Abstract: Provided herein is A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

Abstract: Embodiments described herein provide for a non-transitory machine-readable medium storing instructions to cause one or more processors to select a set of content items from a content item collection based upon a temporal relevance and a contextual relevance to a period of time, rank the set of content items based on at least one of a content item category or a content item predefined relevance score, partition the period of time into a set of time slots to schedule for rendering content in an application, rank the set of time slots based on device usage analysis for the period of time, and schedule the set of content items into the set of time slots in accordance with the rankings.

Abstract: Techniques are disclosed for advantageously forecasting an inventory of a product having a particular duration (e.g., video content). The technique can include determining the particular configuration (e.g., maximum number of impressions, maximum amount of time permitted) of breaks identified within an impression log. Based on the number of breaks and the configurations of the breaks, the technique can forecast a future inventory of the product. In some implementations, the disclosed technique can identify an amount of a previous break that was not filled with video content. These forecasts can enable product sellers to better communicate with their customers, negotiate supply contracts, price their products, plan for business operations, etc.

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

Abstract: A pluggable module for use in a networking system includes a body with an electrical interface configured to be inserted into networking equipment; a head connected to the body and including a handle; and a light pipe with an entry in or near the body, the light pipe configured to provide light from inside the body to the handle. The body can include a light source directed towards the entry. The light source can be a Light Emitting Diode (LED). Advantageously, this disclosure provides an ability to support status lights in a very small surface area on a pluggable module.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: This invention relates to electrosurgical systems for coagulation and ablation of tissue, including in relation to tissue biopsy.

Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.

Abstract: Protection elements are provided for protecting optical networking systems during shipment. In one implementation, a system includes a card having one or more sockets, each socket having a connector device. The system also includes a pluggable module having an interface configured to connect with the connector device of a respective socket when the pluggable module is fully seated in the socket. A first protection element is configured to be held in place near a front edge of the socket. The first protection element is configured to allow the pluggable module to be arranged in a partially inserted position within the socket. Also, the first protection element is further configured to block the pluggable module from being fully seated in the socket to thereby prevent the interface of the pluggable module from contacting the connector device of the socket.

Abstract: Systems, devices, and methods are disclosed for characterizing joint attention. A method includes dynamically obtaining video streams of participants; dynamically obtaining gaze streams; dynamically providing a cue to the participants to view the object; dynamically detecting a joint gaze based on the gaze streams focusing on the object over a time interval; and dynamically providing feedback based on detecting the joint gaze.

Abstract: Vertical transmission line probes having alternating capacitive and inductive sections are provided. These alternating sections can be designed to provide a desired transmission line impedance (e.g., between 10 and 100 Ohms, preferably 50 Ohms). Probe flexure in operation is mainly in the inductive sections, advantageously reducing flexure stresses on the dielectrics in the capacitive sections.

Abstract: Improved electrically conductive guide plates for vertical probe arrays are provided by patterning a thin metal layer disposed on an insulating substrate. Holes passing through the guide plate for guiding probes can be electrically connected or isolated from each other in any pattern according to the deposition of the metal. Such structures can include several distinct ground and/or voltage planes. Furthermore, passive electrical components can be included in the guide plate, by patterning of the deposited metal and/or by integration of passive electrical components with the deposited metal traces.

Abstract: Vertical probe arrays having angled guide plates are provided. With this configuration, the probes can be straight conductors (when mechanically undeformed) and the mechanical bias provided by the angled guide plates can ensure the probes have a well-defined deformation when the probe array make contact to the device under test. This allows the use of straight conductors as probes without suffering from probe shorting and mechanical interference caused by straight probes buckling in unpredictable directions when vertically compressed.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.

Abstract: Protection elements are provided for protecting optical networking systems during shipment. In one implementation, a system includes a card having one or more sockets, each socket having a connector device. The system also includes a pluggable module having an interface configured to connect with the connector device of a respective socket when the pluggable module is fully seated in the socket. A first protection element is configured to be held in place near a front edge of the socket. The first protection element is configured to allow the pluggable module to be arranged in a partially inserted position within the socket. Also, the first protection element is further configured to block the pluggable module from being fully seated in the socket to thereby prevent the interface of the pluggable module from contacting the connector device of the socket.

Abstract: Power supply systems are provided for carrying electrical power from a power source to a circuit board mounted on a housing, shelf, cabinet, etc. for supporting networking equipment. A busbar assembly, according to one embodiment, includes a pair of conductive strips configured to carry electrical power. The pair of conductive strips are arranged on a front-facing surface of a non-conductive vertical substrate. The busbar assembly further includes one or more alignment blocks configured to hold the pair of conductive strips in a fixed position with respect to the non-conductive vertical substrate. Each of the one or more alignment blocks is configured to guide a pair of power connectors of a circuit board for making electrical contact with the pair of conductive strips, while allowing simultaneous mating of signal connectors on the circuit board with signal connectors on the substrate, when the circuit board is being installed in a housing.

Abstract: Power supply systems are provided for carrying electrical power from a power source to a circuit board mounted on a housing, shelf, cabinet, etc. for supporting networking equipment. A busbar assembly, according to one embodiment, includes a pair of conductive strips configured to carry electrical power. The pair of conductive strips are arranged on a front-facing surface of a non-conductive vertical substrate. The busbar assembly further includes one or more alignment blocks configured to hold the pair of conductive strips in a fixed position with respect to the non-conductive vertical substrate. Each of the one or more alignment blocks is configured to guide a pair of power connectors of a circuit board for making electrical contact with the pair of conductive strips, while allowing simultaneous mating of signal connectors on the circuit board with signal connectors on the substrate, when the circuit board is being installed in a housing.

Abstract: A system and method for applying energy, particularly radiofrequency (RF) electrical energy, to a living body can be used in tissue ablation.

Abstract: Disclosed herein are systems and methods for assessing cognitive function. In an example embodiment, an assessment computer receives demographics data relating to an individual and provides a cognitive assessment test to a portable touchscreen personal computing device, for self administration of the test by the individual. The portable touchscreen personal computing device generates cognitive assessment stimuli, receives responses to the stimuli from the individual via touchscreen activations, measures reaction times of the responses, and transmits the responses and reaction times to the assessment computer for storage in a database. The assessment computer receives cognitive assessment performance data relating to the individual, including the received responses and measured reaction times, and generates performance metrics including at least a cognitive baseline for the individual based at least on the first cognitive assessment performance data.