Abstract: A spray device has a spray nozzle unit (1), wherein said spray nozzle unit (1) comprises a cavity (5) with an inlet (2) for receiving a pressurized liquid at an operating pressure and an outlet (3) for releasing a liquid spray during operation. A spray nozzle body (10) is fitted sealingly within said cavity (5), having a perforated nozzle layer (14) with at least one spray orifice (16) that extends between an upstream surface and a down stream surface thereof releasing at least one jet of said liquid spray at said downstream surface of said nozzle layer. The spray nozzle unit (1) is provided with a pressure safety device (30) upstream of said spray nozzle body (10). Said pressure safety device (30) comprises a closed burst layer (34) that closes a fluid pathway between said inlet (2) and said spray nozzle body (10) but ruptures once a threshold pressure is exceeded. Said operating pressure exceeds said threshold pressure.

Abstract: The present invention relates to a spray of microjets emanating at an inclined angle from nozzles comprised in a substantially planar membrane layer. A spray nozzle unit for spraying a plurality of fluidic microjets from a pressurized liquid comprises a substantially planar (semiconductor) support having an upstream surface and a downstream surface, and a spray membrane layer arranged on the downstream surface of the support. The spray membrane layer comprises a plurality of nozzle orifices each configured for spraying a fluidic microjet in a Rayleigh regime. Thee support defines a cavity extending from the upstream surface to the spray membrane layer. The cavity is in fluid communication with each one of the nozzle orifices for supplying the pressurized liquid to the nozzle orifices. A position of the nozzle orifices, seen along a direction perpendicular to the downstream surface, is offset in respect of a centre of the cavity.

Abstract: A spray device for delivering a liquid spray, having a spray length, through air to a target, in particular an eye, comprises a container for holding a liquid, means for pressurizing a quantity of said liquid to an elevated operating pressure, and comprises a nozzle member that comprises a nozzle plate with a plurality of nozzle orifices of substantially identical size, extending through said nozzle plate and communicating with said means to receive a quantity of pressurized liquid at said operating pressure. Said nozzle orifices discharge said liquid spray at an outlet surface of said nozzle member member over said spray length Their substantially identical size is between lower and upper limits (Dmin), (Dmax), wherein said lower limit is approximately: D ? min ? 1 / 10 ? L ? ? ? ? P / ? , wherein said upper limit is approximately: D max ? 1 / 10 ? 2 ? L ? ? ? ? P / ? . ??18 ?/?, ?=1,8.

Abstract: An atomizer device comprises a container (20) with a liquid chamber (21) for receiving a liquid for atomizing and a spray nozzle (50) which is able and configured to form a mist from the liquid under an increased operating pressure. The liquid chamber (21) is closed by a plunger (22) which is received movably therein and is able and configured to expel during an axial displacement at least a part of the liquid from the liquid chamber. Provided between the plunger (22) and the spray nozzle (50) is an air bubble barrier (80) which is at least substantially unbridgeable to possible air bubbles in the liquid, but which comprises a passage (85) for the purpose of allowing at least substantially free passage of the liquid. In a method for preparing such a container it is subjected to a centrifuging step in order to expel possibly enclosed air upstream of the barrier device as far as possible.

Abstract: An atomizer device for atomizing a liquid under increased pressure, comprising an atomizer body 14 with one or more atomizing openings from which a mist formed from the liquid escapes during operation. The device comprises a valve device 20, 30 upstream of the atomizer body. The valve device 20, 30 comprises a valve cavity 31 with a valve body 32 and a spring chamber 21 in which spring means 22 are compressible counter to a spring tension. The valve body 24 receives the liquid in valve cavity 31 with a first operative cross-section D1, which first operative cross-section is smaller than a second operative cross-section D2 of spring chamber 21 in which spring means 22 are compressible.

Abstract: A spray device has a spray nozzle unit (1), wherein said spray nozzle unit (1) comprises a cavity (5) with an inlet (2) for receiving a pressurized liquid at an operating pressure and an outlet (3) for releasing a liquid spray during operation. A spray nozzle body (10) is fitted sealingly within said cavity (5), having a perforated nozzle layer (14) with at least one spray orifice (16) that extends between an upstream surface and a down stream surface thereof releasing at least one jet of said liquid spray at said downstream surface of said nozzle layer. The spray nozzle unit (1) is provided with a pressure safety device (30) upstream of said spray nozzle body (10). Said pressure safety device (30) comprises a closed burst layer (34) that closes a fluid pathway between said inlet (2) and said spray nozzle body (10) but ruptures once a threshold pressure is exceeded. Said operating pressure exceeds said threshold pressure.

Abstract: The present invention provides a spray device that generates a fluidic micro-jet spray and that allows and retains a relatively narrow droplet size distribution, of micro-jets and droplets obtained via the Rayleigh breakup mechanism, under a well-defined control of coalescence. To that end a spray device is characterized in that a spray nozzle unit is formed by a nozzle body (1), comprising a support body (2) with at least one cavity (3) spanned by a membrane layer (4) having a nozzle orifice throughout a thickness of said membrane layer at an area of said cavity (3) in fluid communication with that cavity (3). The nozzle orifice may be part of a first relatively dense group of first orifices (5a) or of a less dense second group of second nozzle orifices (5b) in the membrane layer. A mean diameter of the nozzle orifices (5a) located in the first group substantially differs from the mean diameter of the nozzle orifices (5b) in the second group to obtain a uniform droplet size distribution in the spray.

Abstract: The present invention relates to a spray device, comprising a spray nozzle body (2) and a substantially planar membrane layer (6) suspended over a nozzle cavity (3) to generate microjets, especially for pharmaceutical applications, in particular preservative free formulations. The nozzle body (2,8) contains a microbial barrier, particularly a microvalve (23,24) between a fluid supply channel (9) and said cavity (3).

Abstract: The present invention relates to a spray device, comprising a spray nozzle body (2) and a substantially planar membrane layer (6) suspended over a nozzle cavity (3) to generate microjets, especially for pharmaceutical applications, in particular preservative free formulations. The nozzle body (2,8) contains a microbial barrier, particularly a microvalve (23,24) between a fluid supply channel (9) and said cavity (3).

Abstract: The invention relates to a spray device having a spray nozzle unit and at least one further spray nozzle unit. Each spray nozzle unit has at least one spray nozzle body, wherein said at least one spray nozzle body comprises a chamber for receiving a pressurized fluid. Said chamber is bounded by a spray wall having at least one spray orifice that extends through said spray wall and opens to an external environment. Each of said at least one orifice in a spray wall has a substantially identical predetermined size lying in a predetermined range and releases a mono disperse spray jet of the pressurized fluid fed from the associated reservoir. Said range within said first spray nozzle unit differs from said range within said at least one further spray nozzle unit, particularly said ranges do not overlap.

Abstract: A method for manufacturing an spray device includes assembling at least one spray nozzle plate into a thermoplastic holder, while controlling the temperature of the spray nozzle plate and/or the holder and as a result at least locally plastically deforming the holder permanently. After the thermoplastic deformation of a seat of the holder, a diameter of the seat of the holder upstream of the spray nozzle plate exceeds a diameter of the seat of the holder downstream of the nozzle plate. The thermoplastic holder may have a tapered seat, where the smallest cross section of the tapered seat is smaller than the spray nozzle plate, where a widest side of the tapered seat is pointing towards a supply side of the liquid.

Abstract: A method for manufacturing an spray device includes assembling at least one spray nozzle plate into a thermoplastic holder, while controlling the temperature of the spray nozzle plate and/or the holder and as a result at least locally plastically deforming the holder permanently. After the thermoplastic deformation of a seat of the holder, a diameter of the seat of the holder upstream of the spray nozzle plate exceeds a diameter of the seat of the holder downstream of the nozzle plate. The thermoplastic holder may have a tapered seat, where the smallest cross section of the tapered seat is smaller than the spray nozzle plate, where a widest side of the tapered seat is pointing towards a supply side of the liquid.

Abstract: The invention relates to a device for the microfiltration, ultrafiltration, or nanofiltration and/or the emulsification of liquids. The device has at least one rotatable membrane medium, which has a filtrate/permeate side or a side facing a dispersed phase and a concentrate/retentate side or a side facing a coherent phase and which can be rotated in a container in order to produce a vacuum on an unfiltered liquid side or the side facing the coherent phase on partial regions of the at least one rotatable membrane medium in the container in small time segments at a frequency of 1-100 Hz. Said container has at least one feed for an unfiltered liquid or the coherent phase, at least one overflow for an unfiltered liquid or an emulsion, and at least one rotatable channel for filtrate/permeate drainage or feed of the dispersed phase, and a suction device, in particular in the manner of a suction strip or nozzle plate.

Abstract: The present invention relates to a spray device, comprising a spray nozzle body (2) and a substantially planar membrane layer (6) suspended over a nozzle cavity (3) to generate microjets, especially for pharmaceutical applications, in particular preservative free formulations. The nozzle body (2,8) contains a microbial barrier, particularly a microvalve (23,24) between a fluid supply channel (9) and said cavity (3).

Abstract: The present invention relates to a spray of microjets emanating at an inclined angle from nozzles comprised in a substantially planar membrane layer. A spray nozzle unit for spraying a plurality of fluidic microjets from a pressurized liquid comprises a substantially planar (semiconductor) support having an upstream surface and a downstream surface, and a spray membrane layer arranged on the downstream surface of the support. The spray membrane layer comprises a plurality of nozzle orifices each configured for spraying a fluidic microjet in a Rayleigh regime. Thee support defines a cavity extending from the upstream surface to the spray membrane layer. The cavity is in fluid communication with each one of the nozzle orifices for supplying the pressurized liquid to the nozzle orifices. A position of the nozzle orifices, seen along a direction perpendicular to the downstream surface, is offset in respect of a centre of the cavity.

Abstract: A system for packaging a low acid liquid is provided herein. The system includes feeding unit configured to feed the low acid liquid into a filtration unit. The filtration unit is configured to filter the low acid liquid by using a number of pores provided on a micro sieve membrane. Further, the filtered low acid liquid is provided to an aseptic buffer unit configured to fill the aseptic filtered low acid liquid into packaging containers. The system further includes an automatic cleaning in place unit configured to automatically clean the feeding unit, the filtration unit and the aseptic buffer unit by decontamination using a decontaminating material.

Abstract: A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.

Abstract: A method for manufacturing an spray device includes assembling at least one spray nozzle plate into a thermoplastic holder, while controlling the temperature of the spray nozzle plate and/or the holder and as a result at least locally plastically deforming the holder permanently. After the thermoplastic deformation of a seat of the holder, a diameter of the seat of the holder upstream of the spray nozzle plate exceeds a diameter of the seat of the holder downstream of the nozzle plate. The thermoplastic holder may have a tapered seat, where the smallest cross section of the tapered seat is smaller than the spray nozzle plate, where a widest side of the tapered seat is pointing towards a supply side of the liquid.

Abstract: A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.

Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.