Patents by Inventor Craig Alan COBURN

Craig Alan COBURN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Publication number: 20230295119
    Abstract: Compounds having the structure of Formula (I) or pharmaceutically acceptable isomers, racemates, hydrates, solvates or salts thereof, where A, R1, R2a, R2b, R2c and R3 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFN? by acting on TYK2 to cause signal transduction inhibition, as well as to pharmaceutical compositions containing the same and to methods of their use and preparation.
    Type: Application
    Filed: April 14, 2021
    Publication date: September 21, 2023
    Inventors: Craig Alan Coburn, Chad Alan Van Huis, Thomas Daniel Aicher
  • Small molecule drug conjugates of gemcitabine monophosphate
    Patent number: 11760773
    Abstract: Disclosed are compounds having formula (1): or a pharmaceutically acceptable salt, ester, amide, solvate, or stereoisomer thereof, wherein L, Y1, Y2, Y3, Y4, Y5, Z1, Z2, Z3, Z4, Z5, Z6 are each as defined in the specification; compositions thereof; uses thereof; and methods of use thereof.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: September 19, 2023
    Assignee: MaveriX Oncology, Inc.
    Inventors: Steven Albert Everett, Craig Alan Coburn
  • KINASE INHIBITORS
    Publication number: 20230219923
    Abstract: Disclosed herein are 1H-indole-7-carboxamide derivatives as protein kinase inhibitors, in particular Bruton's tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for preparing them and uses of such protein kinase inhibitors to treat or prevent diseases, disorders and conditions associated with kinase function. In particular, the present invention relates to selective BTK inhibitors.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 13, 2023
    Inventors: Craig Alan Coburn, Dange Vijay Kumar, Daniel John Buzard, Nidhi Arora
  • AMINO-PYRAZINECARBOXAMIDE COMPOUNDS, CONJUGATES, AND USES THEREOF
    Publication number: 20220362396
    Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: November 24, 2020
    Publication date: November 17, 2022
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • ANTIBODY CONJUGATES OF TOLL-LIKE RECEPTOR AGONISTS
    Publication number: 20220323596
    Abstract: Imidazoquinoline compounds of formula (IA), conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed imidazoquinoline compounds are useful, among other things, in the treating of cancer and modulating TLR7. Additionally, imidazoquinoline compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: September 12, 2019
    Publication date: October 13, 2022
    Inventors: Sean Wesley SMITH, Craig Alan COBURN
  • CYCLIC AMINO-PYRAZINECARBOXAMIDE COMPOUNDS AND USES THEREOF
    Publication number: 20220169660
    Abstract: Cyclic amino-pyrazinecarboxamide compounds, salts, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of disease, for example cancer and/or fibrotic diseases, and modulating TGF?R2.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 2, 2022
    Inventors: Sean Wesley SMITH, Craig Alan COBURN
  • SUBSTITUTED BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF
    Publication number: 20220048895
    Abstract: Benzazepine compounds and salts thereof, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds and salts thereof are useful, among other things, in treating of cancer and activating an immune response. Additionally, benzazepine compounds or salts thereof attached to an antibody construct to form an antibody conjugate are described herein.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Inventors: Craig Alan COBURN, Sean Wesley SMITH
  • KINASE INHIBITORS
    Publication number: 20220009920
    Abstract: Disclosed herein are protein kinase inhibitors, in particular Bruton's tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for preparing them and uses of such protein kinase inhibitors to treat or prevent diseases, disorders and conditions associated with kinase function. In particular, the present invention relates to selective BTK inhibitors.
    Type: Application
    Filed: April 8, 2021
    Publication date: January 13, 2022
    Inventors: Craig Alan Coburn, Dange Vijay Kumar, Luis Antonio Lopez, Daniel John Buzard
  • NOVEL SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE DERIVATIVES
    Publication number: 20210380626
    Abstract: Disclosed are compounds having formula (I): or a pharmaceutically acceptable salt, ester, amide, solvate, or stereoisomer thereof, wherein L, Y1, Y2, Y3, Y4, Y5, Z1, Z2, Z3, Z4, Z5, Z6, and Effector are each as defined in the specification; compositions thereof; uses thereof; and methods of use thereof.
    Type: Application
    Filed: February 4, 2019
    Publication date: December 9, 2021
    Inventors: Steven Albert EVERETT, Craig Alan COBURN
  • ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF
    Publication number: 20210154188
    Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 27, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Robert Finley Dubose
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210154317
    Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.
    Type: Application
    Filed: June 24, 2020
    Publication date: May 27, 2021
    Inventors: Peter Armstrong Thompson, Valerie Odegard, Robert Finley Dubose, Sean Wesley Smith, Craig Alan Coburn
  • ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF
    Publication number: 20210139477
    Abstract: ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: July 16, 2020
    Publication date: May 13, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • SMALL MOLECULE DRUG CONJUGATES OF GEMCITABINE MONOPHOSPHATE
    Publication number: 20210040136
    Abstract: Disclosed are compounds having formula (I): or a pharmaceutically acceptable salt, ester, amide, solvate, or stereoisomer thereof, wherein L, Y1, Y2, Y3, Y4, Y5, Z1, Z2, Z3, Z4, Z5, Z6 are each as defined in the specification; compositions thereof; uses thereof; and methods of use thereof.
    Type: Application
    Filed: February 4, 2019
    Publication date: February 11, 2021
    Inventors: Steven Albert Everett, Craig Alan Coburn
  • ANTIBODY CONJUGATES OF IMMUNE-MODULATORY COMPOUNDS AND USES THEREOF
    Publication number: 20200199247
    Abstract: Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein. The disclosed conjugates are useful, among other things, in treating fibrotic diseases, autoimmune diseases, or autoinflammatory diseases, such as by modulating TGF?R1, TGF?R2, TNKS, TNIK, or mTOR.
    Type: Application
    Filed: June 7, 2018
    Publication date: June 25, 2020
    Inventors: Peter Armstrong THOMPSON, Badreddin EDRIS, Craig Alan COBURN, Peter Robert BAUM, Valerie ODEGARD
  • Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
    Publication number: 20200113912
    Abstract: Methods and conjugates are disclosed for alleviating toxicity(ies) associated with administration of immune-stimulatory conjugates, and in particular for alleviating toxicity(ies) associated with intravenous administration of such conjugates.
    Type: Application
    Filed: September 11, 2019
    Publication date: April 16, 2020
    Applicant: Silverback Therapeutics, Inc.
    Inventors: Valerie Odegard, Peter Baum, Sean Wesley Smith, Craig Alan Coburn, Peter Armstrong Thompson
  • BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF
    Publication number: 20200031798
    Abstract: Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: August 7, 2019
    Publication date: January 30, 2020
    Inventors: Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
  • Benzazepine compounds, conjugates, and uses thereof
    Patent number: 10519131
    Abstract: Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 31, 2019
    Assignee: SILVERBACK THERAPEUTICS, INC.
    Inventors: Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
  • TUMOR TARGETING CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20190336615
    Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer.
    Type: Application
    Filed: January 26, 2018
    Publication date: November 7, 2019
    Inventors: Peter Armstrong Thompson, Philip Huat Seng Tan, Peter Robert Baum, Robert Finley Dubose, Craig Alan Coburn, Sean Wesley Smith
  • Benzazepine compounds, conjugates, and uses thereof
    Patent number: 10442790
    Abstract: Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 15, 2019
    Assignee: Silverback Therapeutics, Inc.
    Inventors: Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
  • Benzazepine compounds, conjugates, and uses thereof
    Patent number: 10428045
    Abstract: Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 1, 2019
    Assignee: Silverback Therapeutics, Inc.
    Inventors: Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith