Abstract: Ablation devices useful for removing nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a cannula having an opening at a distal tip of the cannula, the opening configured for suction of a surgical site, and a movable tissue capture member having a portion disposed within the opening or adjacent to the cannula, the movable tissue capture member configured to capture tissue when moved in a first position. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.

Abstract: A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

Abstract: A filling system for delivery of at least one substance to a covering is provided. The filling system comprises at least a funnel shaped container and a plunger. The funnel shaped container includes a scoop portion connected to a hollow barrel. The barrel is configured for insertion into the covering, the plunger adapted for pushing the at least one substance down the hollow barrel into the covering. The filling system can also include a spatula. A kit including a funnel shaped container, a plunger adapted to push a substance down the barrel of the funnel shaped container, a spatula, a retainer for keeping the kit elements in place and trays for protecting them from the environment are also provided. A method of use utilizing the filling system is also provided.

Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

Abstract: The invention relates to a composition comprising an aqueous admixture of ceramic particles, polysaccharide, a therapeutic agent and, optionally, a polymer, and methods of using the same. The present invention provides a flowable bone void filler for use in medical situations where bone regeneration is desired. In an exemplary embodiment the bone void filler comprises a polysaccharide, a ceramic material and a polymer that exhibits thermosetting properties such that it exists as a viscous liquid at room temperatures and as a gel at about body temperature. In another exemplary embodiment the bone void filler comprises a polysaccharide, a ceramic material, a polymer that exhibits thermosetting properties such that it exists as a viscous liquid at room temperature and as a gel at about body temperatures, and a therapeutic agent.

Abstract: A bone material comprising a coherent mass of cartridge milled and demineralized bone fibers is provided, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material comprising a lyophilized coherent mass of cartridge milled and demineralized bone fibers is provided, the lyophilized coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a method of making an implantable bone material is provided, the method comprising drying a coherent mass of cartridge milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass.

Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

Abstract: A filling system for delivery of at least one substance to a covering is provided. The filling system comprises at least a funnel shaped container and a plunger. The funnel shaped container includes a scoop portion connected to a hollow barrel. The barrel is configured for insertion into the covering, the plunger adapted for pushing the at least one substance down the hollow barrel into the covering. The filling system can also include a spatula. A kit including a funnel shaped container, a plunger adapted to push a substance down the barrel of the funnel shaped container, a spatula, a retainer for keeping the kit elements in place and trays for protecting them from the environment are also provided. A method of use utilizing the filling system is also provided.

Abstract: A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

Abstract: A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

Abstract: A surgical procedure for preparing a graft for insertion in an opening in a human body, according to which a mold is formed in the opening and transferred from the opening to a position adjacent a stylus. A contour of the mold is traced with the stylus; and the tracing movement of the stylus is transferred to corresponding movement of a cutting member so that the cutting member cuts the same contour in the graft.

Abstract: A filling system for delivery of at least one substance to a covering is provided. The filling system comprises at least a funnel shaped container and a plunger. The funnel shaped container includes a scoop portion connected to a hollow barrel. The barrel is configured for insertion into the covering, the plunger adapted for pushing the at least one substance down the hollow barrel into the covering. The filling system can also include a spatula. A kit including a funnel shaped container, a plunger adapted to push a substance down the barrel of the funnel shaped container, a spatula, a retainer for keeping the kit elements in place and trays for protecting them from the environment are also provided. A method of use utilizing the filling system is also provided.

Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.

Abstract: A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

Abstract: An expansion device includes an inflatable balloon moveable from an unexpanded configuration to an expanded configuration configured to pass through soft tissue between two adjacent teeth of a patient when in the unexpanded configuration. The an expansion device also includes an inflation tube having one end connected to the inflatable balloon and another end serving as an entry port for an inflation fluid. The inflatable balloon has a triangular shape when in the expanded configuration.

Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.

Abstract: The invention relates to resolvins and their use as anti-inflammatory compounds. The resolvins may be administered in a variety of forms, including drug depots comprising polymers or lipids. The pharmaceutical formulations of the present invention may be used to treat a variety of conditions including acute pain and chronic pain.

Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.

Abstract: A system for treating a tissue site is provided, the system including a graft preparation device for treating a tissue site, the preparation device including an elongate inner member having a proximal end connected to a handle and a distal end including an abrasive end configured for abrading the tissue site, and an elongate outer member movably attached to the elongate inner member, the elongate outer member including a tapered end. The elongate outer member is movable between a first position for covering the abrasive end and a second position for exposing the abrasive end. Following treatment of the tissue site using the graft preparation device to remove soft tissue and cause bleeding, the tissue site is distracted and an implant body is inserted into the tissue site.

Abstract: A surgical procedure according to which a slotted film is positioned over an area of a bone to be milled; and a portion of a milling assembly is inserted in the defect, with another portion of the assembly extending through one of the slots so that the slot can be used as a guide to mill the bone.