Abstract: An ethylene bis-12-hydroxystearamide grafted glycidyl citrate (EBH-g-ECA) and a preparation method thereof are provided; the EBH-g-ECA can be used as a multifunctional auxiliary agent in a polymer material, and particularly has a chain extension and a crystal nucleation effect in a polyester polymer material. A heat-resistant polylactic acid continuously-extruded foamed material containing EBH-g-ECA is further provided. The continuous foaming technology can be realized by using the heat-resistant polylactic acid foamed material, and the prepared foamed product has a high heat resistance, a uniform appearance, a low density, and complete biodegradation. A polylactic acid foamed material preparation method for a heat-resistant is provided, which is easy to be industrialized and has a great significance for realizing the large-scale replacement of petroleum-based plastic disposable foamed products such as PP and PS.

Abstract: Methods and systems for container hyperlinking are disclosed. A method includes: receiving, by a computing device, a request for a source container; determining, by the computing device, a plurality of recommended target containers corresponding to the source container; displaying, by the computing device, the source container and the plurality of recommended target containers; receiving, by the computing device, a request to link the source container to at least one of the plurality of recommended target containers; and executing an application by dynamically linking the source container and the at least one of the plurality of recommended target containers. Each of the plurality of recommended target containers corresponding to the source container may be determined using information about a popularity of the recommended target container.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: An ethylene bis-12-hydroxystearamide grafted glycidyl citrate (EBH-g-ECA) and a preparation method thereof are provided; the EBH-g-ECA can be used as a multifunctional auxiliary agent in a polymer material, and particularly has a chain extension and a crystal nucleation effect in a polyester polymer material. A heat-resistant polylactic acid continuously-extruded foamed material containing EBH-g-ECA is further provided. The continuous foaming technology can be realized by using the heat-resistant polylactic acid foamed material, and the prepared foamed product has a high heat resistance, a uniform appearance, a low density, and complete biodegradation. A polylactic acid foamed material preparation method for a heat-resistant is provided, which is easy to be industrialized and has a great significance for realizing the large-scale replacement of petroleum-based plastic disposable foamed products such as PP and PS.

Abstract: Methods, computer program products, and systems are presented. There can be provided for example: obtaining user defined connectivity pattern information; and establishing commands for provisioning one or more network device for implementation of a network connection based on the user defined connectivity pattern information.

Abstract: Methods and systems for container hyperlinking are disclosed. A method includes: receiving, by a computing device, a request for a source container; determining, by the computing device, a plurality of recommended target containers corresponding to the source container; displaying, by the computing device, the source container and the plurality of recommended target containers; receiving, by the computing device, a request to link the source container to at least one of the plurality of recommended target containers; and executing an application by dynamically linking the source container and the at least one of the plurality of recommended target containers. Each of the plurality of recommended target containers corresponding to the source container may be determined using information about a popularity of the recommended target container.

Abstract: Methods, computer program products, and systems are presented. There can be provided for example: obtaining user defined connectivity pattern information; and establishing commands for provisioning one or more network device for implementation of a network connection based on the user defined connectivity pattern information.

Abstract: The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: An aqueous tumor-targeting liposome nanoparticle composition comprises an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises a legumain-targeting lipid component and polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: The invention provides novel inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2. The present invention includes pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier and/or diluents. The present invention includes compositions comprising a substantially pure compound of the invention and a pharmaceutically acceptable salt, steroisomer, or hydrate thereof: and a pharmaceutically acceptable excipient and/or diluents.

Abstract: In accordance with example embodiments, the method and system for film previsualization provides users with real-time previsualization guidance. In accordance with example embodiments, the method includes scanning a set using a mobile camera system; setting a master shot position in the set; tagging a position of one or more subjects within the set; calculating one or more camera positions based on the position of the master shot and the position of the one or more subjects; and displaying on the display of the mobile camera system the location of the one or more camera positions on a map of the set. In accordance with example embodiments, the method further includes overlaying selected composition guides over a camera live view on the display of the mobile camera system.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: The invention provides antibodies that specifically bind to PD-1, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: An aqueous tumor-targeting liposome nanoparticle composition comprises an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises a legumain-targeting lipid component and polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.

Abstract: The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.

Abstract: Methods, computer program products, and systems are presented. There can be provided for example: obtaining user defined connectivity pattern information; and establishing commands for provisioning one or more network device for implementation of a network connection based on the user defined connectivity pattern information.

Abstract: The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.