Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: A program update system updating programs comprising: a first control device executing a program stored in the primary storage area thereof; a second control device executing a program stored in the primary storage area thereof; a program storage temporarily storing an acquired program; a program acquirer preferentially acquiring and storing into the program storage a first program to be stored in the first control device, and acquiring and storing into the program storage a second program to be stored in the second control device; and an update unit storing the first program stored in the program storage into the primary storage area of the first control device, storing the second program stored in the program storage into the primary storage area of the second control device, and switching the primary storage area and the secondary storage area of the first control device.

Abstract: A program update system updating programs comprising: a first control device executing a program stored in the primary storage area thereof; a second control device executing a program stored in the primary storage area thereof; a program storage temporarily storing an acquired program; a program acquirer preferentially acquiring and storing into the program storage a first program to be stored in the first control device, and acquiring and storing into the program storage a second program to be stored in the second control device; and an update unit storing the first program stored in the program storage into the primary storage area of the first control device, storing the second program stored in the program storage into the primary storage area of the second control device, and switching the primary storage area and the secondary storage area of the first control device.

Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5? UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.

Abstract: An in-vehicle display system is provided with first display unit, second display unit, vehicle information acquisition unit, and CPU. When a display operation for outputting at least a portion of first content to second display unit with the first content being output to first display unit is performed, CPU selects either of first display unit and second display unit with which to associate an authority to operate the output of at least one of first display unit and second display unit according to at least one signal from among a plurality of signals indicating a type of the first content, an attribute of first display unit, an attribute of second display unit, vehicle information, and a detail of the display operation.

Abstract: An in-vehicle display system is provided with first display unit, second display unit, vehicle information acquisition unit, and CPU. When a display operation for outputting at least a portion of first content to second display unit with the first content being output to first display unit is performed, CPU selects either of first display unit and second display unit with which to associate an authority to operate the output of at least one of first display unit and second display unit according to at least one signal from among a plurality of signals indicating a type of the first content, an attribute of first display unit, an attribute of second display unit, vehicle information, and a detail of the display operation.

Abstract: A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. This invention also provides processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein.