Abstract: A drive sprocket can include a plurality of teeth for meshing with a drive member to transmit rotary motion. The drive member can include a plurality of engagement pockets engaging the teeth of the drive sprocket, where each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: A power transmission drive member adapted to mesh with a drive sprocket to transmit rotary motion, the drive member comprising a plurality of engaging mechanisms, each comprising an engaging body comprising an engagement pocket adapted to engage with the drive sprocket, each of which engagement pockets comprising a first engaging surface and a second engaging surface spaced apart from the first engaging surface, the first and second engaging surfaces forming an engaging surface pair, which pair is rotatable about an engaging mechanism rotational axis, wherein the power transmission drive member comprises a carrier, which carrier is articulated and is adapted to support the plurality of engaging mechanisms.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: A drive sprocket comprising a plurality of teeth for meshing with a drive member to transmit rotary motion, the drive member including a plurality of engagement pockets engaging the teeth of the drive sprocket, wherein each tooth has a tooth profile defined by a first side comprising a first engagement surface and an opposite second side comprising a second engagement surface, which engagement surfaces are configured such that when driven, a tooth meshes to the engagement pocket at a first contact location on the first engagement surface and also at a second contact location on the second engagement surface, wherein the first contact location is radially offset from the second contact location.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: Respective embodiments disclosed herein include methods and apparatuses (1) for surveying a mine bench or other material body using at least seismic data obtained via geophone and measurement module data synchronized via a wireless link; (2) for generating hyperspectral panoramic imaging data of a blast hole or other borehole; or (3) for allowing a neural network to facilitate a differential blast design that targets a first bench part more weakly than the differential blast design targets a second bench part (along the same mine bench) at least partly based on data indicative of a much higher concentration of a valuable material in the second bench part than in the first.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.

Abstract: Systems and methods for variable rate steam injection, including via solar power for enhanced oil recovery, are disclosed. Several embodiments include using the variable nature of solar-generated steam to improve the efficiency and cost-effectiveness of enhanced oil recovery processes. In particular embodiments, the variable rate injection can provide more uniform steam distribution in an oil-bearing formation, at a lower cost than if the same amount of steam were provided on a continuous basis.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.

Abstract: A vibration while drilling acquisition and signal processing system include a sensor assembly affixable to a drill string in a drilling unit and a sensor for detecting vibrations in the drill string. A first processor is in signal communication with the sensor and is programmed to digitally sample signals from the sensor. A transmitter in signal communication with the first processor communicates the digitized signals to a device disposed apart from the drill string. The first processor is programmed to operate the signal. An electric power source to provides power to the sensor, the first processor and transmitter. Either or both the first processor and a second processor associated with the device is programmed to calculate properties of rock formations using only detected vibration signals from the drill string.

Abstract: A method for determining properties of rock formations using drill string vibration measurements includes entering into a processor signals corresponding to vibrations detected along a rotating part of a drill string while drilling a borehole. The vibration signals are transformed into transformed signals representing elastic response of the drill string, the rock formations and borehole fluid to a filtered impulse originating at a known location along the drill string. Properties of the rock formations are calculated using the transformed signals.

Abstract: Provided are compositions comprising fusion proteins, polynucleotides and/or expression vectors with therapeutic utility for suppressing and/or treating cancer, as well as medical uses of these agents, and methods of treatment in which they are used. A fusion protein of the invention comprises an amino acid sequence that provides the apoptosis-inducing activity of TRAIL, and a membrane-anchoring amino acid sequence. The amino acid sequence that provides the apoptosis-inducing activity of TRAIL comprises the extracellular domain of TRAIL, or a fragment or variant thereof. A fusion protein comprising an amino acid sequence from TRAIL that is able to induce apoptosis, and a second sequence that anchors the first sequence to the cell membrane, is markedly more effective at reducing viability of TRAIL receptor positive cells than the naturally occurring (“wild type”) TRAIL protein itself.

Abstract: Systems and methods for variable rate steam injection, including via solar power for enhanced oil recovery, are disclosed. Several embodiments include using the variable nature of solar-generated steam to improve the efficiency and cost-effectiveness of enhanced oil recovery processes. In particular embodiments, the variable rate injection can provide more uniform steam distribution in an oil-bearing formation, at a lower cost than if the same amount of steam were provided on a continuous basis.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: Respective embodiments disclosed herein include methods and apparatuses (1) for surveying a mine bench or other material body using at least seismic data obtained via geophone and measurement module data synchronized via a wireless link; (2) for generating hyperspectral panoramic imaging data of a blast hole or other borehole; or (3) for allowing a neural network to facilitate a differential blast design that targets a first bench part more weakly than the differential blast design targets a second bench part (along the same mine bench) at least partly based on data indicative of a much higher concentration of a valuable material in the second bench part than in the first.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nano particles in medicine.

Abstract: A cartridge which contains medicine/substance that is consumed by heating and inhaling when connected to a smartphone charging port for heating power and application control of user access, dosing, and data collection. The duration of use is limited to smartphone charging port connectivity, eliminating risk of accidental overheating. Application control of access ensures user and dosing specifications, preventing non-authorized user/accidental excess consumption. Data collection via this method of consumption informs and guides subsequent user cartridge/dosing decisions and recommendations.

Abstract: A presentation system capable of detecting one or more gestures and contacts on a touch sensitive display. The presentation system can displaying indicia of such contacts, such as when a user writes with a fingertip, and can remove or alter such indicia responsive to other gestures and contacts. The system can accurately distinguish between types of gestures detected, such as between a writing gesture and an erasing gesture, on both large and small touch sensitive displays, thereby obviating the need for a user to make additional selective inputs to transition from one type of gesture to another. The system can determine how long to keep user annotations displayed during a presentation, based on the nature of the gesture used to make the annotations and the context in which they are made.