Patents by Inventor Dai Wang

Dai Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11016008
    Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: May 25, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Publication number: 20210018527
    Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Inventors: Johanna L. Whitacre, Steven S. Phelps, Bradley Kent Drews, Debra Sue Bryan, II, Michael A. Niziolek, Joshua A. Darland, Umberto Ulmanella, Michael Dai Wang, Michelle L. Alvarez, Stephen Wayne Clark
  • Patent number: 10830784
    Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 10, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Johanna L. Whitacre, Steven S. Phelps, Bradley Kent Drews, Debra Sue Bryan, II, Michael A. Niziolek, Joshua A. Darland, Umberto Ulmanella, Michael Dai Wang, Michelle L. Alvarez, Stephen Wayne Clark
  • Publication number: 20200230598
    Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 23, 2020
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Publication number: 20200129608
    Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 30, 2020
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
  • Publication number: 20200129615
    Abstract: The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 30, 2020
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
  • Patent number: 10625260
    Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: April 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Publication number: 20200069792
    Abstract: The disclosure relates to HSV glycoprotein B and HSV glycoprotein C antigenic peptide constructs, HSV protein vaccines, and HSV DNA vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: April 25, 2018
    Publication date: March 5, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dai Wang, Lan Zhang
  • Publication number: 20200054737
    Abstract: The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: April 25, 2018
    Publication date: February 20, 2020
    Applicant: Modema TX, Inc.
    Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
  • Patent number: 10537892
    Abstract: Disclosed herein are devices and techniques for providing for enhanced fluid mixing in a sample vial. A plunger head may be removably housed inside of a cap that is attached to a container; the cap may have an opening allowing a shaft, e.g., a probe or sipper shaft, to be inserted into the cap and into the plunger head. The shaft may be used to push the plunger head free of the cap, and then to reciprocate the plunger head within the container to mix the content. Withdrawal of the shaft may then cause the plunger head to disengage from the shaft and remain in the container.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: James Christopher Blake, Umberto Ulmanella, Bradley Kent Drews, Michael Dai Wang, Stephen Wayne Clark, Michael Adalbert Niziolek
  • Publication number: 20190358317
    Abstract: Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection.
    Type: Application
    Filed: April 11, 2019
    Publication date: November 28, 2019
    Inventors: Thomas Shenk, Dai Wang
  • Publication number: 20190345245
    Abstract: A method for treating depression, anhedonia, or fatigue in a subject comprises administering an agent that blocks binding of IL-23 to IL-23 receptor, for example, an anti-IL-23 antibody or an antigen-binding fragment thereof that may comprise a heavy chain variable region and a light chain variable region of SEQ ID NO:106 and SEQ ID NO:116, respectively.
    Type: Application
    Filed: May 10, 2019
    Publication date: November 14, 2019
    Inventors: Wayne Drevets, Dai Wang, Gayle Wittenberg
  • Patent number: 10300130
    Abstract: Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 28, 2019
    Assignee: The Trustees of Princeton University
    Inventors: Thomas Shenk, Dai Wang
  • Publication number: 20190106481
    Abstract: A supercritical extractor system may include extractor chambers coupled to a supercritical fluid pump and configured to receive a matrix for an extraction process and a supercritical fluid from the supercritical fluid pump, and evaporator chambers coupled to the extractor chambers and configured to output an extractant from the matrix. Each evaporator chamber may include a body defining a cavity, a cone within the cavity, and arms coupled between an inner surface of the body and the cone. The supercritical extractor system may include a condenser coupled between the evaporator chambers and the supercritical fluid reservoir, and a controller coupled to the supercritical fluid pump, the extractor chambers, and the evaporator chambers and configured to monitor a characteristic during the extraction process.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 11, 2019
    Applicants: Merck Sharp & Dohme Corp., The Board of Regents, The University of Texas System
    Inventors: Tong-Ming Fu, Aimin Tang, Dai Wang, Zhiqiang An, Ningyan Zhang, Sha Ha
  • Publication number: 20180271970
    Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: October 21, 2016
    Publication date: September 27, 2018
    Applicant: ModernaTX, INC.
    Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
  • Publication number: 20180185840
    Abstract: Disclosed herein are devices and techniques for providing for enhanced fluid mixing in a sample vial. A plunger head may be removably housed inside of a cap that is attached to a container; the cap may have an opening allowing a shaft, e.g., a probe or sipper shaft, to be inserted into the cap and into the plunger head. The shaft may be used to push the plunger head free of the cap, and then to reciprocate the plunger head within the container to mix the content. Withdrawal of the shaft may then cause the plunger head to disengage from the shaft and remain in the container.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 5, 2018
    Inventors: James Christopher Blake, Umberto Ulmanella, Bradley Kent Drews, Michael Dai Wang, Stephen Wayne Clark, Michael Adalbert Niziolek
  • Publication number: 20180188141
    Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 5, 2018
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Publication number: 20180185842
    Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 5, 2018
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Publication number: 20180188279
    Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 5, 2018
    Inventors: Johanna L. Whitacre, Steven S. Phelps, Bradley Kent Drews, Debra Sue Bryan, II, Michael A. Niziolek, Joshua A. Darland, Umberto Ulmanella, Michael Dai Wang, Michelle L. Alvarez, Stephen Wayne Clark
  • Publication number: 20180140242
    Abstract: The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use monitoring of a subset of symptoms and/or one or more biomarkers. The symptom severity can be assessed using the Positive and Negative Syndrome Scale (PANSS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 24, 2018
    Inventors: Dai Wang, Srihari Gopal, Vaibhav Narayan, Adam Savitz, Susan Baker