Patents by Inventor Dan Barouch

Dan Barouch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDERGOING ANTIRETROVIRAL TREATMENT
    Publication number: 20180064803
    Abstract: Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: Frank TOMAKA, Maria Grazia PAU, Johanna SCHUITEMAKER, Dan BAROUCH, Jintanat ANANWORANICH, Merlin ROBB, Nelson L. MICHAEL, Jerome KIM
  • Replicating recombinant adenovirus vectors, compositions, and methods of use thereof
    Patent number: 9750801
    Abstract: Replicating recombinant adenovirus vectors derived from human adenovirus serotype 26 or human adenovirus serotype 35 are described. The replicating recombinant adenovirus vectors have attenuated replicative capacity as compared to that of the corresponding wild-type adenovirus. They can be used for stable expression of heterologous genes in vivo. Also described are compositions and methods of using these recombinant adenovirus vectors to induce an immune response in a subject, and vaccinate a subject against an immunogenic human immunodeficiency virus (HIV) infection.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: September 5, 2017
    Assignees: Janssen Vaccines & Prevention B.V., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan Barouch, Peter Abbink
  • Viruses associated with immunodeficiency and enteropathy and methods using same
    Patent number: 9683268
    Abstract: The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 20, 2017
    Assignees: Beth Israel Deaconess, Washington University
    Inventors: Dan Barouch, Herbert W Virgin, David Wang, Guoyan Zhao, Larissa Thackray, Scott Handley, Rachel Presti
  • METHODS AND COMPOSITIONS FOR INDUCING PROTECTIVE IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20160089432
    Abstract: Compositions, vaccines and methods for inducing protective immunity against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more viral expression vectors and an isolated antigenic polypeptide induced strong protective immunity against infections by one or multiple clades of HIV.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 31, 2016
    Inventors: Dan BAROUCH, Johanna SCHUITEMAKER, Maria GRAZIA PAU, Danielle VAN MANEN, Frank TOMAKA, Jennifer Anne HENDRIKS
  • VIRUSES ASSOCIATED WITH IMMUNODEFICIENCY AND ENTEROPATHY AND METHODS USING SAME
    Publication number: 20150284814
    Abstract: The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
    Type: Application
    Filed: September 19, 2013
    Publication date: October 8, 2015
    Applicant: Beth Israel Deaconess
    Inventors: Dan Barouch, Herbert W. Virgin, David Wang, Guoyan Zhao, Larissa Thackray, Scott Handley, Rachel Presti
  • REPLICATING RECOMBINANT ADENOVIRUS VECTORS, COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20150246112
    Abstract: Replicating recombinant adenovirus vectors derived from human adenovirus serotype 26 or human adenovirus serotype 35 are described. The replicating recombinant adenovirus vectors have attenuated replicative capacity as compared to that of the corresponding wild-type adenovirus. They can be used for stable expression of heterologous genes in vivo. Also described are compositions and methods of using these recombinant adenovirus vectors to induce an immune response in a subject, and vaccinate a subject against an immunogenic human immunodeficiency virus (HIV) infection.
    Type: Application
    Filed: February 26, 2015
    Publication date: September 3, 2015
    Inventors: Dan BAROUCH, Peter ABBINK
  • Adjuvants Of Immune Response
    Publication number: 20070298051
    Abstract: The present invention features methods to substantially increase the immunogenicity of a vaccine, preferably a DNA vaccine, and involves providing a mammal with a vaccine regimen, which includes an immunogen and Flt3L in combination with MIP-1? or MIP-3?. The methods of the present invention can be used for the prevention and treatment of various pathological states, including for example, cancer, microbial infections, autoimmune diseases, tissue rejection, and allergic reactions.
    Type: Application
    Filed: November 19, 2004
    Publication date: December 27, 2007
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Dan Barouch, Shawn Sumida, Norman Letvin