Patents by Inventor Dale G. Swan
Dale G. Swan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11246963Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.Type: GrantFiled: May 16, 2014Date of Patent: February 15, 2022Assignee: Surmodics, Inc.Inventors: Joram Slager, Dale G. Swan, Darin DuMez, Joseph Ventura, Shannon Wadman, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Patent number: 10745573Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: GrantFiled: April 8, 2019Date of Patent: August 18, 2020Assignee: Surmodics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Publication number: 20190367748Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: ApplicationFiled: April 8, 2019Publication date: December 5, 2019Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 10253193Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: GrantFiled: May 31, 2018Date of Patent: April 9, 2019Assignee: Surmodics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Publication number: 20180273773Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: ApplicationFiled: May 31, 2018Publication date: September 27, 2018Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 9994721Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: GrantFiled: October 3, 2016Date of Patent: June 12, 2018Assignee: Surmodics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 9629945Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.Type: GrantFiled: December 12, 2013Date of Patent: April 25, 2017Assignee: SURMODICS, INC.Inventors: Aleksey V. Kurdyumov, Dale G. Swan, Nathan A. Lockwood, Bruce M. Jelle
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Publication number: 20170022375Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: ApplicationFiled: October 3, 2016Publication date: January 26, 2017Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 9487663Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: GrantFiled: November 14, 2014Date of Patent: November 8, 2016Assignee: Surmodics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Publication number: 20150166801Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: ApplicationFiled: November 14, 2014Publication date: June 18, 2015Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 8889760Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: GrantFiled: March 29, 2011Date of Patent: November 18, 2014Assignee: SurModics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Publication number: 20140336571Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.Type: ApplicationFiled: May 16, 2014Publication date: November 13, 2014Applicant: SurModics, Inc.Inventors: Joram Slager, Dale G. Swan, Darin DuMez, Joseph Ventura, Shannon Wadman, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Patent number: 8802121Abstract: Silane-functionalized hydrophobic ?(1?4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic ?(1?4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.Type: GrantFiled: June 2, 2010Date of Patent: August 12, 2014Assignee: Surmodics, Inc.Inventors: Aleksey V. Kurdyumov, Nathan A. Lockwood, Joram Slager, Dale G. Swan, Robert Hergenrother
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Publication number: 20140162083Abstract: The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.Type: ApplicationFiled: December 12, 2013Publication date: June 12, 2014Applicant: SurModics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan, Nathan A. Lockwood, Bruce M. Jelle
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Patent number: 8709489Abstract: The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.Type: GrantFiled: September 30, 2010Date of Patent: April 29, 2014Assignee: SurModics, Inc.Inventors: Joram Slager, Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 8586731Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.Type: GrantFiled: June 11, 2010Date of Patent: November 19, 2013Assignee: Surmodics, Inc.Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
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Patent number: 8512736Abstract: Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.Type: GrantFiled: November 11, 2005Date of Patent: August 20, 2013Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
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Publication number: 20130143056Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Other embodiments are also included herein.Type: ApplicationFiled: June 7, 2012Publication date: June 6, 2013Applicant: SURMODICS, INC.Inventors: Dale G. Swan, Aleksey V. Kurdyumov, Bruce M. Jelle
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Patent number: 8241656Abstract: Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.Type: GrantFiled: November 11, 2005Date of Patent: August 14, 2012Assignee: Surmodics, IncInventors: Stephen J. Chudzik, Dale G. Swan, Michael J. Burkstrand
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Patent number: 8241655Abstract: Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.Type: GrantFiled: May 12, 2005Date of Patent: August 14, 2012Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand