Abstract: Provided is a Coxsackievirus A6 (CVA6) strain CVA6-KM-J33 and use thereof, and belongs to the technical field of biomedicine. The present invention provides a CVA6 strain CVA6-KM-J33, which belongs to a CVA6 virus. In the present invention, the strain CVA6-KM-J33 is susceptible to KMB17 cells and can achieve a relatively high titer. The strain has strong virulence, high pathogenicity and lethality to suckling mice, and desirable immunogenicity, and is a highly effective virus strain for CVA6 vaccine development. This strain can be used for immunogenicity evaluation or protective evaluation of CVA6 vaccine to improve the accuracy and reproducibility of vaccine immunogenicity evaluation. This strain can also be used to prepare animal models of Coxsackievirus (CV) infection, and exhibits desirable application prospects.

Abstract: A large-scale in-situ dewatering treatment method and device for lake sludge are provided. The large-scale in-situ dewatering treatment method for lake sludge includes: step S1, sludge excavation: excavating sludge from a lake and transporting the sludge to a detention pond; step S2, in-situ detention: filtering the sludge in the detention pond to obtain filtered sludge; step S3, dewatering: transporting the filtered sludge to a dewatering workshop and performing deep dewatering on the filtered sludge to obtain mud blocks and wastewater; and step S4, environmental protection treatment: using the mud blocks to build an island near a dredging platform in the lake. The large-scale in-situ dewatering treatment method for lake sludge not only solves the problems of difficulty in selecting a temporary sludge disposal site and high capital investment costs in a traditional lake dredging operation, but also reduces the transportation cost of transporting sludge to a land.

Abstract: An enterovirus multi-antigen epitope fusion protein, a gene, a vaccine and a preparation method thereof are provided, relating to the field of vaccine preparation technologies. The amino acid sequence of the enterovirus multi-antigen epitope fusion protein is shown in SEQ ID NO: 4. The vaccine is prepared by adopting the preparation method of a genetically engineered protein vaccine, and the prepared vaccine has stronger specificity. After protein purification, there are fewer impure proteins and more specific antigen proteins, thus improving the effectiveness and safety of the combined vaccine.

Abstract: A multi-task learning method comprises: determining participating nodes; performing clustering to the participating nodes and determining several clusters; determining a global model for the clusters according to the several clusters and by means of the federated learning within the cluster; determining a cluster key feature set of any one of the clusters according to the cluster model and by means of calculation with the SHAP framework; determining a global model according to the cluster key feature set; and training the global model according to the any one of the clusters, and determining the cluster model of the any one of the clusters, wherein a plurality of the clusters are used for achieving multi-task learning. In the present application, by clustering, the participating nodes having similar device performance and data distribution are collected into the same group, and the participating nodes within the same cluster are trained together.

Abstract: Provided is a risk assessment method for power transmission line windage yaw flashover. The method includes determining the influence factors of power transmission line windage yaw flashover and setting risk assessment indexes according to the influence factors (S101); generating the standard cloud of the risk assessment indexes according to the incident occurrence probabilities and the consequence levels of the risk assessment indexes (S103); scoring the influence factors according to the risk assessment indexes and generating the risk cloud of the risk assessment indexes according to scoring results (S105); and performing a two-dimensional similarity calculation on the risk cloud and the standard cloud to obtain two-dimensional similarity between the risk cloud and the standard cloud and determining the risk level of the power transmission line windage yaw flashover according to the two-dimensional similarity (S107).

Abstract: Provided are a method for preparing genetically engineered erythrocytes carrying an anti-PD-1 single chain antibody, and genetically engineered erythrocytes carrying the anti-PD-1 single chain antibody. The preparation method comprises the following steps: constructing a desired fragment sequence in a lentiviral expression vector, lentivirally packaging the vector of the desired sequence to obtain a high-titer lentiviral concentrate; isolating Lin?CD34? cells from peripheral blood mononuclear cells and enriching the Lin?CD34? cells; inducing the Lin?CD34? cells to differentiate into erythroid and performing proliferation thereon; using the lentiviral concentrate to infect the Lin?CD34? cells; and obtaining mature anti-PD-1 scFv erythrocytes via erythrocyte denucleation. The present genetically engineered erythrocytes carrying the anti-PD-1 single chain antibody can perform the targeted delivery of an anti-PD-1 single-chain antibody to tumor tissues.

Abstract: Pharmaceutical compositions comprising nitroxoline lysinate, a preparation method therefor and a use thereof. The pharmaceutical compositions comprise a first layer and a second layer. The first layer comprises, based on the total weight of the first layer, 40%-70% of active pharmaceutical ingredient, 10%-30% of filler, 5%-12% of disintegrant, 0.5%-2% of lubricant, 0.1%-1.5% of glidant and 10%-20% of alkaline substance. The second layer comprises, based on the total weight of the second layer, 40%-70% of active pharmaceutical ingredient, 10%-30% of filler, 10%-35% of sustained-release material, 0.1%-2% of lubricant and 0.1%-2% of glidant. The active pharmaceutical ingredient is selected from one or more of nitroxoline lysinate, nitroxoline lysinate crystalline form and nitroxoline lysinate solvate. The pharmaceutical compositions can achieve the purpose of burst release at an early stage and sustained and slow release at a later stage.

Abstract: Disclosed is a process of manufacturing a thickened angle ring. The process includes the steps of: soaking wet paper into deionized water for 1 hour; beating bonding surfaces of the two pieces of wet paper into fuzzed and rough surfaces; placing a heat resisting polyester film and a nylon net on a mold, and placing one fuzzed wet paper on the mold in contact with the nylon net on smooth side thereof; placing the other wet paper in contact with the fuzzed surface of the previous wet paper on fuzzed side thereof, and beating until the wet paper fits the mold; placing a further heat resisting polyester film and a further nylon net on the two pieces of wet paper for pressing.

Abstract: The present invention discloses a cyclopenta[c]chromene compound and a preparation method thereof. A chalcone compound as a reactant, A cationic rare earth metal compound Ln(CH3CN)9]3+[(AlCl4)3]3?.CH3CN as a catalyst, and 2-naphthalenethiol as an accelerator, react in an organic solvent to prepare the cyclopenta[c]-chromene compound. Ln represents a positive trivalent rare earth metal ion, which is selected from the group consisting of La, Nd, Sm, Gd, and Yb. The starting materials are easy obtained, the reaction process is simple, and the yield of the target product is high, up to 85%.

Abstract: Examples of the present disclosure provide a method for setting up a route path, a device and a computer-readable storage medium. The method may include: establishing a neighbor list; wherein, the neighbor list comprises neighbor nodes of the node and position information of the neighbor nodes; in response to receiving a routing request (RREQ) message from a previous hop node, recording a source Internet Protocol (IP) address of a source node contained in the RREQ message as a destination IP address in a routing table established in the node; recording the previous hop node as a next hop node corresponding to the destination IP address in the routing table; selecting a pre-determined number of nodes from the neighbor list as next hop nodes of the RREQ message according to the position information of the neighbor nodes; and sending the RREQ message to the next hop nodes.

Abstract: The present invention discloses a method for preparing a cyclopenta[c]chromene compound. A cationic rare earth compound [Ln(CH)3CN)9]3+[(AlCl4)3]3?.CH3CN is used as a catalyst, and p-methyl thiophenol is used as an accelerator for a catalytic reaction of a chalcone compound so as to prepare a product; and Ln, contained in the catalyst, represents a positive trivalent rare earth metal ion and is selected from one of La, Nd, Sm, Gd and Yb. According to the method, the starting materials are easy to obtain, the reaction process is simple, the catalyst usage is low, the catalyst is universally applicable to various substituted 2-hydroxy chalcones, and the obtained cyclopenta[c]chromene compound has not been reported. The catalyst synthesis method is simple and easy to obtain, and the yield of the target product is high.

Abstract: A pixel driving circuit, an organic light emitting display panel and a pixel driving method. The pixel driving circuit includes: a switching sub-circuit, a driving sub-circuit, a storage capacitor and a charge eliminating sub-circuit; the charge eliminating sub-circuit has a control terminal connected to a first scanning signal line, and other terminals connected to the first terminal of the driving sub-circuit, a cathode of the organic light emitting element (OLED) and a reference voltage terminal respectively, and can enable a potential between the anode and the cathode of the organic light emitting element to be reversed under control of the first scanning signal line.

Abstract: Examples of the present disclosure provide a method for setting up a route path, a device and a computer-readable storage medium. The method may include: establishing a neighbor list; wherein, the neighbor list comprises neighbor nodes of the node and position information of the neighbor nodes; in response to receiving a routing request (RREQ) message from a previous hop node, recording a source Internet Protocol (IP) address of a source node contained in the RREQ message as a destination IP address in a routing table established in the node; recording the previous hop node as a next hop node corresponding to the destination IP address in the routing table; selecting a pre-determined number of nodes from the neighbor list as next hop nodes of the RREQ message according to the position information of the neighbor nodes; and sending the RREQ message to the next hop nodes.

Abstract: Disclosed is a process of manufacturing a thickened angle ring. The process includes the steps of: soaking wet paper into deionized water for 1 hour; beating bonding surfaces of the two pieces of wet paper into fuzzed and rough surfaces; placing a heat resisting polyester film and a nylon net on a mold, and placing one fuzzed wet paper on the mold in contact with the nylon net on smooth side thereof; placing the other wet paper in contact with the fuzzed surface of the previous wet paper on fuzzed side thereof, and beating until the wet paper fits the mold; placing a further heat resisting polyester film and a further nylon net on the two pieces of wet paper for pressing.

Abstract: A pixel driving circuit, an organic light emitting display panel and a pixel driving method. The pixel driving circuit includes: a switching sub-circuit, a driving sub-circuit, a storage capacitor and a charge eliminating sub-circuit; the charge eliminating sub-circuit has a control terminal connected to a first scanning signal line, and other terminals connected to the first terminal of the driving sub-circuit, a cathode of the organic light emitting element (OLED) and a reference voltage terminal respectively, and can enable a potential between the anode and the cathode of the organic light emitting element to be reversed under control of the first scanning signal line.

Abstract: The present invention discloses a method for preparing a cyclopenta[c]chromene compound. A cationic rare earth compound [Ln(CH)3CN)9]3+[(AlCl4)3]3?.CH3CN is used as a catalyst, and p-methyl thiophenol is used as an accelerator for a catalytic reaction of a chalcone compound so as to prepare a product; and Ln, contained in the catalyst, represents a positive trivalent rare earth metal ion and is selected from one of La, Nd, Sm, Gd and Yb. According to the method, the starting materials are easy to obtain, the reaction process is simple, the catalyst usage is low, the catalyst is universally applicable to various substituted 2-hydroxy chalcones, and the obtained cyclopenta[c]chromene compound has not been reported. The catalyst synthesis method is simple and easy to obtain, and the yield of the target product is high.

Abstract: The present invention discloses a cyclopenta[c]chromene compound and a preparation method thereof. A chalcone compound as a reactant, A cationic rare earth metal compound Ln(CH3CN)9]3+[(AlCl4)3]3?.CH3CN as a catalyst, and 2-naphthalenethiol as an accelerator, react in an organic solvent to prepare the cyclopenta[c]-chromene compound. Ln represents a positive trivalent rare earth metal ion, which is selected from the group consisting of La, Nd, Sm, Gd, and Yb. The starting materials are easy obtained, the reaction process is simple, and the yield of the target product is high, up to 85%.

Abstract: Disclosed are Lactobacillus rhamnosus strain 753 and uses thereof, a silage additive and silage. Lactobacillus rhamnosus strain 753 is deposited in China General Microbiological Culture Collection Center with an accession number of CGMCC 18233. Lactobacillus rhamnosus strain 753 can improve the quality of silage in a high-temperature and high-humidity region, and the silage processed by Lactobacillus rhamnosus strain 753 has good stability and low pH, low aflatoxin B1 content and less dry matter loss. In addition, secondary fermentation can be avoided in the silage processed by Lactobacillus rhamnosus strain 753 when a silo or bale for silage is opened.

Abstract: A digitizer, a signal transmission device, a digitizer device and control methods thereof are provided. The digitizer includes an operating panel and a first processor. The operating panel is provided with multiple photoelectric sensors. The multiple photoelectric sensors receive an external optical signal, convert the optical signal into an electric signal, and transmit the electric signal to the first processor. The first processor is configured to determine, in accordance with the electric signal, a location where the optical signal is received.