Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract: A waterborne coating composition includes an aqueous polyurethane resin, a reactive silicone component, and a crosslinker. The aqueous polyurethane resin can have urethane linkages, hydrazinecarboxamide linkages, and reactive hydrazide functional groups. The polyurethane resin can have a glass transition temperature of less than 25° C. Methods of preparing waterborne coating compositions and substrates at least partially coated with waterborne coating compositions are also disclosed.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: A method for determining the position and its statistical uncertainty of a fission semi-track in a crystal based on detecting the tip and etch figure of a fission semi-track in a series of transmitted light images. A computer software program for: detecting the tip and etch figure of a fission semi-track in a series of transmitted light images and assessing the viability of the tip using a scoring equation; writing to and loading from a computer database of fission semi-tracks; modifying the scoring equation for assessing fission semi-track tip viability based on the contents of the computer database. A computer database consisting of transmitted light images of fission semi-tracks. A method for determining the statistical probability that a fission semi-track is a real fission semi-track.

Abstract: A method for determining the position and its statistical uncertainty of a confined fission track in a crystal based on detecting confined fission track tips in a series of transmitted light images. A computer software program for: detecting confined fission track tips in a series of transmitted light images and assessing the viability of each tip using a scoring equation; writing to and loading from a computer database of confined fission tracks; modifying the scoring equation for assessing confined fission track tip viability based on the contents of the computer database. A computer database consisting of transmitted light images of confined fission tracks. A method for determining the statistical probability that a confined fission track is a real confined fission track.

Abstract: A tie article that includes an attachment portion and a bib portion, where the bib portion includes at least one arm segment and at least one closure device (e.g., a retention wire, tin tie, clasp tie, and the like), where the attachment portion and the bib portion are integrally fabricated from a printed sheet having a first surface and a polymeric film adhered to the first surface of the printed sheet such that the closure device(s) is disposed between the first surface of the printed sheet and the polymeric film at the attachment portion. Multiple tie articles may be manufactured with an in-line process.

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract: According to one aspect, embodiments of the invention provide a reactive display system comprising a display channel, data storage coupled to the display and configured to store pre-determined and reactive messages, a sensor configured to monitor at least one variable of an area within which the system is located, and a controller coupled to the sensor, data storage and the display, wherein the controller is configured to operate data storage and the display channel to display at least one pre-determined message in a first mode of operation, and wherein the controller is further configured to operate data storage and the display channel to display at least one reactive message in a second mode of operation in response to an indication from the sensor that the at least one variable has changed.

Abstract: Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.

Abstract: A display unit comprising of at least one display sheet of a substantially rigid and foldable material divided into a plurality of panels by crease and/or score lines that when erected forms a display unit with at least one concave presentation face.

Abstract: According to one aspect, embodiments of the invention provide a system for providing user specific content, the system comprising a WIFI access node configured to be coupled to an external network and to receive a hardware address of at least one local mobile device attempting to connect to the external network via the WIFI access node, a content management system coupled to the WIFI access node, and a public channel coupled to the WIFI access node, wherein the content management system is configured to provide content related to a user of the at least one local mobile device to the public channel in response to the WIFI access node receiving the hardware address of the at least one local mobile device, and wherein the public channel is configured to display the content related to the user.

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract: A medical procedure localization aid produces reference marks on both the patient and the medical imaging scan. The aid is defined by a substrate sheet having indicia on one side that is opaque to medical imaging radiation and indicia on a second side that is transferable to a patient. The indicia on the first side is displayed on the scan image and the indicia on the second side is imprinted on the patient. By visualizing the location of a target on the scan image relative to the indicia on the scan image and comparing that with indicia on the patient, a medical professional may reliably locate where a medical procedure should be performed.

Abstract: A game device (1) comprises a ball (2) and twelve indicators (3). Each indicator (3) comprises a suction cavity (4) and a release ring (5). Each indicator (3) may be releasably attached by suction to the ball (2) by manipulating the suction cavity (4) of the indicator (3) to create a suction force between the indicator (3) and the ball (2). The release ring (5) protrudes from the ball (2) substantially perpendicular to an external surface of the ball (2). Upon an impact to the release ring (5), for example a user kicking the device (1), the release ring (5) acts to release the suction attachment force between the indicator (3) and the ball (2). The indicator (3) thus becomes detached from the ball (2). By detaching the indicator (3) from the ball (2), the indicator (3) acts to indicate the region of the impact to the game device (1).

Abstract: A display unit comprising of at least one display sheet of a substantially rigid and foldable material divided into a plurality of panels by crease and/or score lines that when erected forms a display unit with at least one concave presentation face.

Abstract: A skateboard is disclosed that includes a rear wheel system and a front wheel system. The rear wheel system includes a pair of rear wheels that are mounted on a rear axle that is coupled to a rear truck that is attached to an underside of a rear portion of a board. The rear wheel system permits each of the pair of rear wheels to alternately move toward a front portion of the board responsive to a force alternately urging each of the pair of rear wheels toward the underside of the board. The front wheel system includes a pair of front wheels that are mounted on a front axle that is rotatably attached to a mid-truck such that the front axle is movable about a first axis of rotation. The mid-truck is rotatably attached to an attachment base that is secured to an underside of the front portion of the board such that the mid-truck is rotatable about a second axis of rotation.