Abstract: A quantitative shear wave elasticity imaging method and system relates to the technical field of medical ultrasound imaging. The provided ultrasound quantitative elasticity imaging method and system are based on a sliding window linear fitting strain and use a two-dimensional linear fitting shear wave velocity detection algorithm, and thus, the anti-noise capability is stronger, and the result is more reliable. Moreover, where the load of an ultrasonic front-end storage and transmission module is not additionally in-creased, global ultrasonic quantitative elasticity imaging is realized, thereby significantly reducing the design difficulty of the ultrasound quantitative elasticity imaging system and the device cost.

Abstract: Methods, systems, and devices for jitter cancellation with automatic performance adjustment are described. Within a clock distribution system in an electronic device (e.g., a memory device), a jitter cancellation system may be configured to introduce delay between an input clock signal and output clock signal that is directly proportional to the supply voltage for the clock distribution system. In response to supply noise, the delay introduced by the jitter cancellation system may vary directly with respect to the supply voltage fluctuations and thus may offset fluctuations in the delay introduced by other components of the clock distribution system, which may vary inversely with respect to the supply voltage fluctuations. A control component within the jitter cancellation system may execute an algorithm to adjust or regulate the delay introduced by the jitter cancellation system, including its responsiveness to fluctuations in the supply voltage.

Abstract: A method and an apparatus for identifying a malicious account are disclosed. Implementation of the method includes: using an effective reading speed of an account in a known normal account set as a training sample, and determining distribution data of the effective reading speed of the account in the normal account set; determining an upper reading speed threshold for the account in the normal account set according to the distribution data; acquiring a reading speed of a to-be-determined account; and determining, if the reading speed of the to-be-determined account exceeds the reading speed threshold, that the to-be-determined account is a malicious account. In the method, a fixed threshold set manually is no longer used, and a threshold is set on a statistics-based theoretical basis and is no longer randomly set manually; therefore, a malicious account for fake book viewing can be accurately identified.

Abstract: Digital delay locked loop circuits, devices systems, and associated methods are provided and described. Such devices, systems, and methods utilize an open loop measurement for establishing a coarse delay lock.

Abstract: Methods, systems, and devices for jitter cancellation with automatic performance adjustment are described. Within a clock distribution system in an electronic device (e.g., a memory device), a jitter cancellation system may be configured to introduce delay between an input clock signal and output clock signal that is directly proportional to the supply voltage for the clock distribution system. In response to supply noise, the delay introduced by the jitter cancellation system may vary directly with respect to the supply voltage fluctuations and thus may offset fluctuations in the delay introduced by other components of the clock distribution system, which may vary inversely with respect to the supply voltage fluctuations. A control component within the jitter cancellation system may execute an algorithm to adjust or regulate the delay introduced by the jitter cancellation system, including its responsiveness to fluctuations in the supply voltage.

Abstract: Technology for a phase detector is described. The phase detector can include a reference clock. The phase detector can include a feedback clock. The phase detector can include a first latch operable to set a first latch output depending on a lead-lag status between the reference clock and the feedback clock. The phase detector can include a second latch that loads the lead-lag status when the reference clock and the feedback clock produce clock signals in a high state. The phase detector can include a third latch that loads the lead-lag status from the second latch when the reference clock and the feedback clock produce clock signals in a low state.

Abstract: Technology for a phase detector is described. The phase detector can include a reference clock. The phase detector can include a feedback clock. The phase detector can include a first latch operable to set a first latch output depending on a lead-lag status between the reference clock and the feedback clock. The phase detector can include a second latch that loads the lead-lag status when the reference clock and the feedback clock produce clock signals in a high state. The phase detector can include a third latch that loads the lead-lag status from the second latch when the reference clock and the feedback clock produce clock signals in a low state.

Abstract: An apparatus for a transmission electron microscope includes a housing configured to be attached to the transmission electron microscope; a plunger received in the housing and movable relative to the housing; a first set of pieces coupled to the plunger, the first piece being configured to move relative to the housing in response to the plunger moving relative to the housing; and a second set of pieces positioned in a fixed spatial relationship relative to each other, the second set of pieces and the first set of pieces forming a perimeter of an opening, an extent of the opening being continuously variable by moving the first set of piece relative to the second set of pieces.

Abstract: Examples may include techniques for dual-range clock duty cycle tuning of a clock signal used for an input/output data bus. A clock duty cycle of the clock signal is monitored to determine whether the clock duty cycle falls within a threshold of a 50 percent duty cycle. A dual-range tuning is then implemented until the clock duty cycle of the clock signal falls within the threshold.

Abstract: Examples may include techniques for dual-range clock duty cycle tuning of a clock signal used for an input/output data bus. A clock duty cycle of the clock signal is monitored to determine whether the clock duty cycle falls within a threshold of a 50 percent duty cycle. A dual-range tuning is then implemented until the clock duty cycle of the clock signal falls within the threshold.

Abstract: Digital delay locked loop circuits, devices systems, and associated methods are provided and described. Such devices, systems, and methods utilize an open loop measurement for establishing a coarse delay lock.

Abstract: A method and an apparatus for identifying a malicious account are disclosed. Implementation of the method includes: using an effective reading speed of an account in a known normal account set as a training sample, and determining distribution data of the effective reading speed of the account in the normal account set; determining an upper reading speed threshold for the account in the normal account set according to the distribution data; acquiring a reading speed of a to-be-determined account; and determining, if the reading speed of the to-be-determined account exceeds the reading speed threshold, that the to-be-determined account is a malicious account. In the method, a fixed threshold set manually is no longer used, and a threshold is set on a statistics-based theoretical basis and is no longer randomly set manually; therefore, a malicious account for fake book viewing can be accurately identified.

Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.

Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.

Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.

Abstract: Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.

Abstract: Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is, for example, hydrogen, azido, amino, oxalylamino, carboxy alkyl, alkoxycarbonyl alkyl, aminocarbonyl alkyl, or alkyl carbonylamino; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a pharmaceutically acceptable salt, stereoisomer, solvate, or hydrate thereof. Also disclosed are pharmaceutical compositions and methods of use of such compounds.

Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.

Abstract: Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.

Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.