Abstract: A mobile robot includes at least one processor, and at least one memory storing instructions that, when executed by the at least one processor, cause the mobile robot to generate a set of next consecutive waypoints, determine a local planner based on the set of next consecutive waypoints, and output a velocity pair for navigating the mobile robot, based on the determined local planner.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for multi-region joint detection. In some implementations, a method for identifying variants using multi-region joint detection in genetic sample sequences includes generating a set of candidate diplotypes mapped to at least two different regions in a reference sequence; generating a set of joint diplotype candidates comprising two or more candidate diplotypes of the set of candidate diplotypes; querying, for diplotypes at one or more locations of the at least two different regions in the reference sequence, a population database comprising genetic sequences of previously sequenced organisms; determining one or more values representing the frequency of specific diplotypes occurring within the genetic sequences of previously sequenced organisms; and generating, using the one or more values, an indication that the variant of the first joint diplotype candidate is an actual variant.

Abstract: This disclosure describes methods, non-transitory computer readable media, and systems that can utilize methylation sequencing assay data to generate genotype calls efficiently and accurately for a target genomic sample. In some implementations, the disclosed system identifies the target genomic sample's nucleotide reads comprising nucleobases converted by a methylation sequencing assay. The disclosed system can determine variant calls based on aligning the nucleotide reads with a reference genome. To account for errors introduced by the methylation sequencing assay, in some cases, the disclosed system corrects or modifies genotype-likelihood metrics for a subset of candidate variant calls. The disclosed system further imputes genotype calls based on such modified genotype-likelihood metrics and a comparison of a subset of variant calls with marker variants from a reference panel.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for generating a target-variant-reference panel comprising a target-variant position with target-variant indicators or using the target-variant-reference panel to impute a genotype call for the corresponding target variant. In particular, in one or more embodiments, the disclosed systems generate an initial reference panel including a variety of phased genomic samples of different haplotypes. The disclosed systems further add a target-variant position to the initial reference panel to indicate a presence or absence of a target variant, thereby creating a target-variant-reference panel comprising a target-variant position with target-variant indicators.

Abstract: An apparatus is disclosed, the apparatus comprising means for assigning a plurality of user devices, flows and/or data bearers to a network slice of a plurality of network slices, determining whether transmissions via the network slice satisfy a target and, based on determining whether transmissions via the network slice satisfy the target, adjusting a weighted resource allocation metric associated with each user device, flow and/or data bearer of said network slice using one or more calculated offsets, the offsets being calculated so that respective weights, associated with each user device, flow or data bearer on said network slice, are adjusted such that their resource allocations are substantially proportional to their associated weight. The apparatus means may also allocate to the user devices, flows and/or data bearers, based on their respective adjusted weighted resource allocation metrics, transmission resources of the network.

Abstract: Wireless transmissions via a wireless network may be improved by using network slice tokens. One or more user devices may be assigned to a network slice or several network slices, and a computing device may determine whether transmissions via the network slice satisfy target(s). Based on whether the target(s) are satisfied, a token counter value associated with the network slice may be adjusted. A weight associated with each flow or user may be determined based on the token counter value. A computing device may allocate transmission resources to the flow or user based on the weight.

Abstract: Methods are provided for metering the usage, on a group of lines subject to a group user agreement, of the data processing capacity of a network. Implementations include steps of receiving usage reports from respective lines of the group at least when usage quotas granted to the lines are exhausted; maintaining a total, over the group, of usage that has been reported by the lines and of outstanding usage quotas that have been granted to the lines; and maintaining a comparison between the total outstanding group quota and a limit that depends on the total reported group usage, so as to detect violation events when said quota violates the limit. Upon occurrence of violation events, instructions for the processors serving respective lines to reallocate quota are sent selectively.

Abstract: In one embodiment, the method includes determining feasibility for a potential transmission based on a current schedule of active transmissions. The current schedule of active transmissions includes active transmissions over multiple carriers and at multiple transmission rates. The potential transmission is at a start time on a radio frequency carrier at a data transmission rate by a user terminal. A transmission duration is determined if the potential transmission is determined to be feasible. A message is sent to the user terminal. if the potential transmission is determined to be feasible. The message may direct the user terminal to receive the potential transmission on the radio frequency carrier at the data transmission rate at the start time. The current schedule is updated according to the feasibility determination.

Abstract: A group server maintains an outstanding quota granted to a group of lines at a variable margin at at most a maximum total standby allocation to ensure a group data usage of the group surpasses a current notification milestone by at most an accuracy requirement associated with the current notification milestone, the group server including a processor configured to update a tally of the group data usage based on usage update messages, allocate, to lines requesting a new quota allocation, a current quota of a plurality of quotas associated with the current notification milestone, in response to the tally of the group data usage plus the outstanding quota being within the variable margin, and allocate, to lines requesting a new quota allocation, a next quota of the plurality of quotas, in response to the tally of the group data usage plus the outstanding quota exceeding the variable margin.

Abstract: In one embodiment, the method includes determining feasibility for a potential transmission based on a current schedule of active transmissions. The current schedule of active transmissions includes active transmissions over multiple carriers and at multiple transmission rates. The potential transmission is at a start time on a radio frequency carrier at a data transmission rate by a user terminal. A transmission duration is determined if the potential transmission is determined to be feasible. A message is sent to the user terminal. if the potential transmission is determined to be feasible. The message may direct the user terminal to receive the potential transmission on the radio frequency carrier at the data transmission rate at the start time. The current schedule is updated according to the feasibility determination.

Abstract: The present invention is directed to a tray handler for stacking and de-stacking ophthalmic prescription trays. The tray handler includes a plurality of spaced clamp assemblies defining a stack area along a conveyor, a lift plate, and first and second actuators. The lift plate is operably disposed within the stack area. The first actuator is operably associated with the clamp assemblies, which are inwardly and outwardly moveable relative the lift plate upon actuation of the first actuator. The second actuator is operably associated with the lift plate, which is vertically moveable within the stack area upon actuation of the second actuator. A controller is in communication with the first and second actuators and controls actuation thereof. A method of handling ophthalmic prescription trays is also disclosed.

Abstract: The present invention is directed to a tray handler for stacking and de-stacking ophthalmic prescription trays. The tray handler includes a plurality of spaced clamp assemblies defining a stack area along a conveyor, a lift plate, and first and second actuators. The lift plate is operably disposed within the stack area. The first actuator is operably associated with the clamp assemblies, which are inwardly and outwardly moveable relative the lift plate upon actuation of the first actuator. The second actuator is operably associated with the lift plate, which is vertically moveable within the stack area upon actuation of the second actuator. A controller is in communication with the first and second actuators and controls actuation thereof. A method of handling ophthalmic prescription trays is also disclosed.

Abstract: The present invention is directed to a tray handler for stacking and de-stacking ophthalmic prescription trays. The tray handler includes a plurality of spaced clamp assemblies defining a stack area along a conveyor, a lift plate, and first and second actuators. The lift plate is operably disposed within the stack area. The first actuator is operably associated with the clamp assemblies, which are inwardly and outwardly moveable relative the lift plate upon actuation of the first actuator. The second actuator is operably associated with the lift plate, which is vertically moveable within the stack area upon actuation of the second actuator. A controller is in communication with the first and second actuators and controls actuation thereof. A method of handling ophthalmic prescription trays is also disclosed.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: Systems and techniques for scheduling of data transmission to remote mobile units so as to provide at least an acceptably low level of delay. A scheduler computes an urgency value for each data stream serving a mobile unit and sets the urgency value equal to the highest urgency value of a data stream serving the mobile unit. The scheduler computes a scheduling priority for each mobile unit based on a computation that takes into account the urgency value of the mobile unit and schedules the highest priority mobile unit for service, selecting the highest priority data stream serving the mobile unit scheduled for transmission. The urgency value for a data stream depends on the sensitivity of the data stream to delay and the delay experienced by the data stream. Computation of the urgency value may take into account a delay limit associated with the data stream.

Abstract: The disclosed invention relates to a system and method for aligning reference marks defining the optical center or major reference point on a lens blank with a series of alignment marks, or “fiducials”. The fiducials comprise first and second alignment bars displayed on a display operably associated with a computer, and overlay the reference marks, also displayed on the display. The fiducials may be adjusted to accurately precisely align the lens blank.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.