Abstract: A significant problem in PEM fuel cell durability is in premature failure of the ion-exchange membrane and in particular by the degradation of the ion-exchange membrane by reactive hydrogen peroxide species. Such degradation can be reduced or eliminated by the presence of an additive in the anode, cathode or ion-exchange membrane. The additive may be a radical scavenger, a membrane cross-linker, a hydrogen peroxide decomposition catalyst and/or a hydrogen peroxide stabilizer. The presence of the additive in the membrane electrode assembly (MEA) may however result in reduced performance of the PEM fuel cell. Accordingly, it may be desirable to restrict the location of the additive to locations of increased susceptibility to membrane degradation such as the inlet and/or outlet regions of the MEA.

Abstract: Provided herein are certain substituted N-phenethylbenzamide of formula V: that may be useful for treating certain cellular proliferation diseases and disorders by modulating the activity of CENP-E.

Abstract: In a solid polymer fuel cell series, various circumstances can result in a fuel cell being driven into voltage reversal. For instance, cell voltage reversal can occur if that cell receives an inadequate supply of fuel. In order to pass current, reactions other than fuel oxidation may take place at the fuel cell anode, including water electrolysis and oxidation of anode components. The latter may result in significant degradation of the anode, particularly if the anode employs a carbon black supported catalyst. Such fuel cells can be made more tolerant to cell reversal by using higher catalyst loading or coverage on the anode catalyst support or a more oxidation resistant anode catalyst support, such as a more graphitic carbon or Ti4O7.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: A caller places a telephone call and enters an access code when calling a subscriber. The caller's access code signal is generated by the caller when the caller inputs his or her access code. The call is transmitted over the Public Switched Telephone Network to a subscriber's telephone number. A Call Router Server capable of receiving the caller's telephone call and the caller's access code signal is provided. The Call Router Server detects the caller's access code signal and then directing the caller's telephone call to the subscriber to be completed in a particular manner based upon the caller's access code. An Access Code Server which is Web server is provided that allows a subscriber to input the manner in which incoming telephone calls will be received and completed based upon the access code signal that is received by the Call Router Server. This information is stored on a Database Server, which instructs the Call Router Server on the proper routing pattern of the incoming telephone call.

Abstract: Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.

Abstract: An electrochemical fuel cell stack comprises a plurality of fuel cell assemblies, wherein, each fuel cell assembly comprises a cell compressed between a pair of flow field plates, a perimeter seal circumscribing the cell and interposed between the pair of flow field plates, and a first diode, having an aspect ratio greater than 10:1, positioned adjacent to, and outside of, the perimeter seal along a first edge of the cell and interposed between the pair of flow field plates.

Abstract: A side-gusseted bag having a slider-operated zipper. The zipper parts are joined only at one end, the free ends of the zipper parts being separable to allow the associated side gusset of the bag to be inverted to form a pouring spout. The zipper flanges at the joined ends of the zipper are inserted in a corner formed by one gusset panel and an opposing portion of the bag wall. The other gusset panel is sealed to the other bag wall at the elevation of the zipper flanges.

Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

Abstract: Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The present invention also relates to the complex formed from the binding of such mimic compounds to the hydrophobic groove of a pilus subunit. Competitively interacting with the binding site of pili subunits will negatively affect the chaperone/usher pathway, which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures, and thus prevent or inhibit pilus assembly.

Abstract: An ultrasonic welding assembly comprising a horn, an anvil and an anvil cover. The horn comprises a generally T-shaped flattening surface and a rail projecting forward of the flattening surface. The rail is shaped to serve as a dam for flowing thermoplastic zipper material during stomping of slider end stops. The horn further comprises a plurality of vertical energy directors designed to direct ultrasonic energy into the mass of zipper material and deflect flowing zipper material toward the dam. The horn further comprises first and second recesses located on opposite sides of a stem of the T-shaped flattening surface. The anvil cover overlies opposing portions of the anvil and comprises a T-shaped cutout. The T-shaped flattening surface of the horn fits in the T-shaped cutout of the anvil cover. The resulting zipper has slider end stops located at opposing ends.

Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

Abstract: A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.

Abstract: A solid polymer electrolyte fuel cell stack having a plurality of fuel cells, wherein at least one cell of the fuel cell stack has a resistance to corrosion that is greater than a significant portion of the other fuel cells of the stack. In one embodiment, the at least one fuel cell of the fuel cell stack that is more resistant to corrosion is one or both end cells of the stack. Also disclosed is a fuel cell system containing such a stack, as well as methods for reducing degradation of the same during operation.

Abstract: The present invention is a combination of in-situ etching with a grating mask pattern comprised only of semiconductor material, together with the fabrication of a protective layer beneath the semiconductor grating mask that protects the semiconductor material that readily oxidises. As such the present invention is based on a two-stage process. First the grating pattern is defined in a semiconductor material, wherein this pattern is called the semiconductor grating mask. The semiconductor grating mask sits on top of a layer of protective material, which in turn is on top of the semiconductor material that readily oxidises, wherein the protective layer prevents oxidation of the material below. The semiconductor structure is then moved to a reactor, where, in the second stage, the mask pattern is transferred into the underlying protective layer and the semiconductor material that readily oxidises, by in-situ etching.

Abstract: An apparatus for closing a slider-operated zipper on a moving filled package, comprising means for performing the following steps: conveying a package forward in a straight line; guiding a slider on a zippered portion of the package through a channel as the package moves forward; blocking forward movement of the slider at a predetermined position inside the channel as the package continues to move forward; and releasing the slider when the force being exerted by the slider in the forward direction reaches a level substantially equal to a predetermined threshold. This apparatus can be employed in association with a continuous band sealing apparatus. The means for blocking forward movement of the slider at a predetermined position inside the channel are a pair of spring-loaded plungers, e.g., ball plungers. If the slider end stop is weak, the slider will be pulled off the advancing package and will fall onto an ejection ramp.

Abstract: The present invention is a combination of in-situ etching using a grating mask that is formed in semiconductor material only and the subsequent overgrowth of additional semiconductor material to enclose the grating structure prior to exposure to the atmosphere and the contaminants therein. The present invention is based on a two-stage process. First the grating pattern is defined in a semiconductor material, which is the grating mask. This grating mask is created at a position above the material that is to ultimately contain the grating pattern. Upon the completion of the fabrication of the grating mask, the semiconductor structure is moved to a reactor, where in the second stage, the grating pattern defined by the grating mask is transferred into the underlying semiconductor layers by in-situ etching.

Abstract: In a solid polymer fuel cell series, various circumstances can result in the fuel cell being driven into voltage reversal. For instance, cell voltage reversal can occur if that cell receives an inadequate supply of fuel (for example, fuel starvation). In order to pass current during fuel starvation, reactions other than fuel oxidation may take place at the fuel cell anode, including water electrolysis and oxidation of anode components. The latter may result in significant degradation of the anode. Such fuel cells can be made more tolerant to cell reversal by promoting water electrolysis over anode component oxidation at the anode. This can be accomplished by incorporating a catalyst composition at the anode to promote the water electrolysis reaction, in addition to the typical anode electrocatalyst for promoting fuel oxidation.

Abstract: The present invention provides a self-aligned laser structure that can be fabricated on a p-substrate and provides a means for limiting the leakage current thereby improving the overall efficiency of the structure. The waveguide laser structure comprises a first series of layers deposited in sequence upon a p-InP, p-GaAs or p-GaN substrate or other form of p-substrate, wherein these layers form the p-clad layer. An active layer is subsequently deposited upon this first series of layers. A blocking layer of insulating or semi-insulating material is deposited upon the active layer, wherein this blocking layer has a trench formed therein, wherein this semi-insulating layer or layers are epitaxially deposited. The blocking layer provides a means for limiting current flow therethrough, thereby reducing leakage current. Upon the blocking layer are deposited a second series of layers completing the laser structure, wherein this second series of layers form the n-clad layer.

Abstract: Various systems, method and apparatuses are disclosed that include a pressure swing adsorption apparatus coupled to a fuel cell, wherein the fuel cell receives at least a portion of a product gas from the pressure swing adsorption and powers the pressure swing adsorption apparatus. Also disclosed is a portable gas separator that include a housing that houses a rotary pressure swing adsorption apparatus.