Patents by Inventor Cynthia A. Toth
Cynthia A. Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160171688Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.Type: ApplicationFiled: February 21, 2016Publication date: June 16, 2016Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Josheph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
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Patent number: 9299155Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.Type: GrantFiled: July 21, 2014Date of Patent: March 29, 2016Assignee: Duke UniversityInventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
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Publication number: 20150342460Abstract: Imaging and visualization systems, instruments, and methods using optical coherence tomography (OCT) are disclosed. A method for OCT image capture includes determining a location of a feature of interest within an operative field. The method also includes determining a relative positioning between the feature of interest and an OCT scan location. Further, the method includes controlling capture of an OCT image at a set position relative to the feature of interest based on the relative positioning.Type: ApplicationFiled: August 11, 2015Publication date: December 3, 2015Inventors: Joseph A. Izatt, Cynthia A. Toth, Sina Farsiu, Paul V. Hahn, Yuankai K. Tao, Justis P. Ehlers, Justin V. Migacz, Stephanie J. Chiu
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Publication number: 20140334703Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.Type: ApplicationFiled: July 21, 2014Publication date: November 13, 2014Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
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Patent number: 8811745Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.Type: GrantFiled: January 20, 2011Date of Patent: August 19, 2014Assignee: Duke UniversityInventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
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Patent number: 8366271Abstract: A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter.Type: GrantFiled: January 20, 2011Date of Patent: February 5, 2013Assignee: Duke UniversityInventors: Joseph A. Izatt, Yuankai K. Tao, Cynthia A. Toth
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Publication number: 20120184846Abstract: Imaging and visualization systems, instruments, and methods using optical coherence tomography (OCT) are disclosed. A method for OCT image capture includes determining a location of a feature of interest within an operative field. The method also includes determining a relative positioning between the feature of interest and an OCT scan location. Further, the method includes controlling capture of an OCT image at a set position relative to the feature of interest based on the relative positioning.Type: ApplicationFiled: January 19, 2012Publication date: July 19, 2012Applicant: DUKE UNIVERSITYInventors: Joseph A. Izatt, Cynthia A. Toth, Sina Farsiu, Paul Hahn, Yuankai K. Tao, Justis P. Ehlers, Justin V. Migacz, Stephanie J. Chiu
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Patent number: 8180131Abstract: Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.Type: GrantFiled: May 2, 2008Date of Patent: May 15, 2012Assignee: Bioptigen, Inc.Inventors: Cynthia Toth, Eric Buckland, Bennett Groshong
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Publication number: 20120092615Abstract: A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter.Type: ApplicationFiled: January 20, 2011Publication date: April 19, 2012Inventors: Joseph A. Izatt, Yuankai K. Tao, Cynthia A. Toth
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Publication number: 20110182517Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.Type: ApplicationFiled: January 20, 2011Publication date: July 28, 2011Applicant: DUKE UNIVERSITYInventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
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Patent number: 7593559Abstract: A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. it is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.Type: GrantFiled: November 17, 2006Date of Patent: September 22, 2009Assignee: Duke UniversityInventors: Cynthia A. Toth, Marcin Stopa, Bradley A. Bower
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Publication number: 20080273783Abstract: Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.Type: ApplicationFiled: May 2, 2008Publication date: November 6, 2008Inventors: Cynthia Toth, Eric Buckland, Bennett Groshong
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Publication number: 20070123768Abstract: Ophthalmic instruments, systems and methods enable tonometry and pachymetry measurements to be conducted simultaneously. As such, a patient's intraocular pressure (IOP) corrected for corneal thickness may be determined accurately by a single corneal applanation. Preferably, the ophthalmic instruments have a reference surface at a distal end of the instrument, an applanation plate spaced from the reference surface, and a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface. The instrument most preferably has a housing such that the reference surface is located at a fixed position at one end of the housing, and the applanation plate is mounted to that one end of the housing in coaxial spaced alignment relative to the reference surface by means of the compliant mount.Type: ApplicationFiled: November 30, 2005Publication date: May 31, 2007Inventors: Sharon Freedman, Phillip McKinley, Pratap Challa, Leon Herndon, Cynthia Toth, Ronald Overaker, Brian Dodge, Brian Applegate, Joseph Izatt
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Publication number: 20070115481Abstract: A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. It is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.Type: ApplicationFiled: November 17, 2006Publication date: May 24, 2007Applicant: Duke UniversityInventors: Cynthia Toth, Marcin Stopa, Bradley Bower
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Publication number: 20060089661Abstract: Hand-held instruments which may be employed to actuate a distally mounted tool by application of radial compressive force about the instrument circumference (i.e., omni-actuatable). In preferred forms, hand-held instruments have a handle and a slide ring assembly attached to the handle which defines a generally V-shaped circumferential channel. The slide ring assembly will have at least one slide ring mounted for longitudinal movements relative to the handle. An actuator member is operatively engaged with the slide ring assembly for moving the slide ring longitudinally relative to the handle in response to a force applied against the actuator member. In preferred embodiments, the actuator member is tubular and includes at least one actuation finger, and more preferably a circumferentially disposed plurality of actuation fingers. The actuator member includes a tubular proximal end section thereof sleeved over the handle so as to be located proximally of the slide ring assembly.Type: ApplicationFiled: May 5, 2003Publication date: April 27, 2006Inventors: Brian Dodge, Ronald Overaker, Cynthia Toth
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Publication number: 20050105877Abstract: Optical fiber illuminators are embodied in light-diffusing particles affixed to an optical fiber's terminal end. Most preferably, the light-diffusing particles are optically transparent solid particles dispersed symmetrically or asymmetrically in an optically transparent bonding material to thereby form a light diffusion medium (LDM). The solid particles may thus be dispersed in the bonding material while the bonding material is in a liquid state to form the LDM. A mass of the LDM may thus be applied onto the terminal optical fiber end while the bonding material is in such a liquid state. Allowing the bonding material to solidify will therefore affix the light-diffusing particles to the terminal end of the optical fiber. In such a manner, optical fiber illuminators having high light throughput and diffusion may be made.Type: ApplicationFiled: November 13, 2003Publication date: May 19, 2005Applicant: Duke UniversityInventors: Richard Nappi, Ronald Overaker, Cynthia Toth, Brian Dodge, Hoang Ngyuen, Katrina Winter
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Patent number: 6616683Abstract: Miniature surgical forceps are formed from a one-piece tubular member by opposed longitudinal channels machined in a distal end thereof so as to establish a radially opposed pair of unitary forceps jaws. Most preferably, the opposed channels are formed in the distal end of the rigid tubular member by means of electron discharge machining (EDM) techniques. The resulting opposed cross-sectionally arcuate jaw sections may be bent and/or further shaped to achieve the desired final jaw configuration. The inner surfaces of the forceps jaws thereby established may have a filler material deposited in such a manner so as to change the overall shape and/or geometric configuration of the jaws and thereby engineer them to a specific surgical purpose.Type: GrantFiled: May 2, 2000Date of Patent: September 9, 2003Assignee: Duke UniversityInventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge, Brooks W. McCuen
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Publication number: 20030139342Abstract: The present invention relates, in general, to a method of treating disorders of the eye, and, in particular, to a method of inducing posterior vitreous detachment.Type: ApplicationFiled: October 22, 2002Publication date: July 24, 2003Inventors: Brooks W. McCuen, Cynthia A. Toth, David Epstein, Leonardo deOliveira, Misako Tatebayashi, Carsten H. Meyer, Janardan Kumar
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Patent number: 6540390Abstract: A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner base member and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base member.Type: GrantFiled: April 17, 2002Date of Patent: April 1, 2003Assignee: Duke UniversityInventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge
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Patent number: 6517560Abstract: Hand-held surgical instruments include magnetic couplings which impart simultaneous reciprocal rotary and longitudinal motions or oscillations to a distally located workpiece. In preferred embodiments, the magnetic couplings include a drive shaft, an output shaft coaxially aligned with the drive shaft relative to a central axis, and drive and driven magnet assemblies connected operatively to the drive and output shafts, respectively. The drive and driven magnet assemblies include permanent magnets arranged to translate continuous rotation of the drive shaft into simultaneous rotary and longitudinal movements of the driven magnet assembly relative to the drive axis. A resilient support member exhibiting torsional and longitudinal resiliency (e.g., an annular elastomeric disc) is most preferably operatively connected to the output shaft to allow for such simultaneous rotary and longitudinal movements thereof.Type: GrantFiled: November 27, 2000Date of Patent: February 11, 2003Assignee: Duke UniversityInventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge, Robert Machemer