Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful in treating cancer.

Abstract: Herein are disclosed indazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: The present invention provides methods for improving gut health. In particular, the invention provides methods for improving gut health by improving the digestibility of dietary proteins, decreasing the flow of protein to the lower gastrointestinal tract, and/or decreasing the levels of Clostridium bacteria the upper intestinal tract of a subject. The methods comprise administering to the subject a supplement consisting essentially of at least one protease.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: A method for removing contaminants in a fuel cell comprises: supplying a hydrogen-based fuel to the anode; supplying a first oxidant to the cathode, wherein the first oxidant comprises at least some sulfur dioxide; drawing a primary load from the fuel cell stack while supplying the hydrogen-based fuel to the anode and the air to the cathode; shutting down the fuel cell when a voltage of the fuel cell is equal to or less than a threshold voltage at which sulfur crosses over from the cathode to the anode, wherein shutting down the fuel cell comprises: performing at least one oxidant starvation while drawing the primary load, removing the primary load after performing the at least one oxidant starvation, and bringing the anode to a high potential after removing the primary load; and thereafter, restarting the fuel cell.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: A portable, hand-held, non-contact surface measuring system comprises an image capturing element, at least four projectable reference elements positioned parallel to one another at known locations around the image capturing element, a processing unit, and a user interface. The invention further discloses a method for the noncontact surface measurement comprising projecting at least four references onto a target surface, capturing an image of the targeted surface and the projected references with the image transferring device, transferring the image to a processing unit, processing the image using triangulation-based computer vision techniques to correct for skew and to obtain surface measurement data, transferring the data to the user interface, modifying the data with the user interface. The systems and methods for the measurement of surfaces can be applied to the measurement of biological surfaces, such as skin, wounds, lesions, and ulcers.

Abstract: A computer-implemented method of automatically configuring a platform of storage devices includes querying components of the platform to gather information about the capability of the platform, locating one or more storage devices within the platform, automatically determining one or more RAID levels that are supported by the platform, and automatically configuring one or more storage devices within the platform as a RAID system having a particular RAID level, where the particular RAID level is selected based on the capability of the platform.

Abstract: Power plant systems and processes are described that enable recovery of at least a portion of the fuel storage energy associated with a storage system for supplying fuel to the power plant systems. A first embodiment of an energy-recovery power plant system includes at least one fuel storage container and at least one expander that can receive fuel from the fuel storage container at a first pressure and provide the fuel to the power plant at a second pressure that is lower than the first pressure. A second embodiment of an energy-recovery power plant system includes a first conduit fluidly coupling the fuel storage container and the power plant for delivering fuel from the fuel storage container to the power plant and at least one regenerative thermodynamic cycle engine thermally coupled to the first conduit such that heat may be exchanged between the fuel and a working fluid for the regenerative thermodynamic cycle engine.

Abstract: A tooth retention device for attachment to an excavator bucket, which has a tooth mounting portion, a fork shaped body fitting over the edge of the bucket, a clamp passing through the body and the bucket, and a wedge holding the clamp in position, in which the wedge has a threaded rod and a threaded block on the rod. The rod is rotatable to move the block between locked and released positions.

Abstract: The present invention provides methods and compositions for detecting and correcting errors in nucleic acid amplification processes, and methods for using the same. In particular, barcode amplification errors are detected and corrected such that integrity in sample assignment is maintained. The methods are compatible with high throughput sequencing techniques as some of the barcodes are based upon Hamming codes, thereby allowing self-correction for single bit errors. Some methods and compositions of the invention allow characterization (e.g., sequencing) of a plurality of nucleic acid samples simultaneously within a single sequencing reaction.

Abstract: Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

Abstract: A computer-implemented method of automatically configuring a platform of storage devices includes querying components of the platform to gather information about the capability of the platform, locating one or more storage devices within the platform, automatically determining one or more RAID levels that are supported by the platform, and automatically configuring one or more storage devices within the platform as a RAID system having a particular RAID level, where the particular RAID level is selected based on the capability of the platform.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

Abstract: Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.