Patents by Inventor Cornelis Johannes Maria Van Rijn
Cornelis Johannes Maria Van Rijn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9638636Abstract: A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.Type: GrantFiled: May 29, 2013Date of Patent: May 2, 2017Assignee: VyCAP B.V.Inventors: Arjan Gerhardus Johannes Tibbe, Cornelis Johannes Maria van Rijn, Leonardus Wendelinus Mathias Marie Terstappen
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Patent number: 9545471Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.Type: GrantFiled: August 6, 2014Date of Patent: January 17, 2017Assignee: VIATAR LLCInventors: Cornelis Johannes Maria van Rijn, Ilan K. Reich
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Publication number: 20160201273Abstract: The present invention relates to an artificial turf comprising fibers having advantageous properties such as a tuned hydrophilicity and the ability to transport water, enabling self-cooling through water evaporation. For this the artificial turf comprises at least one fiber having a core and a shell, characterized in that an outer surface of the shell has a contact angle with water of less than 90°, and that the shell comprises at least one axially oriented groove with a width of less than 500 micrometers.Type: ApplicationFiled: June 19, 2014Publication date: July 14, 2016Applicant: Micronext B.V.Inventor: Cornelis Johannes Maria van Rijn
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Publication number: 20160185474Abstract: A system for packaging a low acid liquid is provided herein. The system includes feeding unit configured to feed the low acid liquid into a filtration unit. The filtration unit is configured to filter the low acid liquid by using a number of pores provided on a micro sieve membrane. Further, the filtered low acid liquid is provided to an aseptic buffer unit configured to fill the aseptic filtered low acid liquid into packaging containers. The system further includes an automatic cleaning in place unit configured to automatically clean the feeding unit, the filtration unit and the aseptic buffer unit by decontamination using a decontaminating material.Type: ApplicationFiled: July 27, 2015Publication date: June 30, 2016Inventors: Laurent Robert BRONNER, Antje SPORS, Franz LIEBERMANN, Cornelis Johannes Maria VAN RIJN
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Publication number: 20160045871Abstract: The invention relates to a device for the microfiltration, ultrafiltration, or nanofiltration and/or the emulsification of liquids. The device has at least one rotatable membrane medium, which has a filtrate/permeate side or a side facing a dispersed phase and a concentrate/retentate side or a side facing a coherent phase and which can be rotated in a container in order to produce a vacuum on an unfiltered liquid side or the side facing the coherent phase on partial regions of the at least one rotatable membrane medium in the container in small time segments at a frequency of 1-100 Hz. Said container has at least one feed for an unfiltered liquid or the coherent phase, at least one overflow for an unfiltered liquid or an emulsion, and at least one rotatable channel for filtrate/permeate drainage or feed of the dispersed phase, and a suction device, in particular in the manner of a suction strip or nozzle plate.Type: ApplicationFiled: March 26, 2014Publication date: February 18, 2016Inventors: Franz LIEBERMANN, Cornelis Johannes Maria VAN RIJN
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Publication number: 20150190757Abstract: A filtration module is disclosed, comprising at least one hollow capillary filtration membrane, in particular having a retentate side inside the hollow capillary and a permeate side outside the capillary, characterized in that the retentate side of the capillary filtration membrane has at least one dent with an aperture angle ? smaller than 180°. A method to apply a filtration module according to the invention is disclosed characterized in that release of a cake layer formed at the retention side of the membrane is enforced, as well as further disrupture and disintegration of the cake layer, by applying a backwash cycle with a reverse flow at a backwash pressure lower than the maximum trans membrane pressure during a forward filtration step of a process liquid.Type: ApplicationFiled: July 15, 2013Publication date: July 9, 2015Applicant: MICRONEXT B.V.Inventors: Cornelis Johannes Maria van Rijn, Paulus Hendricus Johannes Nederkoorn
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Publication number: 20150160135Abstract: A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.Type: ApplicationFiled: May 5, 2013Publication date: June 11, 2015Applicant: VyCAP B.V.Inventors: Arjan Gerhardus Johannes Tibbe, Cornelis Johannes Maria van Rijn, Leonardus Wendelinus Mathias Marie Terstappen
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Publication number: 20150093486Abstract: Nozzle device and nozzle for atomisation and/or filtration as well as methods for using the same. The present invention relates to a nozzle and nozzle device for atomisation, in particular a micro-machined reinforced nozzle plate, that may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and to make small air bubbles into a liquid (foam) and to methods of making the same. The invention is further related to a nozzle part for filtration as well as means and methods to facilitate atomisation and filtration.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Applicant: AQUAMARIJN HOLDING B.V.Inventors: Cornelis Johannes Maria van Rijn, Wietze Nijdam
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Publication number: 20150041398Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.Type: ApplicationFiled: August 6, 2014Publication date: February 12, 2015Inventors: Cornelis Johannes Maria van RIJN, Ilan K. REICH
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Patent number: 8936160Abstract: Nozzle device and nozzle for atomisation and/or filtration as well as methods for using the same. The present invention relates to a nozzle and nozzle device for atomisation, in particular a micro-machined reinforced nozzle plate, that may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and to make small air bubbles into a liquid (foam) and to methods of making the same. The invention is further related to a nozzle part for filtration as well as means and methods to facilitate atomisation and filtration.Type: GrantFiled: April 16, 2012Date of Patent: January 20, 2015Assignee: Aquamarijn Holding B.V.Inventors: Cornelis Johannes Maria Van Rijn, Jeroen Mathijn Wissink, Wietze Nijdam
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Patent number: 8814059Abstract: An atomizing device, includes an atomizing body (1) with an inlet (16) for receiving a fluid under increased pressure, and with at least one set of outflow ports (18) for allowing the fluid to escape on a delivery side with forming of a vapor. Imaginary central axes of the outflow ports directed in a flow direction herein enclose a mutual angle (?) in order to intersect each other at an intersection (S). The atomizing body includes a roof (21) and a bottom (11 which extend over at least a first distance (d1) beyond the set of outflow ports (18) and bound a vaporizing space (17) on either side. The intersection (S) of the imaginary central axes of the outflow ports lies at a second distance (d2) from the set of outflow ports, wherein the second distance (d2) is greater than the first distance (d1) and extends beyond the vaporizing space.Type: GrantFiled: June 30, 2008Date of Patent: August 26, 2014Assignee: Medspray XMEMS B.V.Inventors: Jeroen Mathijn Wissink, Iwan Rutger Heskamp, Wilhelmus Petrus Johannes De Kruijf, Wietze Nijdam, Cornelis Johannes Maria Van Rijn
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Publication number: 20140190888Abstract: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a number of openings (preferably precise) which yield minimal detrimental effect both quantitatively and qualitatively on cells present in the bodily fluid during the separation process. For example, in some embodiments, a majority percentage of circulating tumor cells are captured by a filter while a majority percentage of leukocytes, for example, are allowed to pass, where the passed leukocytes retain their vitality.Type: ApplicationFiled: January 24, 2014Publication date: July 10, 2014Applicant: VIATAR LLCInventors: Cornelis Johannes Maria van RIJN, Jacob BAGGERMAN, Ilan REICH
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Publication number: 20120228238Abstract: Nozzle device and nozzle for atomisation and/or filtration as well as methods for using the same. The present invention relates to a nozzle and nozzle device for atomisation, in particular a micro-machined reinforced nozzle plate, that may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and to make small air bubbles into a liquid (foam) and to methods of making the same. The invention is further related to a nozzle part for filtration as well as means and methods to facilitate atomisation and filtration.Type: ApplicationFiled: April 16, 2012Publication date: September 13, 2012Applicant: MEDSPRAY XMEMS B.V.Inventors: Cornelis Johannes Maria VAN RIJN, Jeroen Mathijn Wissink, Wietze Nijdam
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Patent number: 8100348Abstract: A device for generating microspheres from a fluid includes an injection plate with at least one defined injection channel having on an inlet side an inflow opening for receiving the fluid and on an outlet side an outflow opening for delivering microspheres formed from the fluid. The device includes feed elements for carrying fluid through the injection channel and is in open communication, on a side wall thereof, with at least one secondary channel at least at the position of a break-up point where at least during operation a flow of fluid in the injection channel breaks up into separate parts. The secondary channel includes in use an auxiliary fluid at least at the position of a break-up point.Type: GrantFiled: May 25, 2005Date of Patent: January 24, 2012Assignee: Nanomi B.V.Inventors: Jeroen Wissink, Cornelis Johannes Maria Van Rijn, Wietze Nijdam, Christiaan Haldir Goeting, Iwan Rutger Heskamp, Gerrit Jan Veldhuis
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Publication number: 20110244443Abstract: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a number of openings (preferably precise) which yield minimal detrimental effect both quantitatively and qualitatively on cells present in the bodily fluid during the separation process. For example, in some embodiments, a majority percentage of circulating tumor cells are captured by a filter while a majority percentage of leukocytes, for example, are allowed to pass, where the passed leukocytes retain their vitality.Type: ApplicationFiled: March 31, 2011Publication date: October 6, 2011Applicant: Viatar LLCInventors: Cornelis Johannes Maria van Rijn, Jacob Baggerman, Ilan Reich
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Patent number: 7963466Abstract: Nozzle device and nozzle for atomization and/or filtration as well as methods for using the same. The nozzle and nozzle device for atomization, in particular a micro-machined reinforced nozzle plate, may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and make small air bubbles into a liquid (foam). A nozzle part for filtration as well as elements and methods to facilitate atomization and filtration are also disclosed.Type: GrantFiled: April 8, 2005Date of Patent: June 21, 2011Assignee: Medspray XEMEMS B.V.Inventors: Cornelis Johannes Maria Van Rijn, Jeroen Mathijn Wissink, Wietze Nijdam
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Publication number: 20110049262Abstract: An atomizing device, includes an atomizing body (1) with an inlet (16) for receiving a fluid under increased pressure, and with at least one set of outflow ports (18) for allowing the fluid to escape on a delivery side with forming of a vapour. Imaginary central axes of the outflow ports directed in a flow direction herein enclose a mutual angle (?) in order to intersect each other at an intersection (S). The atomizing body includes a roof (21) and a bottom (11 which extend over at least a first distance (d1) beyond the set of outflow ports (18) and bound a vaporizing space (17) on either side. The intersection (S) of the imaginary central axes of the outflow ports lies at a second distance (d2) from the set of outflow ports, wherein the second distance (d2) is greater than the first distance (d1) and extends beyond the vaporizing space.Type: ApplicationFiled: June 30, 2008Publication date: March 3, 2011Applicant: MEDSPRAY XMEMS B.V.Inventors: Jeroen Mathijn Wissink, Iwan Rutger Heskamp, Wilhelmus Petrus Johannes De Kruijf, Wietze Nijdam, Cornelis Johannes Maria Van Rijn
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Patent number: 7531120Abstract: Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.Type: GrantFiled: December 3, 2001Date of Patent: May 12, 2009Assignee: Aquamarijn Holding B.V.Inventors: Cornelis Johannes Maria Van Rijn, Laura Vogelaar, Wietze Nijdam, Jonathan Nathaniel Barsema, Matthias Wessling
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Publication number: 20080217262Abstract: Nozzle device and nozzle for atomization and/or filtration as well as methods for using the same. The nozzle and nozzle device for atomization, in particular a micro-machined reinforced nozzle plate, may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and make small air bubbles into a liquid (foam). A nozzle part for filtration as well as elements and methods to facilitate atomization and filtration are also disclosed.Type: ApplicationFiled: March 5, 2008Publication date: September 11, 2008Applicant: AQUAMARIJN HOLDING B.V.Inventor: Cornelis Johannes Maria Van Rijn
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Publication number: 20040028875Abstract: Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.Type: ApplicationFiled: September 29, 2003Publication date: February 12, 2004Inventors: Cornelis Johannes Maria Van Rijn, Laura Vogelaar, Wietze Nijdam, Jonathan Nathaniel Barsema, Matthias Wessling