Marshall
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Publication number: 20100173145Abstract: The present invention concerns a functional film material comprising a substrate layer and a coating layer, the coating layer comprising a block copolymeric binder and a particulate metal pigment therein, the ratio of pigment to binder in the coating layer being selected with reference to the coat weight to provide the functional film material with an emissivity of less than 0.5, and the substrate and coating layer being selected to provide the film with a VWTR (ambient) in excess 400 gm?2d?1 bar?1.Type: ApplicationFiled: May 21, 2008Publication date: July 8, 2010Applicant: INNOVIA FILMS LIMITEDInventors: Colin Marshall, Paul Watters
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Patent number: 7737138Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.Type: GrantFiled: March 29, 2006Date of Patent: June 15, 2010Assignee: Wista Laboratories Ltd.Inventors: Claude M. Wischik, Janet E. Rickard, Charles R. Harrington, David Horsley, John M. D. Storey, Colin Marshall, James P. Sinclair, Han Wan Tan
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Publication number: 20090259040Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesis and/or purification of certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment, prophylaxis, and diagnosis, etc.Type: ApplicationFiled: July 10, 2007Publication date: October 15, 2009Inventors: Claude Michel Wischik, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Publication number: 20090054419Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).Type: ApplicationFiled: March 28, 2007Publication date: February 26, 2009Inventors: Claude Michel Wischik, Janet Elizabeth Rickard, Charles Robert Harrington, David Horsley, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Publication number: 20080207603Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.Type: ApplicationFiled: September 21, 2005Publication date: August 28, 2008Inventors: John Mervyn David Storey, James Peter Sinclair, Colin Marshall, Han Wan Tan, Claude Michel Wischik
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Publication number: 20060287523Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.Type: ApplicationFiled: March 29, 2006Publication date: December 21, 2006Inventors: Claude Wischik, Janet Rickard, Charles Harrington, David Horsley, John Storey, Colin Marshall, James Sinclair, Han Tan
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Publication number: 20060124239Abstract: There is described a method of applying a transparent label of polymeric film to an article to produce a labelled article having a substantial no-label appearance. Labelled articles and labels suitable for use in this method are also described. The labelling method comprises the steps of: (a) selecting films having the following properties (i) Cobb5min value (measured over 5 minutes) from 0.25 to 50 gm?2(min.)?1; and (ii) water vapour transmission rate under tropical conditions from 5 to 2000 gm?2(24 hr)?1, (b) selecting a liquid adhesive (such as a wet glue) having a viscosity from 1 to 500 Pa·s; and (c) applying the selected adhesive to fix the selected label film to the article where the thickness of the adhesive layer between the article and label on application thereof is from 25 to 150 microns. Preferred labels are clear or coloured laminated cellulose films selected to have Cobb5min from 1.25 to 15 gm?2(min.)?1 and WVTRtrop from 325 to 875 gm?2(24 hr)?1.Type: ApplicationFiled: February 9, 2004Publication date: June 15, 2006Inventors: Colin Marshall, Darren Nash, Peter Mills
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Publication number: 20050112334Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: ApplicationFiled: October 22, 2004Publication date: May 26, 2005Inventors: Alastair Servante, Gary Power, Colin Marshall
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Publication number: 20040234862Abstract: There is described a battery separator comprising: a porous membrane (preferably of a cellulose film) having a mean thickness less than about 25 microns (preferably 15 microns) and optionally with one or more of the following properties: a) a tensile strength when dry (measured in the transverse direction of the membrane web) of greater than about 120 Nmm−2; b) a wet ionic resistance of less than about 20 m&OHgr;.cm2; c) a membrane degree of polymerisation (D.P.) of greater than 350 chain units after being immersed for four hours in a bath of sodium hydroxide and hydrogen peroxide; and/or a) a tensile strength when dry (measured in the machine direction of the membrane web) of greater than about 200 Nmm−2. Preferred membranes comprise biopolymeric films, such as films derived from cellulose and/or polylactic acid, more preferably a regenerated cellulosic film made using NMMO as regeneration liquid.Type: ApplicationFiled: February 23, 2004Publication date: November 25, 2004Inventors: Graham Macglashan, Colin Marshall, Simon Read
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Publication number: 20020185804Abstract: Image recording apparatus for recording an image on a recording plate, the apparatus comprisingType: ApplicationFiled: June 3, 2002Publication date: December 12, 2002Applicant: FUJIFILM ELECTRONIC IMAGING LIMITEDInventors: James Buckingham Wood, Colin Marshall, Stephen Edward Fox