Abstract: The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a multi-well plate. One specific example method is a method of making multiple substantial replicas of a biomolecular content of a multi-well sample holder. Devices and kits for carrying out the described methods are also provided.

Abstract: Sensor includes electrodes on internal layer of multilayer printed circuit board, and sensing circuitry drives electrodes and reads signal having characteristic based upon capacitance between electrodes. Board may have first layer second layer, with electrodes between layers. One layer may be thicker than other layer such that capacitance external to board is primarily contributed from adjacent other layer. Electrodes may be on internal surface and sensing circuitry may be on opposing external surface. Components for sensing circuitry may be assembled to board such that board and components are multilayer printed circuit board assembly.

Abstract: In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infections by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.

Abstract: The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a multi-well plate. One specific example method is a method of making multiple substantial replicas of a biomolecular content of a multi-well sample holder. Devices and kits for carrying out the described methods are also provided.

Abstract: The present disclosure is directed to devices, arrays, kits and methods for detecting biomolecules in a tissue section (such as a fresh or archival sample, tissue microarray, or cells harvested by an LCM procedure) or other substantially two-dimensional sample (such as an electrophoretic gel or cDNA microarray) by creating “carbon copies” of the biomolecules eluted from the sample and visualizing the biomolecules on the copies using one or more detector molecules (e.g., antibodies or DNA probes) having specific affinity for the biomolecules of interest. Specific methods are provided for identifying the pattern of biomolecules (e.g., proteins and nucleic acids) in the samples. Other specific methods are provided for the identification and analysis of proteins and other biological molecules produced by cells and/or tissue, especially human cells and/or tissue.

Abstract: The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a multi-well plate. One specific example method is a method of making multiple substantial replicas of a biomolecular content of a multi-well sample holder. Devices and kits for carrying out the described methods are also provided.

Abstract: Provided herein are methods for preliminary analysis of suspect samples, which can be used in triaging possible contaminated sites (e.g., sites contaminated or thought to be contaminated by biowarfare agents). In some embodiments, the methods involve testing for the presence of protein in the suspect sample; optionally, the sample can also be tested for the presence of sugar, and/or for pH determination. Specific embodiment methods are carried out in tubes or other reaction vessels, others are carried out in a pad format, and still others are carried out in a test strip format. Kits for carrying out the described methods are also provided.

Abstract: Provided herein are methods for preliminary analysis of suspect samples, which can be used in triaging possible contaminated sites (e.g., sites contaminated or thought to be contaminated by biowarfare agents). In some embodiments, the methods involve testing for the presence of protein in the suspect sample; optionally, the sample can also be tested for the presence of sugar, and/or for pH determination. Specific embodiment methods are carried out in tubes or other reaction vessels, others are carried out in a pad format, and still others are carried out in a test strip format. Kits for carrying out the described methods are also provided.

Abstract: Provided herein are methods for preliminary analysis of suspect samples, which can be used in triaging possible contaminated sites (e.g., sites contaminated or thought to be contaminated by biowarfare agents). In some embodiments, the methods involve testing for the presence of protein in the suspect sample; optionally, the sample can also be tested for the presence of sugar, and/or for pH determination. Specific embodiment methods are carried out in tubes or other reaction vessels, others are carried out in a pad format, and still others are carried out in a test strip format. Kits for carrying out the described methods are also provided.

Abstract: A single stage dental implant for implantation in living jawbone having overlying gingiva comprises a generally cylindrical body section having an exterior surface for confronting the jawbone and a head section attached to the body section for extending through the overlying gingiva when the body section is confronting the jawbone. The head section has an end portion which is generally near an outer layer of the gingiva. The implant further includes a bore within the head section extending to an opening at the end portion of the head section. The bore is defined by first, second, and third walls. The first wall has internal threads. The second wall has a larger diameter than the first surface and is substantially cylindrical. The second wall extends from the first wall toward the end portion. The third wall extends from the second wall to the opening and flares toward the opening to a diameter that is wider than a diameter of the second wall.

Abstract: Provided herein are methods for preliminary analysis of suspect samples, which can be used in triaging possible contaminated sites (e.g., sites contaminated or thought to be contaminated by biowarfare agents). In some embodiments, the methods involve testing for the presence of protein in the suspect sample; optionally, the sample can also be tested for the presence of sugar, and/or for pH determination. Specific embodiment methods are carried out in tubes or other reaction vessels, others are carried out in a pad format, and still others are carried out in a test strip format. Kits for carrying out the described methods are also provided.

Abstract: A system and method is disclosed for in-field communication connectivity verification reporting between centralized on-line centers, and a number of in-field subscribing stations. The substations each have associated therewith an in-field product controlled by software which requires periodic upgrading, maintenance, service, and general monitoring. The system and method includes a computer program and a computer data signal embodied in a carrier wave for carrying out the process, which includes submitting customer and product data, and a user selected mode of notification of completion electronically to a centralized on-line center, which in turn creates a configuration module based on the submitted customer and product data. The configuration module is then transmitted to the subscribing station by the on-line center. The configuration module is loaded into the subscribing station to allow future communications between the on-line center and the subscribing station.

Abstract: The present disclosure is directed to devices, arrays, kits and methods for detecting biomolecules in a tissue section (such as a fresh or archival sample, tissue microarray, or cells harvested by an LCM procedure) or other substantially two-dimensional sample (such as an electrophoretic gel or cDNA microarray) by creating “carbon copies” of the biomolecules eluted from the sample and visualizing the biomolecules on the copies using one or more detector molecules (e.g., antibodies or DNA probes) having specific affinity for the biomolecules of interest. Specific methods are provided for identifying the pattern of biomolecules (e.g., proteins and nucleic acids) in the samples. Other specific methods are provided for the identification and analysis of proteins and other biological molecules produced by cells and/or tissue, especially human cells and/or tissue.

Abstract: A system and method is disclosed for in-field communication connectivity initialization and verification between centralized on-line centers, and a number of in-field subscribing stations. The substations each have associated therewith an in-field product controlled by software which requires periodic upgrading, maintenance, service, and general monitoring. The system and method includes a computer program and a computer data signal embodied in a carrier wave for carrying out the process, which includes submitting customer and product data electronically to a centralized on-line center, which in turn creates a configuration module based on the submitted customer and product data. The configuration module is then transmitted to the subscribing station by the on-line center. The configuration module is loaded into the subscribing station to allow future communications between the on-line center and the subscribing station.

Abstract: Provided herein are methods for preliminary analysis of suspect samples, which can be used in triaging possible contaminated sites (e.g., sites contaminated or thought to be contaminated by biowarfare agents). In some embodiments, the methods involve testing for the presence of protein in the suspect sample; optionally, the sample can also be tested for the presence of sugar, and/or for pH determination. Specific embodiment methods are carried out in tubes or other reaction vessels, others are carried out in a pad format, and still others are carried out in a test strip format. Kits for carrying out the described methods are also provided.

Abstract: A single stage dental implant for implantation in living jawbone having overlying gingiva comprises a generally cylindrical body section having an exterior surface for confronting the jawbone and a head section attached to the body section for extending through the overlying gingiva when the body section is confronting the jawbone. The head section has an end portion which is generally near an outer layer of the gingiva. The implant further includes a bore within the head section extending to an opening at the end portion of the head section. The bore is defined by first, second, and third walls. The first wall has internal threads. The second wall has a larger diameter than the first surface and is substantially cylindrical. The second wall extends from the first wall toward the end portion. The third wall extends from the second wall to the opening and flares toward the opening to a diameter that is wider than a diameter of the second wall.

Abstract: An implant for implantation into bone tissue having an exterior surface includes an elongated body and at least one thread. The elongated body has a distal end portion for being submerged in the bone tissue, a proximal end portion for being located near the exterior surface of the bone tissue, a central axis, and an outer surface. When viewed in cross-section, the elongated body has a non-circular cross-section. The non-circular cross-section includes a plurality of lobes and a plurality of dwells. Each of the plurality of dwells is disposed between adjacent ones of the plurality of lobes. The thread extends radially outward with respect to the central axis from the outer surface of the elongated body between the distal end portion and the proximal end portion. As the implant is screwed into the bone tissue, only the lobes on the elongated body engage the bone tissue. Because no contact exists between the dwells and the bone tissue, the amount of torque required to insert the implant is reduced.

Abstract: This present invention relates to a ratchet wrench and a torque indicator combined concentrically in a single housing. The ratchet wrench is useful for driving a fastener used in dentistry, such as an abutment screw that holds an abutment on a dental implant. In operation, the handle of the wrench can be rotated in one direction (e.g. clockwise) to impart torque on the fastener. When the handle is rotated in the opposite direction (e.g. counterclockwise), no torque is applied to the fastener as the handle is returned to a position where it is easy for the clinician to again rotate the handle to apply additional torque to the fastener. The return motion of the handle (e.g. counterclockwise rotation) may be stepless in operation which is brought about through a coiled clutch spring located in an annular space within a housing between the housing and a concentric driver member. To provide an indication of torque, a rotor body is supported coaxially within the driver member.

Abstract: A single stage dental implant for implantation in living jawbone having overlying gingiva comprises a generally cylindrical body section having an exterior surface for confronting the jawbone and a head section attached to the body section for extending through the overlying gingiva when the body section is confronting the jawbone. The head section has an end portion which is generally near an outer layer of the gingiva. The implant further includes a bore within the head section extending to an opening at the end portion of the head section. The bore is defined by first, second, and third walls. The first wall has internal threads. The second wall has a larger diameter than the first surface and is substantially cylindrical. The second wall extends from the first wall toward the end portion. The third wall extends from the second wall to the opening and flares toward the opening to a diameter that is wider than a diameter of the second wall.

Abstract: A set of dental impression components that may be used for either pick-up type (open tray) or transfer type (closed tray) impression molding techniques. The components are used with an impression material to fabricate a model at a site in a jawbone where an implant has been osseointegrated. The impression components include an impression coping having an outer surface with its bottom end configured to reside below the gingiva surrounding the implant. A passage exists through the impression coping which accepts a first means for attaching the impression coping to the implant for use in a pick-up type impression application. The passage also accepts a second means for attaching the impression coping to the implant for use in a transfer type impression application.