Patents by Inventor Craig E. Masse

Craig E. Masse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20260078125
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: May 23, 2025
    Publication date: March 19, 2026
    Inventor: Craig E. MASSE
  • PYRROLO-PYRIDAZINE INHIBITORS OF JAK2
    Publication number: 20260078131
    Abstract: The present disclosure provides pyrrolo-pyridazine compounds and compositions thereof useful for inhibiting JAK2. In some embodiments, the present disclosure provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as defined in classes and subclasses herein, both singly and in combination.
    Type: Application
    Filed: September 5, 2025
    Publication date: March 19, 2026
    Inventors: Craig E. Masse, Jiayi Xu, Phani Ghanakota, Kevin Robert DeMarco, Susanta Haldar, Alice Hooper
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20250326760
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: January 18, 2025
    Publication date: October 23, 2025
    Inventors: Craig E. MASSE, Jeremy Robert GREENWOOD, Sayan MONDAL, Scott D. COWEN, Thomas H. MCLEAN
  • TYK2 INHIBITOR SYNTHESIS AND INTERMEDIATES THEREOF
    Publication number: 20250206743
    Abstract: Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.
    Type: Application
    Filed: March 24, 2023
    Publication date: June 26, 2025
    Inventors: Craig E. MASSE, Avinash S. PHADKE, Jon P. LAWSON, Stuart LEVY, Xiaowei YANG, Guisheng WU, Shufeng FAN
  • TYK2 inhibitors and uses thereof
    Patent number: 12338242
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: June 24, 2025
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Craig E. Masse
  • 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Patent number: 12275717
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: April 15, 2025
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • Substituted pyrazolo[5?,1?:2,3]pyrimido[5,4-b][1,4]oxazines as TYK2 inhibitors
    Patent number: 12221453
    Abstract: The present invention provides compounds of Formula I?: compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: February 11, 2025
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • Forms and compositions of inhibitors of JAK2
    Patent number: 12162881
    Abstract: The present disclosure provides compounds and compositions thereof which are useful as inhibitors of JAK2 and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: November 8, 2022
    Date of Patent: December 10, 2024
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • FORMS AND COMPOSITIONS OF A JAK2 INHIBITOR
    Publication number: 20240368157
    Abstract: The present disclosure provides solid forms of a JAK2 inhibitor, as well as compositions thereof and methods of using and preparing the same.
    Type: Application
    Filed: May 2, 2024
    Publication date: November 7, 2024
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20240254125
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: March 26, 2024
    Publication date: August 1, 2024
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Patent number: 12043632
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: July 23, 2024
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Patent number: 11970494
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Grant
    Filed: November 8, 2022
    Date of Patent: April 30, 2024
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS
    Publication number: 20240116892
    Abstract: The present disclosure provides heterocyclic amide and urea compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: August 7, 2023
    Publication date: April 11, 2024
    Inventors: Craig E. Masse, Kevin Robert DeMarco, Jiayi Xu, Jeremy R. Greenwood, Phani Ghanakota
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230391797
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: December 23, 2022
    Publication date: December 7, 2023
    Inventors: Markus DAHLGREN, Jeremy Robert Greenwood, Geraldine c. Harriman, Joshua Jahmil Kennedy-Smith, Craig E. Masse, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • TYK2 inhibitors and uses thereof
    Patent number: 11834449
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: December 5, 2023
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jeremy Robert Greenwood, Craig E. Masse
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20230265075
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 24, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Patent number: 11691963
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: July 4, 2023
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20230167110
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: November 8, 2022
    Publication date: June 1, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • FORMS AND COMPOSITIONS OF INHIBITORS OF JAK2
    Publication number: 20230146125
    Abstract: The present disclosure provides compounds and compositions thereof which are useful as inhibitors of JAK2 and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 11, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS TYK2 INHIBITORS
    Publication number: 20230110996
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: June 14, 2022
    Publication date: April 13, 2023
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal