Abstract: The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

Abstract: The inventive tape dispenser includes a cover and a base. The cover includes a forward section, a saddle, a rounded back section, and first and second sidewalls extending downwardly from the forward section and saddle. The forward section of the cover includes a first end from which a means for cutting extends. The base includes a semicircular tape holding portion having a first side opposite a second side, a mounting surface and an inner surface. The inner surface of the base includes a means for gripping the dispenser. The base also includes an arm, a land area extending at an angle from the arm and an edge extending an angle from the land area. The edge is disposed substantially parallel to and proximate to the second sidewall of the cover.

Abstract: The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared therefrom.

Abstract: A horizontally mounted shelf assembly includes an elongated support rail, at least one accessory slidaby connected with the support rail, and at least one stretch releasing adhesive strip arranged between the support rail and the wall for securing the shelf assembly to the wall. Each accessory may also be separately mounted on the wall using stretch releasing adhesive strips.

Abstract: A wall mountable wire grid organizer rack assembly includes a support grid structure including a perimeter frame and a plurality of transverse support members connected with the perimeter frame. A plurality of accessories are removably connected with the support members, and at least one stretch removable adhesive strip is arranged between the support grid and the wall for securing the rack to the wall.

Abstract: A wall mountable shelf assembly includes an elongated support rail, at least one accessory slidably connected with the support rail, and at least one stretch releasing adhesive strip arranged between the support rail and the wall for securing the shelf assembly to the wall.

Abstract: A dispenser has a primary cavity having first and second sides and an open end and a closed end, the open end allowing for the insertion and the removal of a pad of notes. The dispenser also includes a base defining the closed end of the dispenser; front and rear portions, each portion having first and second ends and opposing inside and outside surfaces, the front and rear portions disposed on the base such that the second end of each portion is proximate to the base, the front portion comprises a slot extending from the first end to the second end; and a biasing mechanism disposed proximate the rear portion.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy.

Abstract: Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

Abstract: A device for mounting an item on a surface includes a base plate having front and rear major surfaces, a fastener for securing the base plate to the surface, and a retaining member removably connected with the base plate front major surface to retain the item on the device.

Abstract: A system for automatically creating and maintaining a database of information utilizing user opinions about subjects, particularly exceptional experiences. Described is an Internet system assisting/motivating a population of users interested in information about certain categories of subjects to automatically maintain the database content and to improve the usefulness and quality of the database information without any substantial management by the website owner-manager. The user opinions are primarily in the form of both comments and ratings about which natural-language terms best describe a particular subject, enabling user searches of the subject database to be by way of preferred such descriptive natural-language terms, which terms are further preferred to be evaluative and approving.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1–C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, and C3–C6 cycloalkylaryl-C0-2-alkyl; W is O or S; X is an optionally substituted C1–C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; Y is C, O, S, NH or a single bond; E is C(R3)(R4)A or A

Abstract: A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.

Abstract: The inventive tape dispenser includes a cover and a base. The cover includes a forward section, a saddle, a rounded back section, and first and second sidewalls extending downwardly from the forward section and saddle. The forward section of the cover includes a first end from which a means for cutting extends. The base includes a semicircular tape holding portion having a first side opposite a second side, a mounting surface and an inner surface. The inner surface of the base includes a means for gripping the dispenser. The base also includes an arm, a land area extending at an angle from the arm and an edge extending an angle from the land area. The edge is disposed substantially parallel to and proximate to the second sidewall of the cover.