Abstract: A stimulation system for a patient is provided. The system comprises: at least one implantable device comprising at least one implantable antenna; and an external device comprising at least one external antenna, wherein the at least one external antenna transfers power to the at least one implantable antenna. The at least one implantable device delivers therapy to the patient. A patient attachment device or body covering positions the at least one external antenna relative to the patient.

Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.

Abstract: Provided herein are methods of treating cancer in a human subject, comprising administering to the subject: i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor. Further provided herein are kits comprising i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor.

Abstract: A drive sprocket comprising a plurality of teeth for meshing with a drive member to transmit rotary motion, the drive member including a plurality of engagement pockets engaging the teeth of the drive sprocket, wherein each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface, wherein the first contact location is radially offset from the second contact location.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: A transmission system can include a drive sprocket and a drive member adapted to mesh with the drive sprocket. The drive sprocket can include a plurality of teeth for meshing with the drive member to transmit rotary motion, and the drive member can include a plurality of engagement pockets adapted to engage the teeth of the drive sprocket.

Abstract: A drive sprocket comprising a plurality of teeth for meshing with a drive member to transmit rotary motion, the drive member including a plurality of engagement pockets engaging the teeth of the drive sprocket, wherein each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface, wherein the first contact location is radially offset from the second contact location.

Abstract: A power transmission drive member adapted to mesh with a drive sprocket to transmit rotary motion, the drive member comprising a plurality of engaging mechanisms, each comprising an engaging body comprising an engagement pocket adapted to engage with the drive sprocket, each of which engagement pockets comprising a first engaging surface and a second engaging surface spaced apart from the first engaging surface, the first and second engaging surfaces forming an engaging surface pair, which pair is rotatable about an engaging mechanism rotational axis, wherein the power transmission drive member comprises a carrier, which carrier is articulated and is adapted to support the plurality of engaging mechanisms.

Abstract: A drive sprocket comprising a plurality of teeth for meshing with a drive member to transmit rotary motion, the drive member including a plurality of engagement pockets engaging the teeth of the drive sprocket, wherein each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface, wherein the first contact location is radially offset from the second contact location.

Abstract: A drive sprocket can include a plurality of teeth for meshing with a drive member to transmit rotary motion. The drive member can include a plurality of engagement pockets engaging the teeth of the drive sprocket, where each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface.

Abstract: A surgical instrument includes a body, a shaft, and an end effector. The end effector includes a staple cartridge unit having a housing and an anvil configured to form staples ejected from the housing into tissue. The end effector also includes a cartridge retaining member having an opposed pair of jaws configured to cooperate to grip the housing of the staple cartridge unit. The end effector further includes a deflectable retention member configured to removably secure the housing of the staple cartridge unit to the cartridge retaining member. The deflectable retention member is presented by one of the staple cartridge unit or the cartridge retaining member, and is configured to be deflected relative to a portion of the one of the staple cartridge unit or the cartridge retaining member from an undeflected state to a deflected state by the other of the staple cartridge unit or the cartridge retaining member.

Abstract: A presentation system capable of detecting one or more gestures and contacts on a touch sensitive display. The presentation system can displaying indicia of such contacts, such as when a user writes with a fingertip, and can remove or alter such indicia responsive to other gestures and contacts. The system can accurately distinguish between types of gestures detected, such as between a writing gesture and an erasing gesture, on both large and small touch sensitive displays, thereby obviating the need for a user to make additional selective inputs to transition from one type of gesture to another. The system can determine how long to keep user annotations displayed during a presentation, based on the nature of the gesture used to make the annotations and the context in which they are made.

Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.

Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: In addition to drilling operations a hard rock drill rig is used to induce seismic energy into subsurface rock formations. In quartz rich rock the seismic energy will partially convert to electrical energy thereby allowing for the prospecting of ore-bearing quartz veins. Seismic energy and electric energy are detected by a sensor array. The electric energy is used to infer the presence of piezoelectric materials in the rock formations, and such materials are mapped using the detected seismic energy and electric energy.

Abstract: A transmission system can include a drive sprocket and a drive member adapted to mesh with the drive sprocket. The drive sprocket can include a plurality of teeth for meshing with the drive member to transmit rotary motion, and the drive member can include a plurality of engagement pockets adapted to engage the teeth of the drive sprocket.

Abstract: A method includes positioning a downhole acquisition tool in a wellbore in a geological formation. The method includes operating a pump module to gather information for a fluid outside of the downhole acquisition tool that enters the downhole acquisition tool from a first flowline, a second flowline, or both while the downhole acquisition tool is within the wellbore. Operating the pump module includes controlling a valve assembly to a first valve configuration that enables the fluid to flow into the downhole tool via the first flowline fluidly coupled to a first pump module.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.