Patents by Inventor Dan Barouch

Dan Barouch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potent zika virus-specific and cross-neutralizing monoclonal antibodies to zika and dengue viruses following ZIKV infection or vaccination
    Patent number: 11884718
    Abstract: The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: January 30, 2024
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Beth Israeli Deaconess Medical Center, Inc., The Government Of The United States As Represented By The Secretary Of The Army
    Inventors: Shelly Krebs, Gina Donofrio, Vincent Dussupt, Kayvon Modjarrad, Dan Barouch, Richard G. Jarman, III, Nelson L. Michael, Gordon Joyce, Rajeshwer Singh Sankhala, Kathryn Elaine Stephenson
  • Compositions and Methods for Inducing Protective Immunity Against Human Immunodeficiency Virus Infection
    Publication number: 20220096622
    Abstract: Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 31, 2022
    Inventors: Dan BAROUCH, Johanna SCHUITEMAKER, Maria Grazia PAU, Danielle VAN MANEN, Frank TOMAKA, Jennifer Anne HENDRIKS
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 11229696
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: January 25, 2022
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • Compositions and methods for inducing protective immunity against human immunodeficiency virus infection
    Patent number: 11207400
    Abstract: Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: December 28, 2021
    Assignees: Janssen Vaccines & Prevention B.V., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan Barouch, Johanna Schuitemaker, Maria Grazia Pau, Danielle Van Manen, Frank Tomaka, Jennifer Anne Hendriks
  • Potent Zika Virus-Specific and Cross-Neutralizing Monoclonal Antibodies to Zika and Dengue Viruses Following Zikv Infection or Vaccination
    Publication number: 20210238262
    Abstract: The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 5, 2021
    Applicants: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Beth Israel Deaconess Medical Center, Inc., The Government of the United States as Represented by the Secretary of the Army
    Inventors: Shelly Krebs, Gina Donofrio, Vincent Dussupt, Kayvon Modjarrad, Dan Barouch, Richard G. Jarman, III, Nelson L. Michael, Gordon Joyce
  • METHOD OF PROVIDING SAFE ADMINISTRATION OF ADENOVIRAL VECTORS ENCODING A ZIKA VIRUS ANTIGEN
    Publication number: 20210113682
    Abstract: Provided are methods for generating an immune response against a Zika virus in a human subject in need thereof. The methods comprise administering to the subject a pharmaceutical composition comprising adenoviral vectors encoding a Zika virus antigen and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 11, 2020
    Publication date: April 22, 2021
    Inventors: Dan BAROUCH, Macaya Julie DOUOGUIH, Gaston Rafael PICCHIO
  • Method of providing safe administration of adenoviral vectors encoding a zika virus antigen
    Patent number: 10864263
    Abstract: Provided are methods for generating an immune response against a Zika virus in a human subject in need thereof. The methods comprise administering to the subject a pharmaceutical composition comprising adenoviral vectors encoding a Zika virus antigen and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 15, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Beth Israel Deaconess Medical Center. Inc.
    Inventors: Dan Barouch, Macaya Julie Douoguih, Gaston Rafael Picchio
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20200323976
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 10653770
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: May 19, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • COMPOSITIONS AND METHODS FOR INDUCING PROTECTIVE IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20200030437
    Abstract: Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Inventors: Dan BAROUCH, Johanna SCHUITEMAKER, Maria Grazia PAU, Danielle VAN MANEN, Frank TOMAKA, Jennifer Anne HENDRIKS
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20200023056
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 23, 2020
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
    Patent number: 10525123
    Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: January 7, 2020
    Assignees: Janssen Vaccines & Prevention B.V., Beth Israel Deaconess Medical Center, Inc., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., The Government of The United States, as represented by The Secretary Of The Army
    Inventors: Frank Tomaka, Maria Grazia Pau, Johanna Schuitemaker, Dan Barouch, Jintanat Ananworanich, Merlin Robb, Nelson L. Michael, Jerome Kim
  • Methods for inducing protective immunity against human immunodeficiency virus infection
    Patent number: 10471137
    Abstract: Compositions, vaccines and methods for inducing protective immunity against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 12, 2019
    Assignees: Janssen Vaccines & Prevention B.V., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan Barouch, Johanna Schuitemaker, Maria Grazia Pau, Danielle Van Manen, Frank Tomaka, Jennifer Anne Hendriks
  • METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDERGOING ANTIRETROVIRAL TREATMENT
    Publication number: 20190247491
    Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 15, 2019
    Inventors: Frank TOMAKA, Maria Grazia PAU, Johanna SCHUITEMAKER, Dan BAROUCH, Jintanat ANANWORANICH, Merlin ROBB, Nelson L. MICHAEL, Jerome KIM
  • Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
    Patent number: 10307477
    Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 4, 2019
    Assignees: Janssen Vaccines & Prevention B.V., The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Beth Israel Deaconess Medical Center, Inc., The United States of America, as represented by The Secretary Of The Army
    Inventors: Frank Tomaka, Maria Grazia Pau, Johanna Schuitemaker, Dan Barouch, Jintanat Ananworanich, Merlin Robb, Nelson L. Michael, Jerome Kim
  • METHOD OF PROVIDING SAFE ADMINISTRATION OF ADENOVIRAL VECTORS ENCODING A ZIKA VIRUS ANTIGEN
    Publication number: 20190151434
    Abstract: Provided are methods for generating an immune response against a Zika virus in a human subject in need thereof. The methods comprise administering to the subject a pharmaceutical composition comprising adenoviral vectors encoding a Zika virus antigen and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 23, 2019
    Inventors: Dan BAROUCH, Macaya Julie DOUOGUIH, Gaston Rafael PICCHIO
  • METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDERGOING ANTIRETROVIRAL TREATMENT
    Publication number: 20190083620
    Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and either a Modified Vaccinia Ankara virus (MVA) vector booster vaccine or adenovirus booster vaccine in combination with isolated HIV envelope polypeptides.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Maria Grazia PAU, Frank TOMAKA, Daniel John STIEH, Michal SARNECKI, Dan BAROUCH, Boris JUELG
  • METHODS FOR SAFE INDUCTION OF CROSS-CLADE IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN
    Publication number: 20190022212
    Abstract: Methods for inducing safe and effective immune response against multiple clades of Human Immunodeficiency Virus (HIV) infection in human subjects are described. The methods involve heterologous vaccine combinations of adenovirus serotype 26 expression vectors expressing at least three mosaic HIV antigens with at least one isolated HIV gp140 protein.
    Type: Application
    Filed: July 20, 2018
    Publication date: January 24, 2019
    Inventors: Dan BAROUCH, Johanna SCHUITEMAKER, Maria Grazia PAU, Danielle VAN MANEN, Frank TOMAKA, Jennifer Anne HENDRIKS
  • Methods and compositions for inducing protective immunity against human immunodeficiency virus infection
    Patent number: 10137191
    Abstract: Compositions, vaccines and methods for inducing protective immunity against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: November 27, 2018
    Assignees: Janssen Vaccines & Prevention B.V., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan Barouch, Johanna Schuitemaker, Maria Grazia Pau, Danielle Van Manen, Frank Tomaka, Jennifer Anne Hendriks
  • METHODS FOR INDUCING PROTECTIVE IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20180250385
    Abstract: Compositions, vaccines and methods for inducing protective immunity against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: Dan BAROUCH, Johanna SCHUITEMAKER, Maria Grazia PAU, Danielle VAN MANEN, Frank TOMAKA, Jennifer Anne HENDRIKS