Patents by Inventor Daisy Joe

Daisy Joe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    Patent number: 6828343
    Abstract: This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prod rugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: December 7, 2004
    Assignee: Pfizer, Inc.
    Inventor: Daisy Joe Du Bois
  • 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists
    Publication number: 20040014775
    Abstract: This invention relates to certain pyrimidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Application
    Filed: July 1, 2003
    Publication date: January 22, 2004
    Inventors: Daisy Joe Du Bois, Long Mao, Daniel Harry Rogers, John Patrick Williams
  • Piperidine CCR-3 receptor antagonists
    Publication number: 20030229121
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: December 11, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    Publication number: 20030195361
    Abstract: This invention relates to compounds of Formula I 1
    Type: Application
    Filed: February 14, 2003
    Publication date: October 16, 2003
    Applicant: Pfizer Inc.
    Inventor: Daisy Joe Du Bois
  • Piperazine CCR-3 receptor antagonists
    Publication number: 20030176441
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 29, 2002
    Publication date: September 18, 2003
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • CCR-3 receptor antagonists (I)
    Publication number: 20030153578
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: November 27, 2002
    Publication date: August 14, 2003
    Inventors: Daisy Joe Du Bois, Beihan Wang
  • CCR-3 receptor antagonists
    Publication number: 20030119885
    Abstract: The invention provides compounds of Formula (I): 1
    Type: Application
    Filed: September 12, 2002
    Publication date: June 26, 2003
    Inventor: Daisy Joe Du Bois
  • Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    Patent number: 6576653
    Abstract: This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: June 10, 2003
    Assignee: Pfizer Inc.
    Inventor: Daisy Joe Du Bois
  • Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    Publication number: 20020183369
    Abstract: This invention relates to compounds of Formula I 1
    Type: Application
    Filed: April 5, 2002
    Publication date: December 5, 2002
    Inventor: Daisy Joe Du Bois
  • Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    Patent number: 6399601
    Abstract: This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: June 4, 2002
    Assignee: Pfizer Inc.
    Inventor: Daisy Joe Du Bois
  • FK-506 type macrolide intermediate
    Patent number: 5235066
    Abstract: An intermediate, useful in the conversion of FK-506 to FK-525 and analogous 23-membered ring macrolides, of the structure: ##STR1##
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: August 10, 1993
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Daisy Joe, Ralph P. Volante, Ichiro Shinkai
  • Synthetic process for FK-506 type macrolide intermediates
    Patent number: 5164525
    Abstract: A process for the conversion of FK-506 (I,R=allyl;1) to FK-525 (XV) and analogous 23-membered ring macrolides differing in the C.1-N.7 segment of the molecule (e.g. XVI) and is also applicable to the analogs FK-523 (XVII) and FK-520 (XVIII). The overall process consists of three stages: (a) initial degradation of the primary macrolide to an acyclic fragment containing a selectively protected C.10-C.34 framework with a protected aldehyde function at C.10 and a free hydroxyl function at C.26, (b) reacylation of the C.26 hydroxyl function with an appropriately N-protected alpha-amino acid moiety, and (c) reintroduction of the C.8 and C.9 carbons followed by regeneration of the FK-macrolide system.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: November 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Ralph P. Volante, Daisy Joe, Ichiro Shinkai