Patents by Inventor Cornelia Hertel

Cornelia Hertel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW BIARYL AMIDE DERIVATIVES
    Publication number: 20150065516
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 29, 2014
    Publication date: March 5, 2015
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Halyan Wang
  • Biaryl amide derivatives
    Patent number: 8912221
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 16, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • Glucocorticoid receptor antagonists
    Patent number: 8883786
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • Aryl-benzocycloalkyl amide derivatives
    Patent number: 8592426
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: November 26, 2013
    Assignee: Hoffmann—La Roche Inc.
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20130045972
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Application
    Filed: February 13, 2012
    Publication date: February 21, 2013
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES
    Publication number: 20130018055
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 17, 2012
    Publication date: January 17, 2013
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • NEW BIARYL AMIDE DERIVATIVES
    Publication number: 20120165338
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 19, 2011
    Publication date: June 28, 2012
    Inventors: Johannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
  • Glucocorticoid receptor antagonists
    Patent number: 8143280
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: March 27, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • Naphthaline derivatives as H3 inverse agonists
    Patent number: 7608617
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 27, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Jean-Marc Plancher, Susanne Raab, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler
  • Quinoline derivatives as H3R inverse agonists
    Patent number: 7534891
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: May 19, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Susanne Raab, Hans Richter, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler
  • GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20090088425
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Application
    Filed: September 15, 2008
    Publication date: April 2, 2009
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • Indole derivatives as H3 inverse agonists
    Patent number: 7361682
    Abstract: The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: April 22, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Susanne Raab, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler, Jean-Marc Plancher
  • Naphthaline derivatives as H3 inverse agonists
    Publication number: 20070265254
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 15, 2007
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Jean-Marc Plancher, Susanne Raab, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler
  • Naphthaline derivatives as H3 inverse agonists
    Patent number: 7259158
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Jean-Marc Plancher, Susanne Raab, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler
  • Fluorescently labeled growth hormone secretagogue
    Patent number: 7186798
    Abstract: The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: March 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thilo Enderle, Martin Graf, Cornelia Hertel, Sannah Jensen Zoffmann, Eric Argirios Kitas
  • Fluorescently labeled growth hormone secretagogue
    Patent number: 7173109
    Abstract: The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thilo Enderle, Martin Graf, Cornelia Hertel, Sannah Jensen Zoffmann, Eric Argirios Kitas
  • Tritiated growth hormone secretagogue mk-0677
    Publication number: 20060204436
    Abstract: The present invention relates to a tritiated growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, or of compounds having activity as growth hormone secretagogues.
    Type: Application
    Filed: June 18, 2004
    Publication date: September 14, 2006
    Inventors: Cornelia Hertel, Philipp Huguenin, Sannah Jensen Zoffmann, Jean-Marc Plancher
  • Quinoline derivatives as H3R inverse agonists
    Publication number: 20060084679
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: October 14, 2005
    Publication date: April 20, 2006
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Susanne Raab, Hans Richter, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler
  • Fluorescently labeled growth hormone secretagogue
    Publication number: 20060073522
    Abstract: The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening.
    Type: Application
    Filed: December 12, 2005
    Publication date: April 6, 2006
    Inventors: Thilo Enderle, Martin Graf, Cornelia Hertel, Sannah Zoffmann, Eric Kitas
  • Naphthaline derivatives as H3 inverse agonists
    Publication number: 20060009449
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 1, 2005
    Publication date: January 12, 2006
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Jean-Marc Plancher, Sussanne Raab, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler