Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: The present disclosure is directed to a method for reactivating a co-cured film layer disposed on a composite structure, the method comprising applying a reactivation treatment composition comprising at least two solvents and a surface exchange agent comprising a metal alkoxide or chelate thereof to the co-cured film layer, and allowing the reactivation treatment composition to create a reactivated co-cured film layer, wherein the co-cured film layer was previously cured at a curing temperature greater than about 50° C. A reactivated co-cured film layer and an aircraft part having a reactivated co-cured film layer are also provided.

Abstract: Systems and methods for a container for decreasing the thawing time for a liquid, gel or other fluid material is described herein. The systems can include a container with a body. The body can include a cavity with a dispensing nozzle and a plunger disposed within the cavity. The body can further include one or more channels separate from the cavity. The channel(s) increases the rate of heat transfer associated with the container and, thus, increases the cooling or heating rate of the material within the container.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: Embodiments of the present disclosure relate to a substrate integrated waveguide monopulse antenna. The antenna comprises a substrate having first and second opposing surfaces. A first conductor is disposed on the first surface of the substrate. A plurality of antenna elements are provided on the first surface of the substrate. A second conductor is disposed on the second surface of the substrate. A plurality of conductive via holes extend through said substrate and extend between the first and second surfaces. The via holes are arranged to form a plurality of resonant cavities with at least one resonant cavity coupled to each of the antenna elements. The substrate also comprises a plurality of hybrid couplers, and two of the plurality of resonant cavities are coupled to at least one port of the plurality of hybrid couplers. A plurality of output couplers provided on the second surface of the substrate.

Abstract: Systems and methods for inferring user traits based on indirect questions. Indirect questions may be generated based on one or more triggers. The answers to the indirect questions provide cues to a system as to whether a user has one or more attributes associated with a trait. This information may be used to personalize a computing device.

Abstract: Systems and methods for a container for decreasing the thawing time for a liquid, gel or other fluid material is described herein. The systems can include a container with a body. The body can include a cavity with a dispensing nozzle and a plunger disposed within the cavity. The body can further include one or more channels separate from the cavity. The channel(s) increases the rate of heat transfer associated with the container and, thus, increases the cooling or heating rate of the material within the container.

Abstract: The present disclosure is directed to a method for applying a multi-colored coating to a composite structure comprising applying a first co-curable film layer comprising a first color marking to a composite tool, applying a second co-curable film layer comprising a second color marking over the composite tool and at least partially over the first co-curable film layer to create a lay-up of a multi-colored marking, applying a composite structure over the lay-up of the multi-colored marking, and curing the lay-up of the multi-colored marking and the composite structure in a single curing step to create a cured multi-colored coating on the composite structure. A multi-colored coating for marking a composite structure and an aircraft part having a multi-colored marking are also provided.

Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: Systems and methods for a flexible container for transport and storage of a working material are described herein. The material can be a viscous or liquid material when dispensed. The flexible container can be configured to move between a first shape and a second shape. The first shape can allow for efficient transport of the flexible container while the second shape can allow for the flexible container to couple to a dispenser. In certain examples, the flexible container can be cooled for transport and heated for dispensing.

Abstract: The present disclosure is directed to an exterior surface protective layer for protecting a composite structure from environmental conditions including: at least one curable film; such as at least two curable films, and an electrically conductive material, wherein the electrically conductive material comprises a wire-free electrically conductive material, and/or an electrically conductive polymer weave, wherein the at least one curable film includes at least one of polyurethane, polyimide, polyester or epoxy upon curing, and wherein a weight of the exterior surface protective layer ranges from about 0.02 pounds per square foot to about 0.1 pounds per square foot. An exterior surface protected composite structure and methods of forming an exterior surface protected composite structure are also provided.

Abstract: A prosthetic implant for engagement between first and second vertebrae. The implant includes a first plate configured for attachment to the first vertebrae and defining a first interbody connection member and a second plate configured for attachment to the second vertebrae and defining a second interbody connection member. An interbody component includes a body with a first end defining a first plate connection member configured for connection to the first interbody connection member and a second end defining a second plate connection member configured for connection to the second interbody connection member. A method of inserting the implant is also provided.

Abstract: Co-curable epoxy-based composite materials coated with co-curable polyurethane-based coating materials to form co-curable and co-cured polyurethane coated epoxy-based composite materials, with the polyurethane-based coating materials comprising UV-stabilizer agents and cure control agents are disclosed, along with components and large structures comprising the co-cured materials.

Abstract: A composite structure having a co-curable or co-cured coated epoxy-based composite material coated with a co-curable epoxy-based adhesive surfacing material layer and a polyurethane-based coating material layer, along with components and large objects including the co-curable or co-cured coated epoxy-based composite structures.

Abstract: An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

Abstract: An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Abstract: A prosthetic implant for engagement between first and second vertebrae. The implant includes a first plate configured for attachment to the first vertebrae and defining a first interbody connection member and a second plate configured for attachment to the second vertebrae and defining a second interbody connection member. An interbody component includes a body with a first end defining a first plate connection member configured for connection to the first interbody connection member and a second end defining a second plate connection member configured for connection to the second interbody connection member. A method of inserting the implant is also provided.