Abstract: A torque device employs a cylindrical housing surrounding a guidewire to provide concentric loading of the guidewire along a central axis of the housing attachable at any point along a length of the guidewire. Improved torsion of the guidewire is obtained by clamping the guidewire so that it runs along the center axis of the housing offering intuitive rotational handling (torque) of the guidewire along the torque axis.

Abstract: The present invention provides a guide wire and catheter disk holder that carries coiled guide wires and catheters with easy insertion of coiled guide wires and catheters through a side cutout on the holder allowing the user’s hand to extend through the disk. The coiled guide wires and catheters are inserted substantially along a plane of the disk thus encouraging uncoiling and expanding of the wires and catheters into a longitudinal channel of the disk. The secured wire can be pulled out of the disk by holding and pulling the entire coiled wire, or by simply pulling the end of the wire while the rest of the wire is still secured inside the holder. Optionally, a spool may be inserted into the disk holder in order to wind up uncoiled wire and catheter within the disk holder.

Abstract: The present technology provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel. The compositions may further include a polythiol agent. Such compositions are injectable due to their shear-thinning properties, yet stay in place, undergo in situ crosslinking, and provide safe, simple and efficacious endovascular embolization. Methods of making and using such compositions are also provided.

Abstract: A foreign substance removing device includes a tubular member and a retriever configured to be expandable to and contractible from a predetermined shape. The retriever includes main wires disposed to be centered around a tube axis of the tubular member, and sub wires each connecting adjacent ones of the main wires to each other. Each of the main wires is configured to curve when the retriever is expanded such that a space having a predetermined size is provided by the main wires. Each of the sub wires is configured to be foldable at at least one point between the adjacent ones of the main wires. When the retriever is expanded, the folding points of the sub wires are positioned inside the space such that the sub wires do not protrude out of the main wires.

Abstract: A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

Abstract: A filler delivery device is configured to place a filler inside a bulge occurring in a body lumen. The filler delivery device includes a frame member configured to be expandable and compressible, and a tubular member through which a catheter for injecting the filler into the bulge is insertable. The tubular member is provided such that, when the frame member is in an expanded state, an open end of the tubular member is directed in a direction intersecting an extending direction of the body lumen. The filler material includes a base gel having flowability with which the filler material flows inside the catheter, and shape retainability with which the filler material stays inside the bulge after being injected from the catheter into the bulge, and a solidification promoting substance that promotes solidification of blood inside the bulge.

Abstract: A medical device is configured to treat a body cavity. The medical device includes a tubular sheath portion, a foreign substance capturing catheter configured to be movable inside the sheath portion, the foreign substance capturing catheter having a capturing portion configured to capture a foreign substance inside the body cavity, a treatment catheter configured to be movable inside the foreign substance capturing catheter, the treatment catheter having a treatment portion configured to treat the body cavity. The medical device is configured to be inserted into the body cavity in a state in which the treatment catheter is set inside the foreign substance capturing catheter and the foreign substance capturing catheter is set inside the sheath portion.

Abstract: Provided is a method for manufacturing an administrable aqueous solution to a living body, the administrable aqueous solution having a function of supplying sufficient oxygen to peripheral cells, causing less damage and injury of cells under a hypoxic or anaerobic stimulation, and continuously exhibiting a sufficiently high and stable effect to protect cells. The administrable aqueous solution to a living body according to the present invention contains oxygen nanobubbles having a mean particle size of 30 nm or less and a density of 1016 bubbles per ml, preferably a mean particle size of 1 to 10 nm and a density 1017 bubbles or more per ml, respectively, as determined by a measurement with a cryo-transmission electron microscope by an ice-embedding method.

Abstract: An infarction preventive device includes a cylindrical filter, a tube configured to hold a base end portion of the filter and place the filter in a blood vessel, and a recovery member configured to recover the filter placed in the blood vessel into the tube.

Abstract: A foreign substance removing device includes a tubular member and a retriever configured to be expandable to and contractible from a predetermined shape. The retriever includes main wires disposed to be centered around a tube axis of the tubular member, and sub wires each connecting adjacent ones of the main wires to each other. Each of the main wires is configured to curve when the retriever is expanded such that a space having a predetermined size is provided by the main wires. Each of the sub wires is configured to be foldable at at least one point between the adjacent ones of the main wires. When the retriever is expanded, the folding points of the sub wires are positioned inside the space such that the sub wires do not protrude out of the main wires.

Abstract: Provided are an administrable aqueous solution to a living body and a method for manufacturing the same, the administrable aqueous solution having a function of supplying sufficient oxygen to peripheral cells, causing less damage and injury of cells under a hypoxic or anaerobic stimulation, and continuously exhibiting a sufficiently high and stable effect to protect cells. The administrable aqueous solution to a living body according to the present invention contains oxygen nanobubbles having a mean particle size of 30 nm or less and a density of 1016 bubbles per ml, preferably a mean particle size of 1 to 10 nm and a density 1017 bubbles or more per ml, respectively, as determined by a measurement with a cryo-transmission electron microscope by an ice-embedding method.

Abstract: A filler delivery device is configured to place a filler inside a bulge occurring in a body lumen. The filler delivery device includes a frame member configured to be expandable and compressible, and a tubular member through which a catheter for injecting the filler into the bulge is insertable. The tubular member is provided such that, when the frame member is in an expanded state, an open end of the tubular member is directed in a direction intersecting an extending direction of the body lumen. The filler material includes a base gel having flowability with which the filler material flows inside the catheter, and shape retainability with which the filler material stays inside the bulge after being injected from the catheter into the bulge, and a solidification promoting substance that promotes solidification of blood inside the bulge.

Abstract: A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

Abstract: An infarction prevention device has a filter to be placed inside a blood vessel. The filter includes a connection portion having a base end to be connected to a placing member configured to place the filter inside the blood vessel, and a cylindrical body portion connected to a front end of the connection portion. At least one of the connection portion and the cylindrical body portion includes a capturing portion configured to capture a foreign substance included in blood inside the blood vessel such that the at least one of the connection portion and the body portion controls a flow of the foreign substance.

Abstract: A medical device is configured to treat a body cavity. The medical device includes a tubular sheath portion, a foreign substance capturing catheter configured to be movable inside the sheath portion, the foreign substance capturing catheter having a capturing portion configured to capture a foreign substance inside the body cavity, a treatment catheter configured to be movable inside the foreign substance capturing catheter, the treatment catheter having a treatment portion configured to treat the body cavity. The medical device is configured to be inserted into the body cavity in a state in which the treatment catheter is set inside the foreign substance capturing catheter and the foreign substance capturing catheter is set inside the sheath portion.

Abstract: A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

Abstract: The present invention is directed to a method for treating aneurysms in vascular tissue. The method includes administering a bisphosphonate compound to a subject in an amount which is effective against the formation or progression of aneurysm, or which is effective to induce regression of an established aneurysm. In alternative methods, an anti-RANKL neutralizing antibody is administered to the subject to achieve analogous anti-aneurysm effect. The methods of particular advantage in the treatment of subjects having an abdominal aortic aneurysm, a relatively common, and life-threatening, condition.

Abstract: The present invention is directed to a method for treating aneurysms in vascular tissue. The method includes administering a bisphosphonate compound to a subject in an amount which is effective against the formation or progression of aneurysm, or which is effective to induce regression of an established aneurysm. In alternative methods, an anti-RANKL neutralizing antibody is administered to the subject to achieve analogous anti-aneurysm effect. The methods of particular advantage in the treatment of subjects having an abdominal aortic aneurysm, a relatively common, and life-threatening, condition.