Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.

Abstract: The present invention offers a system for guiding drivers of vehicles going in the same direction to avoid encroaching each other's braking space. Encroachment may occur when a proximate vehicle merges too closely to a host vehicle or when the speed of a host vehicle and/or a proximate vehicle changes such that there is insufficient distance between the two vehicles, creating a hazard zone. The indicator system shall be mounted on a host vehicle and incorporate a gauge for determining the host vehicle's speed, one or more sensors to detect the relative proximity and speed of a proximate vehicle, a visual proximity indicator, and a controller for determining whether the proximate vehicle is too close to the host vehicle and operating the visual proximity indicator to signal the proximate vehicle it is within the hazard zone.

Abstract: A three-dimensional (3D) object production system and methods for 3D printing reactive components to form a thermoset product. The disclosure relates to Use of a 3D printer having a controller comprising one or more processors to print a 3D object. The disclosure also provides a 3D object production system and methods for 3D printing comprising adjusting one or more parameters of an at least one actuator to produce a 3D object based on a reaction rate between reactive components.

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

Abstract: Methods and devices for real time texture compression may include accessing graphics hardware incompatible compressed textures in a format incompatible with the GPU, and a metadata file associated with the graphics hardware incompatible compressed textures, wherein the metadata file includes at least one hint that provides information to use for compression of decompressed textures from the graphics hardware incompatible compressed textures into hardware compatible compressed textures. The methods and devices may include converting the graphics hardware incompatible compressed textures into the decompressed textures. The methods and devices may include selectively compressing the decompressed textures into the hardware compatible compressed textures usable by the GPU according to the at least one hint from the metadata file. The methods and devices may include transmitting the hardware compatible compressed textures to the GPU.

Abstract: A three-dimensional (3D) object production system and methods for 3D printing reactive components to form a thermoset product. The disclosure relates to Use of a 3D printer having a controller comprising one or more processors to print a 3D object. The disclosure also provides a 3D object production system and methods for 3D printing comprising adjusting one or more parameters of an at least one actuator to produce a 3D object based on a reaction rate between reactive components.

Abstract: Methods and devices for generating hardware compatible compressed textures may include accessing, at runtime of an application program, graphics hardware incompatible compressed textures in a format incompatible with a graphics processing unit (GPU). The methods and devices may include converting the graphics hardware incompatible compressed textures directly into hardware compatible compressed textures usable by the GPU using a trained machine learning model.

Abstract: Methods and devices for generating hardware compatible compressed textures may include accessing, at runtime of an application program, graphics hardware incompatible compressed textures in a format incompatible with a graphics processing unit (GPU). The methods and devices may include converting the graphics hardware incompatible compressed textures directly into hardware compatible compressed textures usable by the GPU using a trained machine learning model.

Abstract: Methods and devices for real time texture compression may include accessing graphics hardware incompatible compressed textures in a format incompatible with the GPU, and a metadata file associated with the graphics hardware incompatible compressed textures, wherein the metadata file includes at least one hint that provides information to use for compression of decompressed textures from the graphics hardware incompatible compressed textures into hardware compatible compressed textures. The methods and devices may include converting the graphics hardware incompatible compressed textures into the decompressed textures. The methods and devices may include selectively compressing the decompressed textures into the hardware compatible compressed textures usable by the GPU according to the at least one hint from the metadata file. The methods and devices may include transmitting the hardware compatible compressed textures to the GPU.

Abstract: Methods and devices for generating hardware compatible compressed textures may include accessing, at runtime of an application program, graphics hardware incompatible compressed textures in a format incompatible with a graphics processing unit (GPU). The methods and devices may include converting the graphics hardware incompatible compressed textures directly into hardware compatible compressed textures usable by the GPU using a trained machine learning model.

Abstract: A method for creating a three dimensional (3D) object from reactive components that form a thermoset product. In one embodiment, a method includes providing first and second reactive components that are effective to form the thermoset product. In one embodiment, the thermoset product includes a urethane and/or urea-containing polymer. In one embodiment, the first reactive component includes an isocyanate and the second reactive component includes a polyol having at least one terminal hydroxyl group, a polyamine having at least one amine that includes an isocyanate reactive hydrogen, or a combination of the polyol and the polyamine. In one embodiment, the first reactive component includes a prepolymer, and optionally the ratio of viscosity of the first and second reactive components is from 1:3 to 3:1. Also provided is a 3D object that includes a completely reacted thermoset product, and a thermoset system that includes a first and a second reactive component.

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibers which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

Abstract: A three-dimensional (3D) object production system and methods for 3D printing reactive components to form a thermoset product. The disclosure relates to Use of a 3D printer having a controller comprising one or more processors to print a 3D object. The disclosure also provides a 3D object production system and methods for 3D printing comprising adjusting one or more parameters of an at least one actuator to produce a 3D object based on a reaction rate between reactive components.

Abstract: Use of BUBR1 as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject, wherein the compound is a furazanobenzimidazole compound of general formula (I).

Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.

Abstract: Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

Abstract: Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

Abstract: Use of BUBR1 as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject, wherein the compound is a compound of general formula I wherein R represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; X represents a group C?Y, wherein Y stands for ox