Abstract: A current configuration of one or more data management services is monitored. It is determined that the current configuration is insufficient to achieve a data protection intent indicated by a specification of the data protection intent. In response to determining that the current configuration is insufficient to achieve the data protection intent indicated by the specification of the data protection intent, the current configuration of the one or more data management services is modified in a manner to achieve the data protection intent indicated by the specification of the data protection intent.

Abstract: Monk fruit extracts containing mogrol glycosides such as mogroside V may be treated with enzymes under specific reaction conditions to shift distribution of the Siamenoside I reaction product. Modified enzymes are also employed to shift Siamenoside I distribution to increase yield of Siamenoside I and reduce reaction contaminants. Methods of purifying bioconversion reaction product are also described. Siamenoside I obtained using these methods is a useful sweetener and flavor enhancer for food and beverage compositions and the like.

Abstract: One or more event logs are received. The one or more event logs are analyzed using a plurality of models to detect one or more anomalous events. A graphical representation of risk entities associated with at least one of the one or more detected anomalous events is provided. A visual representation of automatically detected relationships between the risk entities associated with the at least one of the one or more detected anomalous events is provided in the graphical representation. Indications of measures of anomaly associated with detected anomalous events are provided for the associated risk entities.

Abstract: One or more event logs are received. The one or more event logs are analyzed using a plurality of models to detect one or more anomalous events. A graphical representation of risk entities associated with at least one of the one or more detected anomalous events is provided. A visual representation of automatically detected relationships between the risk entities associated with the at least one of the one or more detected anomalous events is provided in the graphical representation. Indications of measures of anomaly associated with detected anomalous events are provided for the associated risk entities.

Abstract: A current configuration of one or more data management services is monitored. It is determined that the current configuration is insufficient to achieve a data protection intent indicated by a specification of the data protection intent. In response to determining that the current configuration is insufficient to achieve the data protection intent indicated by the specification of the data protection intent, the current configuration of the one or more data management services is modified in a manner to achieve the data protection intent indicated by the specification of the data protection intent.

Abstract: An apparatus and method for creating axial movement of an inner sliding sleeve member on a tool in a downhole environment. The apparatus has keys which mate in a profile on the inner sliding sleeve member, the keys being held in a carrier on a sleeve around an inner mandrel. The inner mandrel includes stops and a lip which can be slid over the keys to retract them for release from the inner sliding sleeve member. By picking up and shifting down the mandrel relative to the sleeve, the apparatus is cycled to jar up, jar down and release. An exercise tool to release a stuck flow tube of a subsurface safety valve is described.

Abstract: The present disclosure provides methods for producing gene-edited cells free of gene-editing system molecules through the manipulation of prototrophy. Exemplary system molecules include those required for CRISPR editing techniques, such as plasmids and genes encoding Cas nucleases. The methods may employ constructs that temporarily disrupt prototrophy, the removal of which restores prototrophy. Also disclosed are gene-edited cells and populations of gene-edited cells comprising these constructs. The present methods and compositions may be used to achieve desired gene editing of a host cell in the absence of extraneous genetic material remaining from the genetic engineering technique itself.

Abstract: A specification of a data protection intent is received. Configurations for a plurality of different data management services are automatically determined in an attempt to achieve the specified data protection intent. The determined configurations in the plurality of different data management services are automatically implemented.

Abstract: Method and apparatus for creating a fluid communication line in a downhole environment between an annular chamber and a throughbore of a tool. The tubular wall therebetween is provided with circumferentially arranged recesses extending into the wall to provide selected thin-walled sections for perforation by a communication tool. The communication tool has two oppositely arranged punch heads, one aligned with a recess and the other between neighbouring recesses giving an orientationless configuration in operation. An embodiment for creating a fluid communication line through a tubing retrievable safety valve for operation of a wireline retrievable safety valve located therein is described.

Abstract: Provided herein are nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals as well as expression vectors and compositions comprising the same. Also provided herein are methods for assembling the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals in a pooled and/or modular manner. Methods for using the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals to facilitate multiplexed genomic editing of a host cell comprising said nucleic acid constructs are also provided herein.

Abstract: One or more event logs are received. The one or more event logs are analyzed using a plurality of models to detect one or more anomalous events. A graphical representation of risk entities associated with at least one of the one or more detected anomalous events is provided. A visual representation of automatically detected relationships between the risk entities associated with the at least one of the one or more detected anomalous events is provided in the graphical representation. Indications of measures of anomaly associated with detected anomalous events are provided for the associated risk entities.

Abstract: An indication of an instantiation of a first graphical user interface item representing a first data pool component being specified to be included in a data pool is received. An indication of an instantiation of a second graphical user interface item representing a second data pool component being specified to be included in the data pool is received. The second graphical user interface item is graphically instantiated as connected with the first graphical user interface item to indicate that the first data pool component and the second data pool component belong to the same data pool able to be referenced as a combined single data entity. An indication of an instantiation of a third graphical user interface item representing a data management action to be applied to the data pool, wherein the third graphical user interface item is graphically instantiated as connected with a graphical representation of the data pool is received.

Abstract: An apparatus and method for creating axial movement of an inner sliding sleeve member on a tool in a downhole environment. The apparatus has keys which mate in a profile on the inner sliding sleeve member, the keys being held in a carrier on a sleeve around an inner mandrel. The inner mandrel includes stops and a lip which can be slid over the keys to retract them for release from the inner sliding sleeve member. By picking up and shifting down the mandrel relative to the sleeve, the apparatus is cycled to jar up, jar down and release. An exercise tool to release a stuck flow tube of a subsurface safety valve is described.

Abstract: Monk fruit extracts containing mogrol glycosides such as mogroside V may be treated with enzymes under specific reaction conditions to shift distribution of the Siamenoside I reaction product. Modified enzymes are also employed to shift Siamenoside I distribution to increase yield of Siamenoside I and reduce reaction contaminants. Methods of purifying bioconversion reaction product are also described. Siamenoside I obtained using these methods is a useful sweetener and flavor enhancer for food and beverage compositions and the like.

Abstract: An indication of an instantiation of a first graphical user interface item representing a first data pool component being specified to be included in a data pool is received. An indication of an instantiation of a second graphical user interface item representing a second data pool component being specified to be included in the data pool is received. The second graphical user interface item is graphically instantiated as connected with the first graphical user interface item to indicate that the first data pool component and the second data pool component belong to the same data pool able to be referenced as a combined single data entity. An indication of an instantiation of a third graphical user interface item representing a data management action to be applied to the data pool, wherein the third graphical user interface item is graphically instantiated as connected with a graphical representation of the data pool is received.

Abstract: A specification of a data protection intent is received. Configurations for a plurality of different data management services are automatically determined in an attempt to achieve the specified data protection intent. The determined configurations in the plurality of different data management services are automatically implemented.

Abstract: The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation. The method allows the introduction of genetic edits into the genome of a microbial host cell in an iterative fashion that does not require the use of functional counterselection following at least one round of transformation. It can be used to rapidly stack genetic edits in the genome of a microbial host cell. Kits for performing the methods are also disclosed.

Abstract: Method and apparatus for creating a fluid communication line in a downhole environment between an annular chamber and a throughbore of a tool. The tubular wall therebetween is provided with circumferentially arranged recesses extending into the wall to provide selected thin-walled sections for perforation by a communication tool. The communication tool has two oppositely arranged punch heads, one aligned with a recess and the other between neighbouring recesses giving an orientationless configuration in operation. An embodiment for creating a fluid communication line through a tubing retrievable safety valve for operation of a wireline retrievable safety valve located therein is described.

Abstract: A hot-rolled or cold-rolled steel plate having a composition including, in weight percent: 0.6%?C?0.9%; 17%?Mn?22%; 0.2%?Al?0.9%; 0.2%?Si?1.1%; with 0.85%?Al+Si?1.6%; 1.2%?Cu?1.7%; S?0.030%; P?0.080%; N?0.1%; 0<Nb?0.25%; 0<V?0.5%; 0<Ti?0.5%; 0<Ni?2%; trace amounts ?Cr?2% and B?0.010% is provided. A remainder of the composition includes iron and impurities resulting from production of the steel plate. A method for manufacturing a steel plate and use of the steel plate in the automotive industry is also provided.

Abstract: The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation. The method allows the introduction of genetic edits into the genome of a microbial host cell in an iterative fashion that does not require the use of functional counterselection following at least one round of transformation. It can be used to rapidly stack genetic edits in the genome of a microbial host cell. Kits for performing the methods are also disclosed.