Patents by Inventor Dan Tawfik
Dan Tawfik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9528106Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalizing genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: January 3, 2013Date of Patent: December 27, 2016Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20140187762Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: November 21, 2013Publication date: July 3, 2014Applicant: MEDICAL RESEARCH COUNCILInventors: Andrew Griffiths, Dan Tawfik, Armin Sepp
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Patent number: 8367326Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: June 21, 2007Date of Patent: February 5, 2013Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Patent number: 7897341Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: June 18, 2007Date of Patent: March 1, 2011Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik, Armin Sepp
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Publication number: 20090325236Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: December 19, 2008Publication date: December 31, 2009Inventors: Andrew Griffiths, Dan Tawfik, Armin Sepp
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Patent number: 7638276Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: June 4, 2004Date of Patent: December 29, 2009Assignee: 454 Life Sciences CorporationInventors: Andrew Griffiths, Dan Tawfik
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Patent number: 7582446Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: September 8, 2006Date of Patent: September 1, 2009Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20090053700Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: June 18, 2007Publication date: February 26, 2009Inventors: Andrew Griffiths, Dan Tawfik, Armin Sepp
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Publication number: 20080004436Abstract: The present invention is related to the field of compartmentalized libraries of genetic elements and the selection of biologically active molecules and the genes encoding same from said libraries. The selection assay of the invention utilizes water-in-oil emulsions and is particularly advantageous in applications in the field of directed-evolution, as exemplified herein for selection of protein inhibitors of DNA nucleases.Type: ApplicationFiled: November 15, 2005Publication date: January 3, 2008Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. at the Weizmann Institute of Science, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Dan Tawfik, Kalia Bernath, Shlomo Magdassi, Sergio Peisajovich
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Publication number: 20070259374Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: June 21, 2007Publication date: November 8, 2007Applicant: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Patent number: 7252943Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: compartmentalizing genetic elements into microcapsules; expressing the genetic elements to produce their respective gene products within the microcapsules; sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: June 3, 2004Date of Patent: August 7, 2007Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20070077579Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: September 8, 2006Publication date: April 5, 2007Inventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20070077572Abstract: The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulsion includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.Type: ApplicationFiled: May 24, 2006Publication date: April 5, 2007Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., YISSUM RESEARCH DEVELOPMENT COMPANY THE HEBREW UNIVERSITY OF JERUSALEM, MEDICAL RESEARCH COUNCILInventors: Dan Tawfik, Kalia Bernath, Amir Aharoni, Sergio Peisajovich, Andrew Griffiths, Enrico Mastrobattista, Shlomo Magdassi
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Patent number: 7138233Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity.Type: GrantFiled: October 3, 2002Date of Patent: November 21, 2006Assignee: Medical Research CouncilInventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20060205933Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.Type: ApplicationFiled: March 4, 2004Publication date: September 14, 2006Inventors: Dan Tawfik, Amir Aharoni, Leonid Gaydukov, Joel Sussman, Isreal Silman
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Publication number: 20060003347Abstract: The invention relates to a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: a) providing a population of genetic elements and expressing the genetic elements to produce their respective gene product(s), such that each molecule of gene product is linked to the genetic element encoding it at a ratio of one molecule of gene product per genetic element or less; b) compartmentalising the genetic elements into microcapsules; and c) sorting the genetic elements according to the activity of the gene product.Type: ApplicationFiled: March 11, 2005Publication date: January 5, 2006Inventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20050164239Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: October 1, 2004Publication date: July 28, 2005Inventors: Andrew Griffiths, Dan Tawfik, Armin Sepp
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Publication number: 20050069920Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: June 3, 2004Publication date: March 31, 2005Inventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20050042648Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: June 4, 2004Publication date: February 24, 2005Inventors: Andrew Griffiths, Dan Tawfik
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Publication number: 20050037392Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: June 11, 2004Publication date: February 17, 2005Inventors: Andrew Griffiths, Dan Tawfik, Armin Sepp