Patents by Inventor Daan Witters

Daan Witters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20250122560
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 17, 2025
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12227799
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: February 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • METHODS OF SEQUENCING CIRCULAR TEMPLATE POLYNUCLEOTIDES
    Publication number: 20250027151
    Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.
    Type: Application
    Filed: October 2, 2024
    Publication date: January 23, 2025
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Multiplexed targeted amplification of polynucleotides
    Patent number: 12188088
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: January 7, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Daan Witters, Tung Thanh Le
  • MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES
    Publication number: 20240425919
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.
    Type: Application
    Filed: June 15, 2023
    Publication date: December 26, 2024
    Inventors: Eli N. GLEZER, Daan WITTERS, Tung Thanh LE
  • NUCLEIC ACID CIRCULARIZATION AND AMPLIFICATION ON A SURFACE
    Publication number: 20240392369
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification and sequencing of nucleic acids.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 28, 2024
    Inventors: Daan Witters, Eli N. Glezer, Andrew King, Sabrina Shore, Ryan Shultzaberger
  • Methods of sequencing circular template polynucleotides
    Patent number: 12139759
    Abstract: Disclosed herein, inter alia, are methods of detecting or sequencing circular template polynucleotides on a solid support and/or in cells and tissues.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: November 12, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • SOLID PHASE NUCLEIC ACID AMPLIFICATION METHODS AND COMPOSITIONS
    Publication number: 20240368685
    Abstract: Disclosed herein, inter alia, are methods and compositions for amplifying and sequencing a plurality of template nucleic acids.
    Type: Application
    Filed: April 29, 2024
    Publication date: November 7, 2024
    Inventors: Eli N. Glezer, Daan Witters
  • Linked paired strand sequencing
    Patent number: 12123055
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 22, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Timothy Looney, Sabrina Shore, Ryan Shultzaberger, Daan Witters
  • MULTIPLEXED TARGETED AMPLIFICATION FOR MUTATION DETECTION
    Publication number: 20240342718
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification and sequencing of nucleic acid molecules including, for example, genetic mutations.
    Type: Application
    Filed: April 8, 2024
    Publication date: October 17, 2024
    Inventors: Eli N. Glezer, Daan Witters, Tung Thanh Le
  • Methods of amplifying circular polynucleotides in situ
    Patent number: 12110550
    Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.
    Type: Grant
    Filed: February 27, 2024
    Date of Patent: October 8, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • HIGH DENSITY SEQUENCING AND MULTIPLEXED PRIMING
    Publication number: 20240309359
    Abstract: Disclosed herein, inter alia, are methods and compositions for detecting a plurality of nucleic acids in a sample.
    Type: Application
    Filed: May 23, 2024
    Publication date: September 19, 2024
    Inventors: Eli N. GLEZER, Niek VAN WIETMARSCHEN, Daan WITTERS
  • Linked paired strand sequencing
    Patent number: 12077816
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: September 3, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Nucleic acid circularization and amplification on a surface
    Patent number: 12071665
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification of nucleic acid templates, including hybridizing a linear polynucleotide to an immobilized primer on a surface, circularizing the linear polynucleotide to form a circular polynucleotide, and extending the primer with a polymerase.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: August 27, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Andrew King, Sabrina Shore, Ryan Shultzaberger
  • METHODS OF SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
    Publication number: 20240271207
    Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.
    Type: Application
    Filed: February 27, 2024
    Publication date: August 15, 2024
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12060605
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: August 13, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • PURIFICATION AND DETECTION OF ANALYTES
    Publication number: 20240247247
    Abstract: A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.
    Type: Application
    Filed: September 20, 2023
    Publication date: July 25, 2024
    Inventors: Rustem ISMAGILOV, Erik JUE, Daan WITTERS
  • MULTIPLEXED TARGETED AMPLIFICATION OF POLYNUCLEOTIDES
    Publication number: 20240240251
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.
    Type: Application
    Filed: February 22, 2024
    Publication date: July 18, 2024
    Inventors: Eli N. Glezer, Daan Witters, Tung Thanh Le
  • NANOARRAYS AND METHODS OF USE THEREOF
    Publication number: 20240167089
    Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 23, 2024
    Inventors: Eli N. Glezer, Vahid Karimkhani, Shahed Kay, Mohammad Vatankhah Varnosfaderani, Daan Witters
  • MULTI-DIMENSIONAL POLYMER SCAFFOLDS FOR NUCLEIC ACID ANALYSES
    Publication number: 20240167087
    Abstract: Disclosed herein, inter alia, are compositions and methods for detecting polynucleotides within a three-dimensional matrix.
    Type: Application
    Filed: October 19, 2023
    Publication date: May 23, 2024
    Inventors: Eli N. Glezer, Daan Witters