Patents by Inventor Cynthia A. Toth

Cynthia A. Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10973405
    Abstract: Systems and methods for long working distance optical coherence tomography (OCT). According to an aspect, an OCT system includes a reference arm. Further, the OCT system includes a sample arm operably connected to the reference arm. The sample arm includes a scanner configured to scan an optical beam. The sample arm also includes an objective positioned a predetermined distance from the scanner, configured to receive the optical beam, and to direct the optical beam to an object positioned at about the predetermined distance from the scanner for imaging of the object.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: April 13, 2021
    Assignee: Duke University
    Inventors: Oscar M. Carrasco-Zevallos, Justin Migacz, Cynthia A. Toth, Joseph A. Izatt
  • Publication number: 20210026127
    Abstract: Systems and methods of optical coherence tomography stereoscopic imaging for microsurgery visualization are disclosed. In accordance with an aspect, a method includes capturing a plurality of cross-sectional images of a subject. The method includes generating a stereoscopic left image and right image of the subject based on the cross-sectional images. Further, the method includes displaying the stereoscopic left image and the right image in a display of a microscope system.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 28, 2021
    Inventors: Oscar M. Carrasco-Zevallos, Brenton Keller, Liangbo Shen, Christian B. Viehland, Cynthia A. Toth, Joseph A. Izatt
  • Publication number: 20200315447
    Abstract: Optical coherence tomography (OCT) imaging systems, handhold probes, and methods that use a field curvature to match a curved surface of tissue are disclosed. According to an aspect, an OCT imaging system includes optical elements to generate diverging light. The system also includes one or more mirrors and a lens system configured to scan the diverging light onto a curved surface of an object for imaging of the object.
    Type: Application
    Filed: January 24, 2019
    Publication date: October 8, 2020
    Inventors: Christian VIEHLAND, Cynthia TOTH, Joseph IZATT
  • Patent number: 10366492
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: July 30, 2019
    Assignee: Duke University
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 10238279
    Abstract: Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion, and configured to display second images in the second display portion. The first image and the second image are projected along a first pathway and a second pathway. The system includes a first optical element positioned to relay the first images into the first eyepiece. The system includes a second optical element positioned to relay the second images into the second eyepiece.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 26, 2019
    Assignee: Duke University
    Inventors: Joseph A. Izatt, Liangbo Shen, Oscar M. Carrasco-Zevallos, Cynthia Toth
  • Publication number: 20180299658
    Abstract: Systems and methods of optical coherence tomography stereoscopic imaging for microsurgery visualization are disclosed. In accordance with an aspect, a method includes capturing a plurality of cross-sectional images of a subject. The method includes generating a stereoscopic left image and right image of the subject based on the cross-sectional images. Further, the method includes displaying the stereoscopic left image and the right image in a display of a microscope system.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 18, 2018
    Inventors: Oscar M. Carrasco-Zevallos, Brenton Keller, Liangbo Shen, Christian B. Viehland, Cynthia A. Toth, Joseph A. Izatt
  • Publication number: 20180296087
    Abstract: Systems and methods for long working distance optical coherence tomography (OCT). According to an aspect, an OCT system includes a reference arm. Further, the OCT system includes a sample arm operably connected to the reference arm. The sample arm includes a scanner configured to scan an optical beam. The sample arm also includes an objective positioned a predetermined distance from the scanner, configured to receive the optical beam, and to direct the optical beam to an object positioned at about the predetermined distance from the scanner for imaging of the object.
    Type: Application
    Filed: May 5, 2016
    Publication date: October 18, 2018
    Inventors: Oscar M. Carrasco-Zevallos, Justin Migacz, Cynthia A. Toth, Joseph A. Izatt
  • Patent number: 10004397
    Abstract: The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or SSOCT, with RBS technology that provides accurate information on the presence or absence of foveal fixation. Therefore, the present invention only analyzes data during foveal fixation. A system combining OCT with RBS is implemented such that both systems co-operate in a specified alignment, such that when the RBS fixation detection system detects alignment with the fovea of the eye, the OCT system will be aimed at the retinal region of interest, usually but not necessarily including the macular area.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: June 26, 2018
    Assignees: The Johns Hopkins University, Duke University
    Inventors: Boris Gramatikov, David Lee Guyton, Kristina Irsch, Cynthia Toth, Oscar Carrasco-Zevallos, Joseph Izatt
  • Publication number: 20180008140
    Abstract: Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion, and configured to display second images in the second display portion. The first image and the second image are projected along a first pathway and a second pathway. The system includes a first optical element positioned to relay the first images into the first eyepiece. The system includes a second optical element positioned to relay the second images into the second eyepiece.
    Type: Application
    Filed: February 5, 2016
    Publication date: January 11, 2018
    Inventors: Joseph A. Izatt, Liangbo Shen, Oscar M. Carrasco-Zevallos, Cynthia Toth
  • Publication number: 20170140544
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Application
    Filed: January 31, 2017
    Publication date: May 18, 2017
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 9589346
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Grant
    Filed: February 21, 2016
    Date of Patent: March 7, 2017
    Assignee: Duke University
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Josheph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Publication number: 20160235292
    Abstract: The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or SSOCT, with RBS technology that provides accurate information on the presence or absence of foveal fixation. Therefore, the present invention only analyzes data during foveal fixation. A system combining OCT with RBS is implemented such that both systems co-operate in a specified alignment, such that when the RBS fixation detection system detects alignment with the fovea of the eye, the OCT system will be aimed at the retinal region of interest, usually but not necessarily including the macular area.
    Type: Application
    Filed: October 2, 2014
    Publication date: August 18, 2016
    Inventors: Boris Gramatikov, David Lee Guyton, Kristina Irsch, Cynthia Toth, Oscar Carrasco-Zevallos, Joseph Izatt
  • Publication number: 20160171688
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Application
    Filed: February 21, 2016
    Publication date: June 16, 2016
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Josheph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 9299155
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: March 29, 2016
    Assignee: Duke University
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Publication number: 20150342460
    Abstract: Imaging and visualization systems, instruments, and methods using optical coherence tomography (OCT) are disclosed. A method for OCT image capture includes determining a location of a feature of interest within an operative field. The method also includes determining a relative positioning between the feature of interest and an OCT scan location. Further, the method includes controlling capture of an OCT image at a set position relative to the feature of interest based on the relative positioning.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 3, 2015
    Inventors: Joseph A. Izatt, Cynthia A. Toth, Sina Farsiu, Paul V. Hahn, Yuankai K. Tao, Justis P. Ehlers, Justin V. Migacz, Stephanie J. Chiu
  • Publication number: 20140334703
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 13, 2014
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 8811745
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: August 19, 2014
    Assignee: Duke University
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 8366271
    Abstract: A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: February 5, 2013
    Assignee: Duke University
    Inventors: Joseph A. Izatt, Yuankai K. Tao, Cynthia A. Toth
  • Publication number: 20120184846
    Abstract: Imaging and visualization systems, instruments, and methods using optical coherence tomography (OCT) are disclosed. A method for OCT image capture includes determining a location of a feature of interest within an operative field. The method also includes determining a relative positioning between the feature of interest and an OCT scan location. Further, the method includes controlling capture of an OCT image at a set position relative to the feature of interest based on the relative positioning.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 19, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Joseph A. Izatt, Cynthia A. Toth, Sina Farsiu, Paul Hahn, Yuankai K. Tao, Justis P. Ehlers, Justin V. Migacz, Stephanie J. Chiu
  • Patent number: 8180131
    Abstract: Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: May 15, 2012
    Assignee: Bioptigen, Inc.
    Inventors: Cynthia Toth, Eric Buckland, Bennett Groshong