Abstract: The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type Cav1.3 (e.g., a dihydropyridine such as isradipine), and a second compound that is monoamine oxidase inhibitor and/or is a nitric oxide synthase inhibitor (e.g., rasagiline or derivative thereof).

Abstract: An apparatus for delivering alternate user input between an alternate input device and an output device, the output device configured to receive input from a conventional input device, the output device not configured to receive input from the alternate input device, the apparatus including an input interconversion processor that receives the alternate user input from the alternate input device, a processing pipeline that converts the alternate user input to a conventional user input of a type normally received by the output device from the conventional input device, and an output port that transmits the conventional user input.

Abstract: The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s).

Abstract: A heat press includes a handle portion and a curved heat plate. That handle portion may be configured to be grasped by a user, and the curved heat (i.e., having a curved engagement surface) may be configured to engage a heat-activated design implement to transfer a design of the heat-activated design implement to a curved surface of a workpiece. Also disclosed herein, according to various embodiments, is a heat press stand having a curved floor and a hat form for supporting a workpiece (e.g., a hat) during a heat-activated design transfer using the heat press. Associated methods are also disclosed herein.

Abstract: A valve assembly for a dispenser. The valve assembly includes a valve body. The valve body includes a first hoop member, a second hoop member, and a transition portion defined by the joining of the first hoop member and the second hoop member. The first hoop member includes a first hoop outer portion positioned, a first hoop inner portion, a first hoop upper surface, and a first hoop lower surface. The second hoop member includes a second hoop outer portion, a second hoop inner portion, a second hoop upper surface, and a second hoop lower surface. The second hoop inner portion extends about the longitudinal axis defining a passageway. The passageway comprises a first passageway opening, a second passageway opening opposite the first passageway opening, and a passageway surface extending from the first passageway opening to the second passageway opening.

Abstract: Systems and methods are provided for performing simulated phishing attacks using social engineering indicators. One or more failure indicators can be configured in a phishing email template, and each failure indicator can be assigned a description about that failure indicator through use of a markup tag. The phishing email template containing the markup tags corresponding to the failure indicators can be stored and can be used to generate a simulated phishing email in which the one or more markup tags are removed.

Abstract: A home occupancy status and information system may be used to track information about human and animal occupants within a structure, and provide information to first responders in the event of an emergency. A rescue beacon may be positioned near an entrance to a home, and when an audible alarm or alarm signal is detected by the beacon it will provide visual alerts and/or audible alerts to attract the attention of a first responder, and will provide information on occupants in the home, such as a number of pets, a number of humans, and other information. A rescue device may also be carried by each pet or other occupant in the house, which may be activated by a wireless signal from a rescue beacon, or by a detected alarm audio/signal. When activated, the rescue device will provide audible and/or visual alerts to aid first responders in locating the occupant.

Abstract: A dividable dough sheet piece gives consumers enhanced flexibility in creating food items from pre-made sheeted dough. The dividable dough sheet piece is cut from a dough sheet, with the dividable dough sheet piece having a perimeter and including a plurality of interconnected, sub-pieces defined within the perimeter. Each sub-piece is defined by one or more lines of structural weakness that provide predetermined breaking points. The dividable dough sheet piece can be used as a whole or can be divided into the sub-pieces for alternative use.

Abstract: A knife case and associated components and methods. The knife case includes a case body and a plurality of holders. For example, the case may be configured to hold a plurality of blade components configured to be interchangeably mounted on a handle. The knife may be an electric knife, and the case can include a battery dock for holding a spare battery.

Abstract: A vehicle air register assembly includes a housing defining a cavity. An upstream portion of the cavity is disposed proximate to an inlet and a downstream portion of the cavity is disposed proximate to an outlet. Vertical vanes are disposed within the upstream portion. The vertical vanes direct air in a horizontal direction. A horizontal vane assembly is disposed within the downstream portion. The horizontal vane assembly directs the air in a vertical direction. The horizontal vane assembly includes at least one horizontal vane including a driver portion rotatably coupled to the housing proximate to the outlet and a follower portion coupled to the housing proximate to the upstream portion. The follower portion is rotatably coupled to the driver portion.

Abstract: A device includes a multiple analyte sensor, a transimpedance amplifier, and a differential amplifier. The multiple analyte sensor includes a first working electrode, a second working electrode, a counter electrode, and a reference electrode. Each of the first working electrode and the second working electrode is configured to receive a signal indicative of a presence of a respective analyte. The counter electrode is a sum of the received signal of each of the first working electrode and the second working electrode. The transimpedance amplifier is configured to receive a first signal of the received signals from the first working electrode and a second signal of the received signals from the second working electrode. The transimpedance amplifier converts the received first signal and the received second signal to an output including a variable bias offset. The differential amplifier is configured to subtract the variable bias offset from the output.

Abstract: A paint sprayer includes an end bell, a motor connected to the end bell, a pump drive connected to the end bell, a pair of protrusions attached to an extending from the end bell such that each protrusion is cantilevered from the end bell, and a pump assembly comprising a pair of mounting holes and containing a piston. The pair of mounting holes is adapted to receive and slide onto the pair of protrusions to mount the pump assembly on the end bell as well as slide off of the pair of protrusions to remove the pump assembly from the end bell. The pump drive is configured to covert rotational motion output by the motor to reciprocal motion. The pump assembly is configured to pump paint when reciprocated by the pump drive while mounted on the end bell.

Abstract: A system for retracting a foil of a watercraft in the event of an impact has a strut extending from a watercraft, the strut has a pivot at one end that connects the strut to the watercraft and allows the strut to articulate around the pivot, a foil attached at a second end of the strut, wherein the foil has sufficient surface area configured to generate positive lift when the watercraft is traveling over water; and a retraction system including a mechanical fuse connected to the strut, the mechanical fuse holds the strut stationary and is subject to forces from the strut when the strut travels through water, the retraction system allows retraction of the strut around the pivot when the strut experiences a force greater than a predetermined limit, and the foil is configured to articulate on the strut to maintain positive lift orientation as the strut is retracting.

Abstract: A method of analysing and tracking machine systems has the steps of sensing operational data from equipment, the operational data comprising at least location, time, and one or more operational condition data related to the equipment; analysing the operational data to identify data patterns; logging the data patterns as events in a database; comparing the events to a database of predetermined patterns to classify each data pattern as a known event or an unknown event; updating the database to include a new data pattern related to any unknown events; and alerting a user to further classify the unknown events manually.

Abstract: A kiosk includes a work surface and a storage container coupled to the work surface. A hardware-control device is coupled to the kiosk to allow for remote troubleshooting of hardware at the kiosk. The storage container includes a plurality of storage lockers that can store and dispense hardware if troubleshooting the device at the kiosk is unsuccessful.

Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.

Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

Abstract: A method to determine, by a computing system, a trust score for a network entity in a computer network, the trust score for the network entity indicating a level of trust in the network entity; and modifying, by the computing system, a traffic pattern of the computer network based on the trust score for the network entity.