Abstract: A display control device includes a driving plan setter and a notification controller. The driving plan setter sets the driving plan of a vehicle equipped with a display from a departure point to a destination. The notification controller controls the display that displays the driving plan. When the driving plan setter changes the driving plan, the notification controller causes the display to display a changed driving plan, by controlling the display. The notification controller includes an emphasis display enabler that causes the display to display the changed driving plan in an emphasized manner, when the driving plan is changed by the driving plan setter.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: An information processing device includes: an ECU; a management ECU that provides the ECU with a virtual storage including a first storage area and a second storage area, one of which stores a first program to be executed by the ECU on start-up; an update controller that obtains, from an external device, a second program that is an update to the first program, and causes a remaining one of the first storage area and the second storage area to store the second program obtained; and a switching unit that switches a program to be executed by the ECU on start-up from the first program to the second program stored in the remaining one of the storage areas, after the second program is stored in the remaining one of the storage areas.

Abstract: The power supply apparatus includes a power transmission apparatus configured to transmit power to a power reception apparatus of the vehicle by non-contact and a processor configured to control the power transmission apparatus, detect a pickup/dropoff operation at the vehicle when power is being supplied by non-contact from the power supply apparatus to the vehicle, and detect a number of surrounding vehicles being supplied with power by non-contact in a predetermined range at surroundings of the power supply apparatus. The processor is configured to decrease power transmitted from the power transmission apparatus to the power reception apparatus when detecting a pickup/dropoff operation, and determine an amount of decrease of the transmitted power based on the number of surrounding vehicles.

Abstract: A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.

Abstract: An inspection device and an inspection method are provided. The inspection device includes: a main body portion, configured to be held by an inspector; a camera portion, disposed on the main body portion and configured to capture an inspected portion of a vehicle; and a guiding portion, configured to guide a camera direction of the camera portion to the inspector, so that an image obtained through the camera portion becomes a prescribed image suitable for inspection.

Abstract: An information processing device includes a storage in which a first program is stored and an update controller that updates the first program to a second program by use of data obtained from an external device. For each of a plurality of first partial areas obtained by dividing a first storage area storing the first program, the update controller copies a first partial program that is a part of the first program and that is stored in the first storage area to a second storage area and then successively updates the first partial program to a second partial program that is a part of the second program by use of the data. The data is difference information indicating a difference between the first program and the second program. The second storage area has a storage capacity smaller than a storage capacity of the first storage area.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Provided herein are RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof, and lipids. RNA molecules and compositions including them are useful for inducing immune responses.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: Lipid formulations that encapsulate messenger RNA (mRNA) are provided herein. The mRNA can be used to express CFTR protein in vitro or in vivo. The lipid formulations can be administered via inhalation to treat cystic fibrosis.

Abstract: A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.

Abstract: A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. Also provided are processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein. The RNA molecules can be included in a composition used for preventing, treating, or ameliorating at least one symptom of a disease or condition in a subject in need thereof.

Abstract: An information processing device includes a storage in which a first program is stored and an update controller that updates the first program to a second program by use of data obtained from an external device. For each of a plurality of first partial areas obtained by dividing a first storage area storing the first program, the update controller copies a first partial program that is a part of the first program and that is stored in the first storage area to a second storage area and then successively updates the first partial program to a second partial program that is a part of the second program by use of the data. The data is difference information indicating a difference between the first program and the second program. The second storage area has a storage capacity smaller than a storage capacity of the first storage area.

Abstract: An information processing device includes: an ECU; a management ECU that provides the ECU with a virtual storage including a first storage area and a second storage area, one of which stores a first program to be executed by the ECU on start-up; an update controller that obtains, from an external device, a second program that is an update to the first program, and causes a remaining one of the first storage area and the second storage area to store the second program obtained; and a switching unit that switches a program to be executed by the ECU on start-up from the first program to the second program stored in the remaining one of the storage areas, after the second program is stored in the remaining one of the storage areas.

Abstract: Nucleotides encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein are provided herein. Also describe are mRNA constructs that can be used to express CFTR protein in vitro or in vivo. The mRNA constructs can be formulated in a lipid formulation and administered via inhalation to treat cystic fibrosis.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.