Abstract: The present disclosure provides two specific T cell receptors targeting a G12V or G12C mutant epitope of a KRAS gene, and an anti-tumor use thereof. Each of the two T cell receptors consists of an ? peptide chain and a ? peptide chain. Further provided are an antigen binding fragment of the T cell receptors, a nucleic acid encoding the T cell receptors or an antigen binding fragment thereof, a vector comprising the nucleic acid, and a host cell comprising the vector. Further provided is a method for preparing a specific T cell receptor for a KRAS G12V mutation or an antigen-binding fragment thereof. The specific T cell receptor and antigen-binding fragment thereof can be used as an immune activator to stimulate an immune response of an organism, thereby generating an effect against tumors and other diseases.

Abstract: A display substrate and a display device are disclosed, the display substrate has a plurality of sub-pixels and includes a base substrate, a driving circuit layer, a light-emitting device layer, and a black matrix layer, the driving circuit layer includes a first signal line and a second signal line arranged parallel to each other and arranged periodically, the black matrix layer includes a plurality of first light-transmitting openings and a plurality of second light-transmitting openings, the plurality of second light-transmitting openings are respectively arranged between the plurality of first light-transmitting openings and orthographic projections of the plurality of second light-transmitting openings (1132) on the base substrate (-1-04)-are respectively between an orthographic projection of one first signal line {&4-on the base substrate 0-04-)-and an orthographic projection of one second signal line (82)-closest to the one first signal line (84)-on the base substrate

Abstract: A system for controlling the amount of a liquid carbon source released to a constructed wetland, includes: a carbon source pool, a carbon source pipe, a peristaltic pump, a programmable logic controller (PLC), a computer, a first flow meter, a first chemical oxygen demand (COD) sensor, a first total nitrogen (TN) sensor, a second TN sensor, a second COD sensor, an inlet pipe, and an outlet pipe. The first flow meter, the first COD sensor, and the TN sensor are disposed on the inlet pipe; the second COD sensor and the second TN sensor are disposed on the outlet pipe; the inlet pipe and the outlet pipe are connected to the constructed wetland; the carbon source pipe is connected to the carbon source pool via the peristaltic pump; the computer, the peristaltic pump, the first flow meter, and all sensors are connected to the PLC controller.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: The disclosure discloses a method for enhancing denitrification of sewage with a low carbon-to-nitrogen ratio by using an electrode biocarrier, and relates to the field of sewage treatment. The disclosure uses a conductive material as a microbial carrier and a potentiostat to induce a micro-electric field for directional acclimation and enrichment of electroactive denitrification microorganisms, and realizes a high-efficiency denitrification of the sewage with a low carbon-to-nitrogen ratio. The disclosure aims to provide a technical method for solving the problem of deep denitrification of municipal sewage with a low carbon-to-nitrogen ratio.

Abstract: T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments thereof, and fusion proteins thereof useful for binding to and inhibiting B7-H4. Also provided are nucleic acid molecules encoding the antibodies, antigen-binding fragments thereof, and fusion proteins thereof disclosed herein and therapeutic compositions thereof. Disclosed are further methods of using the disclosed antibodies, antigen-binding fragments thereof, and fusion proteins thereof for the treatment of disease.

Abstract: Provided are a whole bacteria capsule, a preparation method therefor and a use thereof. The preparation method comprises the steps of: (1) screening fecal bacteria donors using high-throughput sequencing; (2) collecting feces of the fecal bacteria donors screened in step (1), and preparing a fecal bacterial liquid; and (3) mixing the fecal bacterial liquid prepared in step (2) with a freeze-drying protective agent, cooling, freezing and vacuum-drying the mixture, and loading the freeze-dried feces bacteria powder obtained into a capsule shell to obtain the whole bacteria capsule. By screening the fecal bacteria donors using high-throughput sequencing, fecal bacteria donors can be quickly screened for different fecal bacteria receptors, and the whole bacteria capsule prepared can accurately match with the fecal bacteria receptors.

Abstract: A method and system for modeling, simulating, and optimizing a FinFET device based on self-heating effect are provided. The method includes: building and electrically simulating a FinFET device model based on general data through simulation software; thermally simulating the FinFET device model to obtain a thermal parameter; modifying a simulated ambient temperature according to the thermal parameter and modifying the electrical characteristic parameter of the FinFET device model in an environment where a FinFET device is affected by self-heating; and finally building the FinFET device model based on self-heating effect. The method and system for modeling, simulating, and optimizing the FinFET device based on self-heating effect in disclosure provides lowered errors of device simulation, improved modeling precision, and enhanced accuracy of reliability analyses when being compared with conventional modeling without considering the self-heating effect.

Abstract: The present disclosure provides a testing method and a testing device. The testing method includes: configuring one or more testing parameters for a to-be-tested object, and performing at least two testing processes to obtain a testing value of each performance index for each testing process, each of the at least two testing processes being used to test different performance index of the to-be-tested object or to test different performance indices of the to-be-tested object; and generating a testing result of the to-be-tested object in accordance with the testing value of each performance index for each testing process. According to the present disclosure, it is able to perform the multi-dimensional test, thereby to meet the requirement on the performance indices in different scenarios, improve the testing efficiency, and increase the reliability of the testing result for true performance of a terminal.

Abstract: Vaporizer and/or electronic cigarette chargers useful for the recharging of rechargeable vaporizer or electronic cigarette power supplies such as batteries, compatible vaporizers and/or electronic cigarettes, their components, charging contacts, methods of their use and kits containing such chargers are disclosed.

Abstract: A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (µm); providing cylindrical focusing optics corrected for spherical aberration; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: For a distributed and decentralized blockchain system using state function driven consensus protocol, the identity of the network node that is selected for building the next block is publicly known since it is determined by the blockchain state function at the current blockchain state. An administrator proxy contract protocol is proposed and implemented to protect the identity of the actual builder of the next block until the block is built and synchronized across the blockchain network. A notion of blockchain clock and a method to construct such a clock are introduced to replace computer system clock as a synchronized measure of blockchain state progression. A secured form of the blockchain state function is constructed based on the administrator proxy contract protocol and is used to against any blockchain state manipulation attempts by an adversary.

Abstract: Magic cube speaker with charging stand, charging block, and methods for controlling the same, comprising a magic cube module having a liner with a cavity inside and splicing blocks installed on surface of the liner, a speaker inside the cavity, a charging interface, and a button mounted to the splicing block. The splicing block comprises sound passages formed by a sound inlet port, a sound outlet port, and a middle section between the sound inlet and outlet ports. A first sound transmission channel is formed by the cavity inside the liner, the sound transmission holes, the sound inlet port, the hollow space inside the splicing block, and the sound outlet port, and a second sound transmission channel is formed by the cavity inside the liner, the sound transmission holes, the sound inlet port, the hollow space inside the splicing block, and the plurality of the micro holes.

Abstract: A method of forming a high temperature sensor includes preparing a substrate having a surface from an electrically insulative material having a first coefficient of thermal expansion (CTE), preparing an electrical conductor from a metal material having a second CTE that is different from the first CTE, and creating an interface between the electrical conductor and the substrate with a CTE blending medium that is provided between the substrate and the electrical conductor. The CTE blending medium accommodates differing thermal expansion rates of the substrate and the electrical conductor at temperatures of at least 700° C.

Abstract: The present disclosure relates to a memory test system and a memory test method. The memory test system comprises: a plurality of test devices, a host computer, and driving modules. Each of the test devices is provided with a test interface used for connecting a memory to be tested. The host computer is respectively connected to the plurality of test devices and configured to control the test devices to test the memory to be tested. The driving modules are connected to the test devices and configured to output, to the test devices, driving signals used for driving the test devices to perform data interaction with the host computer.

Abstract: A method of forming a high temperature sensor includes preparing a substrate having a surface from an electrically insulative material having a first coefficient of thermal expansion (CTE), preparing an electrical conductor from a metal material having a second CTE that is different from the first CTE, and creating an interface between the electrical conductor and the substrate with a CTE blending medium that is provided between the substrate and the electrical conductor. The CTE blending medium accommodates differing thermal expansion rates of the substrate and the electrical conductor at temperatures of at least 700° C.

Abstract: The present disclosure provides a method and device for managing information, relating to the field of terminal information management, and solving the problem of cumbersome operation of information management. The method includes displaying, at a mobile terminal comprising a microprocessor, a network connection, and a display, a calendar interface, and when an operating instruction indicating extended display input by a user is detected on the calendar interface, displaying, at the mobile terminal, associated information corresponding to a date at a preset display position of the calendar interface.

Abstract: The present disclosure provides a memory test method, a storage medium and a computer device. The memory test method comprises: obtaining a target test pattern that needs to be written into a plurality of chip interfaces, the plurality of chip interfaces being connected to a plurality of physical interfaces in a one-to-one correspondence; determining second information of the chip interfaces corresponding to first information of the physical interfaces, and using the first information and the second information as corresponding connection information; remapping the corresponding connection information to obtain mapped connection information; and determining, according to the target test pattern and the mapped connection information, an initial test pattern that needs to be written into the physical interfaces.