Patents by Inventor Dale Ando

Dale Ando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inactivating a glucocorticoid receptor gene in an isolated cell
    Patent number: 11884930
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 30, 2024
    Assignees: Sangamo Biosciences, Inc., City of Hope
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Method for the treatment of mucopolysaccharidosis type I
    Patent number: 11857641
    Abstract: Described herein are methods and compositions for treating MPS I (Hurler/Hurler-Scheie/Scheie Syndrome) by administering to the subject a composition comprising a iduronidase (IDUA) polynucleotide. In one aspect, provided is a method of reducing, delaying and/or eliminating one or more of the need for additional treatment procedures, the onset, progression and/or severity of symptoms in a subject with MPS I, by administering to the subject a composition comprising a iduronidase (IDUA) polynucleotide.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: January 2, 2024
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Dale Ando, Cheryl Wong Po Foo, Sagar A. Vaidya, Shelley Q. Wang
  • Methods and compositions for gene inactivation
    Patent number: 11648267
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: May 16, 2023
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • METHOD OF INACTIVATING A GLUCOCORTICOID RECEPTOR GENE IN AN ISOLATED CELL
    Publication number: 20210102222
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 8, 2021
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Isolated human cell with an inactivated glucocorticoid receptor gene
    Patent number: 10907175
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 2, 2021
    Assignees: Sangamo Therapeutics, Inc., City of Hope
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • METHODS AND COMPOSITIONS FOR INCREASING RNA ACTIVITY IN A CELL
    Publication number: 20200318140
    Abstract: Disclosed herein are methods and compositions for increasing RNA activity in a cell.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 8, 2020
    Inventors: Siyuan Tan, Dale Ando, Andreas Reik, Linhong Li, Madhusudan V. Peshwa, Haiyan Jiang
  • METHOD FOR THE TREATMENT OF MUCOPOLYSACCHARIDOSIS TYPE I
    Publication number: 20200246486
    Abstract: Described herein are methods and compositions for treating MPS I (Hurler) disease.
    Type: Application
    Filed: August 7, 2019
    Publication date: August 6, 2020
    Inventors: Dale Ando, Cheryl Wong Po Foo, Sagar A. Vaidya, Shelley Q. Wang
  • METHOD FOR THE TREATMENT OF MUCOPOLYSACCHARIDOSIS TYPE II
    Publication number: 20200063160
    Abstract: Described herein are methods and compositions for treating MPSII (Hunter) disease.
    Type: Application
    Filed: August 7, 2019
    Publication date: February 27, 2020
    Inventors: Dale Ando, Cheryl Wong Po Foo, Sagar A. Vaidya, Shelley Q. Wang
  • METHODS AND COMPOSITIONS FOR GENE INACTIVATION
    Publication number: 20180312826
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Application
    Filed: July 3, 2018
    Publication date: November 1, 2018
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • METHODS AND COMPOSITIONS FOR INCREASING RNA ACTIVITY IN A CELL
    Publication number: 20170137845
    Abstract: Disclosed herein are methods and compositions for increasing RNA activity in a cell.
    Type: Application
    Filed: November 9, 2016
    Publication date: May 18, 2017
    Inventors: Siyuan Tan, Dale Ando, Andreas Reik, Lihong Li, Madhusudan V. Peshwa, Haiyan Jiang
  • METHODS AND COMPOSITIONS FOR GENE INACTIVATION
    Publication number: 20160326505
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Application
    Filed: July 27, 2016
    Publication date: November 10, 2016
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • Methods and compositions for gene inactivation
    Patent number: 9434776
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: September 6, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • METHOD OF INACTIVATING A GLUCOCORTICOID RECEPTOR GENE IN AN ISOLATED CELL
    Publication number: 20160076056
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Application
    Filed: November 20, 2015
    Publication date: March 17, 2016
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Method of inactivating a glucocorticoid receptor gene in an isolated cell
    Patent number: 9217026
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: December 22, 2015
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • METHODS AND COMPOSITIONS FOR GENE INACTIVATION
    Publication number: 20140127811
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 8, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • Methods and compositions for gene inactivation
    Patent number: 8569253
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: October 29, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • Methods and compositions for gene inactivation
    Patent number: 8524221
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: September 3, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Yann Jouvenot, Gary Ka Leong Lee
  • Methods And Compositions For Gene Inactivation
    Publication number: 20120309091
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Application
    Filed: May 9, 2011
    Publication date: December 6, 2012
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee
  • Methods and Compositions for Gene Inactivation
    Publication number: 20120308528
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Application
    Filed: May 5, 2011
    Publication date: December 6, 2012
    Inventors: Dale Ando, Michael C. Holmes, Yann Jouvenot, Gary Ka Leong Lee
  • Methods and compositions for gene inactivation
    Patent number: 7951925
    Abstract: Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: May 31, 2011
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Dale Ando, Michael C. Holmes, Gary Ka Leong Lee