Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to some 4,5,6,7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

Abstract: A process of making a tack-free gel is disclosed comprising the steps of providing a mold defining a mold cavity, the mold cavity comprising a plastic material; pouring or injecting a molten gel having a high molding temperature into the mold cavity; and forming the tack-free gel as a thin layer of plastic of the mold cavity is melted over the gel. The forming step further comprises cooling the gel from the molten state to a solidified state. The melting temperature of the plastic material is lower than the molding temperature of the gel; and the higher the temperature differential, the greater the melting of the plastic material and the thicker the layer of the plastic material on the surface of the gel. The mold may be formed of low-density polyethylene (LDPE).

Abstract: The present invention relates to compositions comprising nucleobases and/or sources of nucleobases and polysaccharides from extracts of fungi, yeasts or bacteria. Preferably, the compositions include Nucleoforce® or Nucleoforce® Dogs and AHCC®. Said compositions are useful in the treatment and prevention of immunosuppression, of the toxicity derived from chemotherapy or radiotherapy treatment, of diseases of the immune system, of cancer or an infection; and are also useful to stimulate the immune function in a mammal, including a human.

Abstract: A mechanism and a timepiece module independent of the bottom plate of a movement, of a simple and compact design. The timepiece mechanism includes a control stem (3) mounted in a pivoting manner and movable between at least two axial positions, a control pinion (11; 13) mounted so as to rotate with the control stem (3), and at least one actuating member (15, 24; 30) configured to engage with the control pinion (11; 13) when the control stem is occupying one of the axial positions. The control pinion (11; 13) is also coupled translationally to the control stem (3) when the latter moves from one to the other of the two positions. The module includes a case (2) containing the mechanism.

Abstract: The present invention relates to a timepiece movement allowing the arrangement of the various displays to be varied. The movement according to the invention comprises a first module provided both with a first frame and with at least one first wheel assembly mounted rotatably on the first frame, a second module provided both with a second frame and with at least one second wheel assembly mounted rotatably on the second frame, which first and second wheel assemblies are connected kinematically together, positioning means, and, connected to the first and second frames, means for fixing the modules to each other. The positioning means are positioned concentrically with the axis of rotation of either the first or second wheel assembly and are arranged so as to allow relative positioning of the two modules in a plurality of angular positions with reference to the axis of rotation of the wheel assembly with which the positioning means are concentric.

Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

Abstract: A timepiece movement for varying the arrangement of the different displays includes a first module provided with a first frame and at least a first mobile rotatingly mounted on the first frame, a second module provided with a second frame and at least a second mobile rotatingly mounted on the second frame, the first and second mobiles being kinematically connected to each other, elements for positioning and elements for attaching the modules to each other and associated with the first and second frames. The positioning elements are placed concentrically relative to the rotation axis of one of the first and second mobiles, and are arranged for allowing the relative positioning of the two modules in several angular positions relative to the rotation axis of the mobile to which the positioning elements are concentric. One of the first and second modules is a base module including a platen and a barrel, the barrel defining the first and the second mobile.

Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula (I) and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

Abstract: A method for selecting or designing a compound expected to modulate the activity of Leukotriene C4 synthase (LTC4S), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the catalytic site or a substrate binding region of LTC4S, wherein a three-dimensional structure of at least a part of the catalytic site or a substrate binding region of LTC4S is compared with a three-dimensional structure of a compound, and a compound that is predicted to interact with the said catalytic site or substrate binding region is selected.

Abstract: There is provided a method and a device for detecting interfering radio technologies. The method in accordance with the invention is applicable in order to detect and identify possible interfering technologies that can be found, e.g., in the 2.4 GHz ISM band, by use of a device having a single transceiver which is adapted to employ a first wireless radio access technology. For example, a device having an IEEE 102.15.4 cordless transceiver is able to identify according to the method in accordance with the invention radio signals sent by disquieters which use other interfering technologies by use of only this transceiver. The device can for example be a sensor of a wireless body sensor network.

Abstract: The present invention is a stapler having a housing; a body (30) pivotally secured to the housing and a second rod extending from the body.

Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula (I) and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

Abstract: A instrument and method of applying house wrap to exterior walls. The instrument or tool or apparatus allows the roll of house wrap to be positioned with an axis of rotation substantially parallel with the wall. The house wrap can then be rolled and applied onto the wall as the apparatus is moved along the length of the wall. The apparatus can roll along an upper surface of the wall so that the apparatus need not be lifted. The apparatus also may have a guide wheel to maintain the house wrap roll at a substantially fixed distance from the wall.

Abstract: A rotary position sensor measures the relative angular position (within a range of?180°) of a housing or stator and a rotor. The housing carries a galvanomagnetic sensing element and is adapted for fixation to a relatively fixed portion of a host system. The rotor carrying a magnet is disposed for rotation about a fixed axis with respect to the stator and is interconnected to a relatively moving portion of the host system through intermediate linkage. The magnet is juxtaposed in substantially axial alignment with the galvanomagnetic sensing element for magnetic interaction therewith. The housing defines a cavity to receive potting material for encasing the galvanomagnetic sensing element and an adjacent buffer cavity interconnected by a weir, which diverts ant excess potting material into the buffer cavity.

Abstract: A instrument and method of applying house wrap to exterior walls. The instrument or tool or apparatus allows the roll of house wrap to be positioned with an axis of rotation substantially parallel with the wall. The house wrap can then be rolled and applied onto the wall as the apparatus is moved along the length of the wall. The apparatus can roll along an upper surface of the wall so that the apparatus need not be lifted. The apparatus also may have a guide wheel to maintain the house wrap roll at a substantially fixed distance from the wall.

Abstract: A non-contact linear absolute position sensor includes a first magnetic encoder having n+1 pole pairs, a second magnetic encoder having n pole pairs and located and aligned with the first magnetic encoder so as to cover a linear distance. The magnetic encoders are affixed to a traveling body. Two pairs of Hall Effect sensors are located near each of the first and second magnetic encoders and are configured to generate linear position signals. A processor is provided to process the linear position signals to generate an output signal indicative of a linear absolute position of the traveling body.

Abstract: A non-contact linear absolute position sensor includes a first magnetic encoder having n+1 pole pairs, a second magnetic encoder having n pole pairs and located and aligned with the first magnetic encoder so as to cover a linear distance. The magnetic encoders are affixed to a traveling body. Two pairs of Hall Effect sensors are located near each of the first and second magnetic encoders and are configured to generate linear position signals. A processor is provided to process the linear position signals to generate an output signal indicative of a linear absolute position of the traveling body.

Abstract: A robust, low cost, compact and highly accurate rotary position sensor is disclosed for measuring the relative angular position (within a range ?180°) of a housing or stator and a rotor. The housing carries a galvanomagnetic sensing element and is adapted for fixation to a relatively fixed portion of a host system. The rotor carrying a magnet is disposed for rotation about a fixed axis with respect to the stator and is interconnected to a relatively moving portion of the host system through intermediate linkage. The magnet is juxtaposed in substantially axial alignment with the galvanomagnetic sensing element for magnetic interaction therewith. The housing defines a cavity to receive potting material for encasing the galvanomagnetic sensing element and an adjacent buffer cavity interconnected by a weir, which diverts ant excess potting material into the buffer cavity.