Abstract: A medical system may include an elongated flexible body including a channel extending through the elongated flexible body. The elongated flexible body includes an articulable portion extending along at least a portion of a length of the elongated flexible body. The medical system may include an instrument configured to be received in the channel of the elongated flexible body, a magnetic field generator configured to generate a magnetic field within the channel, and a magnetic field sensor configured to detect the magnetic field generated by the magnetic field generator.

Abstract: The invention provides a method of treating a subject afflicted with a dystonia, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine effective to treat the subject.

Abstract: An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

Abstract: A system to verify the identity of a recipient requesting fulfillment of a prescription for a pharmaceutical product includes a point-of-sale retail personal identification number entry device (pinpad) and a workstation that stop a transaction for the pharmaceutical product from proceeding in response to a request associated with a claim for dispensing the pharmaceutical product. A first input for data identifying a member of a rewards program is entered with the pinpad, and a second input for data identifying a recipient of the prescription is entered with the workstation. The workstation compares the data identifying the member of the rewards program against the data identifying the recipient of the prescription. If there is a match between the data identifying the member of the rewards program and the data identifying the recipient of the prescription, the pinpad and workstation allow the transaction for the pharmaceutical product to proceed.

Abstract: An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

Abstract: A prosthetic implant for engagement between first and second vertebrae. The implant includes a first plate configured for attachment to the first vertebrae and defining a first interbody connection member and a second plate configured for attachment to the second vertebrae and defining a second interbody connection member. An interbody component includes a body with a first end defining a first plate connection member configured for connection to the first interbody connection member and a second end defining a second plate connection member configured for connection to the second interbody connection member. A method of inserting the implant is also provided.

Abstract: The present disclosure is directed to an exterior surface protective layer for protecting a composite structure from environmental conditions including: at least one curable film; such as at least two curable films, and an electrically conductive material, wherein the electrically conductive material comprises a wire-free electrically conductive material, and/or an electrically conductive polymer weave, wherein the at least one curable film includes at least one of polyurethane, polyimide, polyester or epoxy upon curing, and wherein a weight of the exterior surface protective layer ranges from about 0.02 pounds per square foot to about 0.1 pounds per square foot. An exterior surface protected composite structure and methods of forming an exterior surface protected composite structure are also provided.

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

Abstract: A prosthetic implant for engagement between first and second vertebrae. The implant includes a first plate configured for attachment to the first vertebrae and defining a first interbody connection member and a second plate configured for attachment to the second vertebrae and defining a second interbody connection member. An interbody component includes a body with a first end defining a first plate connection member configured for connection to the first interbody connection member and a second end defining a second plate connection member configured for connection to the second interbody connection member. A method of inserting the implant is also provided.

Abstract: Co-curable epoxy-based composite materials coated with co-curable polyurethane-based coating materials to form co-curable and co-cured polyurethane coated epoxy-based composite materials, with the polyurethane-based coating materials comprising UV-stabilizer agents and cure control agents are disclosed, along with components and large structures comprising the co-cured materials.

Abstract: The present disclosure is directed to a method for applying a multi-colored coating to a composite structure comprising applying a first co-curable film layer comprising a first color marking to a composite tool, applying a second co-curable film layer comprising a second color marking over the composite tool and at least partially over the first co-curable film layer to create a lay-up of a multi-colored marking, applying a composite structure over the lay-up of the multi-colored marking, and curing the lay-up of the multi-colored marking and the composite structure in a single curing step to create a cured multi-colored coating on the composite structure. A multi-colored coating for marking a composite structure and an aircraft part having a multi-colored marking are also provided.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: The present disclosure is directed to a method for reactivating a co-cured film layer disposed on a composite structure, the method comprising applying a reactivation treatment composition comprising at least two solvents and a surface exchange agent comprising a metal alkoxide or chelate thereof to the co-cured film layer, and allowing the reactivation treatment composition to create a reactivated co-cured film layer, wherein the co-cured film layer was previously cured at a curing temperature greater than about 50° C. A reactivated co-cured film layer and an aircraft part having a reactivated co-cured film layer are also provided.

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

Abstract: An ultrasonic inspection system, method, and software. In one embodiment, the ultrasonic inspection system includes an ultrasonic probe that directs ultrasound waves into a structure from a front wall, and receives reflected waves to generate a response signal. The system further includes a processor that rectifies the response signal to generate a rectified signal, integrates a portion of the rectified signal within a detection time window to determine an energy sum, and generates output based on the energy sum. The detection time window is restricted to a front wall reflection and at least a portion of a near-surface dead zone following the front wall reflection.

Abstract: Disclosed are methods and coatings for protecting the surface of a non-metallic composite part, comprising applying a protective layer to an exposed surface of the non-metallic composite part, the protective layer comprising: (a) a multilayer having at least a co-cured layer applied to the surface of the non-metallic part and laser-sensitive layer applied to a surface of the co-cured layer, wherein the laser-sensitive layer is selected from a reflective layer, an optical sensor layer or a layer having both reflective and optical sensor properties; or (b) a co-cured coating which comprises a laser-sensitive material incorporated therein to form a laser-sensitive co-cured layer applied to a surface of the non-metallic composite part, wherein the laser-sensitive material is selected from a reflective material, an optical sensor material or a combination thereof, such that the non-metallic composite part will be protected from damage during subsequent laser ablation to remove an outer coating.

Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: A user interface of a computing device for programming a medical device configured to review historical user session data while disconnected from the medical device. During a programming session, the user interface on the computing device may include features to control the functionality of the medical device as well as view and manipulate available data stored at the medical device. The user interface may interactively view screens and features and manipulate data using the programming user interface, e.g., as if the external programming device were in a live programming session with the medical device, but while disconnected from the medical device and not in a live programming session. As one example, the user interface of the external programming device may permit flexible, extensive manipulation and viewing of sensed signals, patient events, and operational information, such as patient adjustments made over time or coincident with particular signals or events.

Abstract: Systems and methods for a flexible container for transport and storage of a working material are described herein. The material can be a viscous or liquid material when dispensed. The flexible container can be configured to move between a first shape and a second shape. The first shape can allow for efficient transport of the flexible container while the second shape can allow for the flexible container to couple to a dispenser. In certain examples, the flexible container can be cooled for transport and heated for dispensing.

Abstract: An ultrasonic inspection system, method, and software. In one embodiment, the ultrasonic inspection system includes an ultrasonic probe that directs ultrasound waves into a structure from a front wall, and receives reflected waves to generate a response signal. The system further includes a processor that rectifies the response signal to generate a rectified signal, integrates a portion of the rectified signal within a detection time window to determine an energy sum, and generates output based on the energy sum. The detection time window is restricted to a front wall reflection and at least a portion of a near-surface dead zone following the front wall reflection.