Patents by Inventor Cynthia A. Toth

Cynthia A. Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120092615
    Abstract: A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter.
    Type: Application
    Filed: January 20, 2011
    Publication date: April 19, 2012
    Inventors: Joseph A. Izatt, Yuankai K. Tao, Cynthia A. Toth
  • Publication number: 20110182517
    Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 28, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Sina Farsiu, Stephanie J. Chiu, Cynthia A. Toth, Joseph A. Izatt, Xiao T. Li, Peter Christopher Nicholas
  • Patent number: 7593559
    Abstract: A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. it is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: September 22, 2009
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Marcin Stopa, Bradley A. Bower
  • Publication number: 20080273783
    Abstract: Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.
    Type: Application
    Filed: May 2, 2008
    Publication date: November 6, 2008
    Inventors: Cynthia Toth, Eric Buckland, Bennett Groshong
  • Publication number: 20070123768
    Abstract: Ophthalmic instruments, systems and methods enable tonometry and pachymetry measurements to be conducted simultaneously. As such, a patient's intraocular pressure (IOP) corrected for corneal thickness may be determined accurately by a single corneal applanation. Preferably, the ophthalmic instruments have a reference surface at a distal end of the instrument, an applanation plate spaced from the reference surface, and a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface. The instrument most preferably has a housing such that the reference surface is located at a fixed position at one end of the housing, and the applanation plate is mounted to that one end of the housing in coaxial spaced alignment relative to the reference surface by means of the compliant mount.
    Type: Application
    Filed: November 30, 2005
    Publication date: May 31, 2007
    Inventors: Sharon Freedman, Phillip McKinley, Pratap Challa, Leon Herndon, Cynthia Toth, Ronald Overaker, Brian Dodge, Brian Applegate, Joseph Izatt
  • Publication number: 20070115481
    Abstract: A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. It is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.
    Type: Application
    Filed: November 17, 2006
    Publication date: May 24, 2007
    Applicant: Duke University
    Inventors: Cynthia Toth, Marcin Stopa, Bradley Bower
  • Publication number: 20060089661
    Abstract: Hand-held instruments which may be employed to actuate a distally mounted tool by application of radial compressive force about the instrument circumference (i.e., omni-actuatable). In preferred forms, hand-held instruments have a handle and a slide ring assembly attached to the handle which defines a generally V-shaped circumferential channel. The slide ring assembly will have at least one slide ring mounted for longitudinal movements relative to the handle. An actuator member is operatively engaged with the slide ring assembly for moving the slide ring longitudinally relative to the handle in response to a force applied against the actuator member. In preferred embodiments, the actuator member is tubular and includes at least one actuation finger, and more preferably a circumferentially disposed plurality of actuation fingers. The actuator member includes a tubular proximal end section thereof sleeved over the handle so as to be located proximally of the slide ring assembly.
    Type: Application
    Filed: May 5, 2003
    Publication date: April 27, 2006
    Inventors: Brian Dodge, Ronald Overaker, Cynthia Toth
  • Publication number: 20050105877
    Abstract: Optical fiber illuminators are embodied in light-diffusing particles affixed to an optical fiber's terminal end. Most preferably, the light-diffusing particles are optically transparent solid particles dispersed symmetrically or asymmetrically in an optically transparent bonding material to thereby form a light diffusion medium (LDM). The solid particles may thus be dispersed in the bonding material while the bonding material is in a liquid state to form the LDM. A mass of the LDM may thus be applied onto the terminal optical fiber end while the bonding material is in such a liquid state. Allowing the bonding material to solidify will therefore affix the light-diffusing particles to the terminal end of the optical fiber. In such a manner, optical fiber illuminators having high light throughput and diffusion may be made.
    Type: Application
    Filed: November 13, 2003
    Publication date: May 19, 2005
    Applicant: Duke University
    Inventors: Richard Nappi, Ronald Overaker, Cynthia Toth, Brian Dodge, Hoang Ngyuen, Katrina Winter
  • Patent number: 6616683
    Abstract: Miniature surgical forceps are formed from a one-piece tubular member by opposed longitudinal channels machined in a distal end thereof so as to establish a radially opposed pair of unitary forceps jaws. Most preferably, the opposed channels are formed in the distal end of the rigid tubular member by means of electron discharge machining (EDM) techniques. The resulting opposed cross-sectionally arcuate jaw sections may be bent and/or further shaped to achieve the desired final jaw configuration. The inner surfaces of the forceps jaws thereby established may have a filler material deposited in such a manner so as to change the overall shape and/or geometric configuration of the jaws and thereby engineer them to a specific surgical purpose.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: September 9, 2003
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge, Brooks W. McCuen
  • Publication number: 20030139342
    Abstract: The present invention relates, in general, to a method of treating disorders of the eye, and, in particular, to a method of inducing posterior vitreous detachment.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 24, 2003
    Inventors: Brooks W. McCuen, Cynthia A. Toth, David Epstein, Leonardo deOliveira, Misako Tatebayashi, Carsten H. Meyer, Janardan Kumar
  • Patent number: 6540390
    Abstract: A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner base member and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base member.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: April 1, 2003
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge
  • Patent number: 6517560
    Abstract: Hand-held surgical instruments include magnetic couplings which impart simultaneous reciprocal rotary and longitudinal motions or oscillations to a distally located workpiece. In preferred embodiments, the magnetic couplings include a drive shaft, an output shaft coaxially aligned with the drive shaft relative to a central axis, and drive and driven magnet assemblies connected operatively to the drive and output shafts, respectively. The drive and driven magnet assemblies include permanent magnets arranged to translate continuous rotation of the drive shaft into simultaneous rotary and longitudinal movements of the driven magnet assembly relative to the drive axis. A resilient support member exhibiting torsional and longitudinal resiliency (e.g., an annular elastomeric disc) is most preferably operatively connected to the output shaft to allow for such simultaneous rotary and longitudinal movements thereof.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: February 11, 2003
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge, Robert Machemer
  • Patent number: 6491670
    Abstract: Surgical instruments, especially for opthalmological surgical procedures, have a smooth, bulbous arcuate tip that surrounds the distal end of a lumen. The tip may be translucent and flexible. Most preferably, the tip is formed of a compliant, yet self-supporting, material, such as medical grade transparent silicone elastomer. The bulbous arcuate tip may take various geometric forms, for example, generally spherical, ellipsoid or the like. The bulbous arcuate tip may be symmetrical about the elongate axis of the instrument or may be asymmetrical (i.e., angularly disposed) relative to such longitudinal axis. The surgical instruments of this invention are most preferably made by first adhering a length of compliant tubing (e.g., silicone) onto a distal end of a rigid tube (e.g., a section of a stainless steel needle). The proximal rigid tube section is preferably coaxially sleeved over, and affixed to, the distal compliant tube section.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: December 10, 2002
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge, Eric A. Postel, Brooks W. McCuen
  • Patent number: 6482198
    Abstract: Hand-held instruments have an actuator assembly which may be employed to actuate a distally mounted tool by application of radial force about the entirety of the instrument circumference (i.e., is omni-actuatable). Most preferably, the actuator assembly includes a plurality of circumferentially spaced-apart generally L-shaped actuator levers defining respective arcuate bearing surfaces along exterior edge regions thereof, and a retaining ring which circumferentially bounds the actuator levers around the exterior edge regions thereof. The retaining ring most preferably defines an interior stationary arcuate guide surface in conformable mated relationship to the bearing surfaces of said actuator levers.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 19, 2002
    Assignee: Duke University
    Inventors: Ronald F. Overaker, Cynthia A. Toth, Brian C. Dodge, Brooks W. McCuen, Glenn J. Jaffe, Eric A. Postal, Sharon Fekrat
  • Patent number: 6478681
    Abstract: Magnetic couplings impart simultaneous reciprocal rotary and longitudinal motions or oscillations to a work element. In preferred embodiments, the magnetic couplings include a drive shaft, an output shaft coaxially aligned with the drive shaft relative to a central axis, and drive and driven magnet assemblies connected operatively to the drive and output shafts, respectively. The drive and driven magnet assemblies include permanent magnets arranged to translate continuous rotation of the drive shaft into simultaneous rotary and longitudinal movements of the driven magnet assembly relative to the drive axis. A resilient support member exhibiting torsional and longitudinal resiliency (e.g., an annular elastomeric disc) is most preferably operatively connected to the output shaft to allow for such simultaneous rotary and longitudinal movements thereof.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 12, 2002
    Assignee: Duke University
    Inventors: Ronald F. Overaker, Brian C. Dodge, Robert Machemer, Cynthia A. Toth
  • Publication number: 20020156465
    Abstract: Hand-held instruments have an actuator assembly which may be employed to actuate a distally mounted tool by application of radial force about the entirety of the instrument circumference (i.e., is omni-actuatable). Most preferably, the actuator assembly includes a plurality of circumferentially spaced-apart generally L-shaped actuator levers defining respective arcuate bearing surfaces along exterior edge regions thereof, and a retaining ring which circumferentially bounds the actuator levers around the exterior edge regions thereof. The retaining ring most preferably defines an interior stationary arcuate guide surface in conformable mated relationship to the bearing surfaces of said actuator levers.
    Type: Application
    Filed: April 19, 2001
    Publication date: October 24, 2002
    Inventors: Ronald F. Overaker, Cynthia A. Toth, Brian C. Dodge, Brooks W. McCuen, Glenn J. Jaffe, Eric A. Postel, Sharon Fekrat
  • Publication number: 20020126501
    Abstract: A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner core and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base.
    Type: Application
    Filed: April 17, 2002
    Publication date: September 12, 2002
    Applicant: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge
  • Patent number: 6436035
    Abstract: A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner base member and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base member.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: August 20, 2002
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge
  • Patent number: 6270491
    Abstract: A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner core and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: August 7, 2001
    Assignee: Duke University
    Inventors: Cynthia A. Toth, Ronald F. Overaker, Brian C. Dodge
  • Patent number: 6039691
    Abstract: Soft tissue examination apparatus and method employ an ultrasonic transducer system for generating a series of ultrasound pulses, at least one of which is of sufficiently high intensity to induce physical displacement of the soft tissue. The transducer receives a series of ultrasonic echo pulses and responsively generates a series of data signals indicative of such tissue displacement. A data processor receives the data signals and determines the magnitude of the displacement. In such a manner, the present invention assists in the evaluation and/or diagnosis of biological tissue. Preferably, the apparatus and method of this invention is employed to examine the properties of a subject's vitreous body and thus may be used in the evaluation and/or diagnosis of ocular disorders, such as vitreous traction.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: March 21, 2000
    Assignees: Duke University, Novason Corporation
    Inventors: William F. Walker, Cynthia A. Toth, Richard E. Davidsen