Patents by Inventor Dale G. Swan
Dale G. Swan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7585499Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: GrantFiled: April 10, 2003Date of Patent: September 8, 2009Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Publication number: 20090042742Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: ApplicationFiled: September 14, 2007Publication date: February 12, 2009Applicant: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Patent number: 7348055Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.Type: GrantFiled: December 21, 2001Date of Patent: March 25, 2008Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
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Patent number: 7309593Abstract: The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.Type: GrantFiled: October 1, 2003Date of Patent: December 18, 2007Assignee: SurModics, Inc.Inventors: Ronald F. Ofstead, Melvin J. Swanson, Dale G. Swan
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Patent number: 7300756Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface.Type: GrantFiled: May 12, 2004Date of Patent: November 27, 2007Assignee: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
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Patent number: 7138541Abstract: Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.Type: GrantFiled: June 20, 2005Date of Patent: November 21, 2006Assignee: SurModics, Inc.Inventor: Dale G. Swan
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Patent number: 7087658Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: GrantFiled: December 23, 2003Date of Patent: August 8, 2006Assignee: SurModics, Inc.Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Ralph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Patent number: 6924390Abstract: Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.Type: GrantFiled: July 14, 2003Date of Patent: August 2, 2005Assignee: SurModics, Inc.Inventor: Dale G. Swan
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Publication number: 20040209305Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: May 12, 2004Publication date: October 21, 2004Applicant: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
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Publication number: 20040202774Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
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Publication number: 20040203075Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic &bgr; cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.Type: ApplicationFiled: April 10, 2003Publication date: October 14, 2004Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Dale G. Swan
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Publication number: 20040137164Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: ApplicationFiled: December 23, 2003Publication date: July 15, 2004Applicant: SURMODICS, INC.Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Ralph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Patent number: 6762019Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: GrantFiled: March 9, 2000Date of Patent: July 13, 2004Assignee: SurModics, Inc.Inventors: Dale G. Swan, Melvin J. Swanson
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Publication number: 20040044404Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.Type: ApplicationFiled: August 30, 2002Publication date: March 4, 2004Inventors: Sean M. Stucke, Kimberly K.M. Lindsoe, Ralph A. Chappa, Dale G. Swan
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Publication number: 20040030159Abstract: Compounds useful as surface coating agents, including compounds of the formula: 1Type: ApplicationFiled: July 14, 2003Publication date: February 12, 2004Inventor: Dale G. Swan
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Patent number: 6669994Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.Type: GrantFiled: April 23, 2001Date of Patent: December 30, 2003Assignee: SurModics, Inc.Inventors: Dale G. Swan, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Ralph A. Chappa, Sean M. Stucke, Peter H. Duquette
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Publication number: 20030165613Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.Type: ApplicationFiled: December 21, 2001Publication date: September 4, 2003Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
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Publication number: 20030148308Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: July 9, 2002Publication date: August 7, 2003Applicant: SurModics, Inc.Inventors: Ralph A. Chappa, Sheau-Ping Hu, Dale G. Swan, Melvin J. Swanson, Patrick E. Guire
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Patent number: 6603040Abstract: Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.Type: GrantFiled: June 25, 2001Date of Patent: August 5, 2003Assignee: SurModics, Inc.Inventor: Dale G. Swan
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Publication number: 20030113792Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: ApplicationFiled: March 9, 2000Publication date: June 19, 2003Inventors: Dale G. Swan, Melvin J. Swanson