Patents by Inventor Dai Wang
Dai Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122655Abstract: A method for accurately positioning a navigation target point includes: selecting a navigation reference with a fixed position, acquiring positions of the navigation reference and the navigation target point in a navigation coordinate system respectively, and calculating a position of the navigation target point relative to the navigation reference, so as to further obtain a position of the navigation target point in a coordinate system of the navigation reference. As long as the navigation reference does not move, the coordinate system of the navigation reference will not change during the entire navigation process, and spatial position coordinates of the navigation target point in the coordinate system of the navigation reference will not be interfered by the navigation coordinate system.Type: ApplicationFiled: August 10, 2022Publication date: April 18, 2024Inventors: Dai FEI, Shunli XU, Xiaopeng GONG, Yu WANG, Fengjie YAO
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Publication number: 20230399648Abstract: The disclosure describes methods for measuring the potency of anti-Respiratory Syncytial Virus (RSV) antibody against respiratory syncytial virus in a cell culture system using an RSV reporter virus. The disclosure also describes respiratory syncytial viruses that carry a reporter gene, and expression vectors for producing an infectious recombinant respiratory syncytial virus (RSV) that carry a reporter gene.Type: ApplicationFiled: November 8, 2021Publication date: December 14, 2023Applicant: MERCK SHARP & DOHME LLCInventors: Dai WANG, John P. BILELLO, Kevin B. GURNEY, Ping HAN, Xi HE, Dengyun SUN, Amy Hsu TOU
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Publication number: 20230390379Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.Type: ApplicationFiled: May 10, 2023Publication date: December 7, 2023Applicant: ModernaTX, Inc.Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
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Publication number: 20230357870Abstract: This application provides materials and methods related to replication competent, noninfectious coronavirus reporter replicons, such as for SARS-CoV-2, MERS, or SARS-CoV-1 comprising at least one coronavirus gene and at least one reporter gene. The application also provides methods for assaying candidate agents for inhibition of coronavirus viral replication.Type: ApplicationFiled: September 23, 2021Publication date: November 9, 2023Applicant: MERCK SHARP & DOHME LLCInventors: Xi HE, Shuo QUAN, Dai WANG, Min XU
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Publication number: 20230301573Abstract: The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use monitoring of a subset of symptoms and/or one or more biomarkers. The symptom severity can be assessed using the Positive and Negative Syndrome Scale (PANSS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.Type: ApplicationFiled: May 9, 2023Publication date: September 28, 2023Applicant: JANSSEN PHARMACEUTICA NVInventors: Dai Wang, Srihari Gopal, Vaibhav Narayan, Adam Savitz, Susan Baker
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Patent number: 11752206Abstract: Herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.Type: GrantFiled: March 15, 2018Date of Patent: September 12, 2023Assignee: ModernaTX, Inc.Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
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Patent number: 11723569Abstract: The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use monitoring of a subset of symptoms and/or one or more biomarkers. The symptom severity can be assessed using the Positive and Negative Syndrome Scale (PANSS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.Type: GrantFiled: November 21, 2017Date of Patent: August 15, 2023Assignee: JANSSEN PHARMACEUTICA NVInventors: Dai Wang, Srihari Gopal, Vaibhav Narayan, Adam Savitz, Susan Baker
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Publication number: 20230114180Abstract: The disclosure relates to respiratory syncytial vims (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.Type: ApplicationFiled: August 30, 2022Publication date: April 13, 2023Applicant: ModernaTX, Inc.Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
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Patent number: 11464848Abstract: The disclosure describes respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.Type: GrantFiled: March 15, 2018Date of Patent: October 11, 2022Assignee: ModernaTX, Inc.Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
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Publication number: 20220280636Abstract: The disclosure relates to HSV glycoprotein E antigenic peptide constructs and HSV protein vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. The present invention directed to immunogenic polypeptides of use for a vaccine against Herpes Simplex Vims (HSV). The polypeptides are glycoprotein E peptides that are mutated to reduce their binding to antibody Fc domain.Type: ApplicationFiled: July 14, 2020Publication date: September 8, 2022Applicant: Merck Sharp & Dohme Corp.Inventors: Arthur Fridman, Jennifer Dawn Galli, Dai Wang, Lan Zhang
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Patent number: 11230591Abstract: The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). The antigen binding proteins of the invention are useful as a prophylactic and/or therapeutic agent for preventing and/or treating CMV infections in a patient in need thereof. Also encompassed by the invention are pharmaceutical compositions comprising the antigen binding proteins of the invention and a pharmaceutically acceptable carrier. The invention further relates to methods of using the antigen binding proteins and pharmaceutical compositions of the invention for the prevention or treatment of CMV infection in patients in need thereof.Type: GrantFiled: April 18, 2017Date of Patent: January 25, 2022Assignees: Merck Sharp & Dohme Corp., The Board of Regents, The University of Texas SystemInventors: Tong-Ming Fu, Aimin Tang, Dai Wang, Zhiqiang An, Ningyan Zhang, Sha Ha
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Patent number: 11192105Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.Type: GrantFiled: March 23, 2020Date of Patent: December 7, 2021Assignee: Illumina, Inc.Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
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Patent number: 11160860Abstract: HSV glycoprotein B-VSV-G1 fusion proteins and variants thereof, HSV glycoprotein C antigenic peptide constructs and variants thereof, HSV immunogenic compositions and protein vaccines including the peptide constructs, and HSV DNA vaccines encoding the amino acid sequence of the peptide constructs, as well as methods of using the vaccines and compositions comprising the vaccines.Type: GrantFiled: April 25, 2018Date of Patent: November 2, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Dai Wang, Lan Zhang
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Patent number: 11129891Abstract: Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection.Type: GrantFiled: April 11, 2019Date of Patent: September 28, 2021Assignee: The Trustees of Princeton UniversityInventors: Thomas Shenk, Dai Wang
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Publication number: 20210270708Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Applicant: Illumina, Inc.Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
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Patent number: 11016008Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.Type: GrantFiled: December 13, 2017Date of Patent: May 25, 2021Assignee: ILLUMINA, INC.Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
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Publication number: 20210018527Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.Type: ApplicationFiled: October 2, 2020Publication date: January 21, 2021Inventors: Johanna L. Whitacre, Steven S. Phelps, Bradley Kent Drews, Debra Sue Bryan, II, Michael A. Niziolek, Joshua A. Darland, Umberto Ulmanella, Michael Dai Wang, Michelle L. Alvarez, Stephen Wayne Clark
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Patent number: 10830784Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.Type: GrantFiled: December 19, 2017Date of Patent: November 10, 2020Assignee: ILLUMINA, INC.Inventors: Johanna L. Whitacre, Steven S. Phelps, Bradley Kent Drews, Debra Sue Bryan, II, Michael A. Niziolek, Joshua A. Darland, Umberto Ulmanella, Michael Dai Wang, Michelle L. Alvarez, Stephen Wayne Clark
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Publication number: 20200230598Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel.Type: ApplicationFiled: March 23, 2020Publication date: July 23, 2020Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
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Publication number: 20200129615Abstract: The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.Type: ApplicationFiled: March 15, 2018Publication date: April 30, 2020Applicant: ModernaTX, Inc.Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang