Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet, a well having a passage, and a valve membrane comprising a conical portion having a base and a tip. The conical portion is configured to fit within the passage of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A retrograde disposable intravenous (IV) set is disclosed. The IV set includes a diverter housing between upper and lower portions of a fluid line, the diverter housing including a lower end and an upper end extending away from the lower end and the fluid line to a syringe port located in the upper end, and a diverter member within the diverter housing and configured to move within the diverter housing from a first position, at which a first opening through the diverter member forms a first fluid pathway between the upper portion and the lower portion of the fluid line, to a second position, at which the first fluid pathway is blocked and a second fluid pathway is formed between the upper portion of the fluid line and a syringe port. Retrograde infusion may occur when the diverter member is in the second position.

Abstract: A syringe pump can be operated to produce fluid flow from a syringe installed therein. Features of the pump can produce a desired rapid commencement of flow followed by smooth delivery uninterrupted by stiction-induced slowing and acceleration. A stiff drivetrain can facilitate detection of excessive forces indicative of friction at a stopper-wall interface. The motor drive, gearing, and control parameters can enable customized acceleration patterns to determine optimal initial stage advancement to provide fluid delivery. These patterns can minimize or eliminate the delay in commencement of flow by overcoming both mechanical slack remaining and syringe stopper slack. To avoid flow irregularities produced by stiction forces in the stopper further, a mechanical vibration can be provided to the syringe and/or barrel to introduce movement of the stopper-wall interface, reducing the creation of high static friction coefficients.

Abstract: A method may include capturing, by a camera at an infusion pump, one or more images of the pump loaded with an infusion set. A machine learning model may be applied to the images to detect nonconformities that may be present in the images of the pump loaded with the infusion set. Examples of nonconformities include a misload of the intravenous set in which an upper fitment, a lower fitment, and/or a tubing of the intravenous set is misplaced within the pump. In response to an output of the machine learning model indicating a presence of a nonconformity in the one or more images of the pump loaded with the infusion set, a corrective action may be performed. For example, the pump may be prevented from performing an infusion and a message identifying the nonconformities may be generated. Related methods and articles of manufacture are also disclosed.

Abstract: A wasting station for receiving a wasted medication from a medication dispenser is provided. The wasting station includes a base and a locking mechanism. The base includes a weight sensor to measure a weight of a waste container supported by the base. The wasting station can determine, based on the measured weight, a volume of the wasted medication positioned within the waste container. The locking mechanism includes a first end coupled to the base. The locking mechanism also includes a second end coupled to the waste container when the locking mechanism is in a first position and decoupled from the waste container when the locking mechanism moves from the first position to a second position, thereby allowing for removal of the waste container.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet, a well having a passage, and a valve membrane comprising a conical portion having a base and a tip. The conical portion is configured to fit within the passage of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A pumping mechanism includes a plurality of peristaltic pumping actuators to compress adjacent portions of a first portion of an at least partially compressible pumping element having an inlet that is upstream of an outlet. The plurality of pumping actuators further reciprocate at a common drive frequency with a first phase offset between each adjacent pair of pumping actuators. The pumping mechanism also includes one compensation actuator to compress a second portion of the compressible pumping element disposed between the first portion and the outlet. The compensation actuator reciprocates at an optimal displacement and at a modulation frequency that is an integer multiple of the fundamental drive frequency and with a second phase offset between the compensation actuator and the adjacent pumping actuator.

Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet and a conical well having an opening, a beveled surface and a bottom, and a valve membrane comprising a conical potion having a base and a tip. The conical portion is configured to fit within the conical well of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A retrograde disposable intravenous (IV) set is disclosed. The IV set includes a diverter housing between upper and lower portions of a fluid line, the diverter housing including a lower end and an upper end extending away from the lower end and the fluid line to a syringe port located in the upper end, and a diverter member within the diverter housing and configured to move within the diverter housing from a first position, at which a first opening through the diverter member forms a first fluid pathway between the upper portion and the lower portion of the fluid line, to a second position, at which the first fluid pathway is blocked and a second fluid pathway is formed between the upper portion of the fluid line and a syringe port. Retrograde infusion may occur when the diverter member is in the second position.

Abstract: Systems and methods are provided for intermittent microinfusion. A system may include a pump and an IV set that includes a y-port valve disposed below a pump interface portion of the IV tubing. The y-port valve may include an internal valve member that allows fluid to flow from the pump to a patient when no syringe is attached to the y-port. The internal valve member may be moved by the attachment of a syringe containing the medication to be infused to the y-port such that the fluid pathway from the pump to the patient is blocked and fluid from the syringe can be injected into the IV tubing between the y-port valve and the pump. The pump may retrograde pump the medication into the tubing via the y-port valve and then forward pump the medication to the patient when the syringe is removed from the y-port.

Abstract: A syringe pump can be operated to produce fluid flow from a syringe installed therein. Features of the pump can produce a desired rapid commencement of flow followed by smooth delivery uninterrupted by stiction-induced slowing and acceleration. A stiff drivetrain can facilitate detection of excessive forces indicative of friction at a stopper-wall interface. The motor drive, gearing, and control parameters can enable customized acceleration patterns to determine optimal initial stage advancement to provide fluid delivery. These patterns can minimize or eliminate the delay in commencement of flow by overcoming both mechanical slack remaining and syringe stopper slack. To avoid flow irregularities produced by stiction forces in the stopper further, a mechanical vibration can be provided to the syringe and/or barrel to introduce movement of the stopper-wall interface, reducing the creation of high static friction coefficients.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, and two opposing longitudinal edge sections. The rigid body may include a controllable fluid pathway defined in part by the compliant membrane and extending from an inlet port to an outlet port. The pump cassette may include a slider coupled to the two opposing longitudinal edge sections and longitudinally articulable with respect to the rigid body.

Abstract: Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body including two opposing edge sections, an inlet port, an outlet port, and a controllable fluid pathway extending from the inlet port to the outlet port. The pump may include a slider coupled to the two opposing edge sections and articulable with respect to the rigid body; and a flow stop valve operably coupled to the controllable fluid pathway.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, and two opposing longitudinal edge sections. The rigid body may include a controllable fluid pathway defined in part by the compliant membrane and extending from an inlet port to an outlet port. The pump cassette may include a piston disposed at least partially within the rigid body such that movement of the piston varies a volume of a pump chamber defined within the controllable fluid pathway.

Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet and a conical well having an opening, a beveled surface and a bottom, and a valve membrane comprising a conical potion having a base and a tip. The conical portion is configured to fit within the conical well of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet and a conical well having an opening, a beveled surface and a bottom, and a valve membrane comprising a conical portion having a base and a tip. The conical portion is configured to fit within the conical well of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A pump cassette includes fluid lumen adapted for passage of an infusion fluid toward a patient. A rotary valve assembly can be actuated to regulate fluid flow through the fluid lumen and a frame is coupled to the fluid lumen and the valve assembly. The frame is adapted to be inserted into a seat of a pump device, wherein the frame provides a platen relative to the fluid lumen. The frame is configured to be inserted into the seat only when aligned in a predetermined orientation relative to the seat.