Abstract: A method for heating reactor using a multi-function burner comprising feeding primary fuel through an annular channel, feeding oxygen through a central channel within the annular channel, and feeding an auxiliary fuel through a central lance within the central channel to produce a flame extending into a furnace having a temperature and a pressure; wherein the flow rate of the auxiliary fuel and oxygen are increased while maintaining an equivalence ratio below 1 to increase the temperature of the furnace; wherein after the furnace temperature exceeds the auto-ignition temperature of the primary fuel, increasing the flow rate of the primary fuel to increase the equivalence ratio to be greater than 1.

Abstract: A power module comprises a high frequency switching electronic power conditioner including stacked rectifier/filters, the stacked rectifier/filters generating stacked DC output voltages; and a vacuum electronic device coupled to the high frequency switching electronic power conditioner, the vacuum electronic device including components, each component receiving a respective DC output voltage of the stacked DC output voltages.

Abstract: A circuit assembly, including: an integrated circuit (IC) with a plurality of connection pads; a ball grid array (BGA) including a plurality of solder balls arranged in an array, where plurality of solder balls are configured to connect the plurality of connections pads to a plurality of connections pads on a PCB; and a BGA spacer configured to fit among the plurality of solder balls, wherein the BGA spacer has a width based upon a height and spacing of the plurality of solder balls and a height based upon a height and spacing of the plurality of solder balls and a minimum distance between the IC and the PCB to prevent shorting of adjacent solder balls.

Abstract: Certain aspects of the disclosure provide a method for transferring an achievement token, comprising: receiving a request to transfer an achievement token to a user; querying a smart contract to obtain a requirement associated with the achievement token; verifying, via a blockchain, the user completed the requirement, including retrieving user evidence associated with the requirement from the blockchain; and storing user evidence with a transaction history associated with the transfer of the achievement token to the user; and transferring, via the blockchain, the achievement token to the user.

Abstract: Certain aspects of the disclosure provide a method for transacting on a blockchain with an amount of user token for a transfer; an amount of user token for funding the transfer; and an amount of system token for paying a cost of the transfer, wherein the amount of user token for funding the transfer is determined to be equivalent to the amount of system token for paying the cost of the transfer; executing the transfer of user token; and reimbursing the amount of system token paid for the cost of the transfer.

Abstract: Certain aspects of the disclosure provide a method for transferring an achievement token, comprising: receiving a request to transfer an achievement token to a user; querying a smart contract to obtain a requirement associated with the achievement token; verifying, via a blockchain, the user completed the requirement, including retrieving user evidence associated with the requirement from the blockchain; and storing user evidence with a transaction history associated with the transfer of the achievement token to the user; and transferring, via the blockchain, the achievement token to the user.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: A printed circuit board (PCB) including: a first through hole; a first conductive pad on a surface of the PCB, wherein the first conductive pad has a first surface treatment; a reflowed solder layer on the first surface treatment; and a first clinch nut pressed into the first through hole, wherein the first clinch nut is pressed into contact with the solder layer to create electrical connectivity between the first clinch nut and the first conductive pad.

Abstract: A computing system implements a simulation environment for a graphic design system which creates a plurality of prototype screens that are individually renderable to simulate an application user interface. The computing system displays an initial prototype screen of the plurality of prototype screens, the initial prototype screen including a first set of interactive elements to navigate to a first set of prototype screens, and the computing system loads content associated with each prototype screen of the first set of prototype screens.

Abstract: A platform-based strength machine enables users to perform strength or lifting activities or exercises via moveable or configurable pull points. The strength machine can include tracks that facilitate the configuring of the positions of the pull points, handles that control operation of the strength machine and/or measure movements performed by a user, compact motors that facilitate various platform or load application configurations, safety systems for the strength machine, and other enhancements.

Abstract: Provided herein are mobile systems for sample processing. In some aspects, provided herein are mobile systems for sample processing and methods of use thereof for detection of pathogens in biological samples.

Abstract: A walking vehicle including a chassis and a plurality of wheel-leg components is described. The plurality of wheel-leg components are collectively operable to provide wheeled locomotion and walking locomotion.

Abstract: In one aspect, a vehicle is provided that includes i) a plurality of wheel-leg components and ii) a surround view imaging system for generating a surround view image of the vehicle. The plurality of wheel-leg components can operate to provide locomotion to the vehicle. The surround view image comprising a 360-degree, three-dimensional view of an environment surrounding the vehicle. The vehicle is configured to operate autonomously using the surround image view to control the locomotion of the plurality of the wheel-leg components.

Abstract: The present disclosure relates generally to methods of treating (i) a tumor (e.g., a solid tumor, an advanced solid tumor, a cancer), (ii) tumor-related weight loss, or (iii) tumor-related cachexia in a human patient, the method comprising administering to the human patient an anti-GDNF family receptor alpha-like (GFRAL) antibody, wherein the antibody inhibits GFRAL binding to Ret proto-oncogene (RET). The present disclosure also relates generally to methods of treating pancreatic cancer (e.g., an advanced pancreatic cancer, a metastatic pancreatic cancer, a pancreatic adenocarcinoma, a metastatic pancreatic adenocarcinoma, an MSI-H pancreatic cancer, a pancreatic ductal adenocarcinoma, a metastatic pancreatic ductal adenocarcinoma) in a human patient, comprising administering to the human patient (i) an anti-GFRAL antibody, wherein the antibody inhibits GFRAL binding to RET; (ii) paclitaxel; and (iii) gemcitabine.

Abstract: An apparatus (1100) for generating an itinerary a travelling object has travelled comprising an input unit configured to receive location information data (3001 . . . 300n) from a mobile computer (1200) of said travelling object; an itinerary generation unit (1113) which is configured to generate itinerary history data (1105) including a plurality of itinerary subsection information data 6001 . . . 600n); and an output unit (1115) which is configured to output at least one itinerary of the travelling object based on the itinerary subsection information data (6001 . . . 600n) and based on a weight value to the mobile computer (1200).

Abstract: Various implementations include an external fixation device for posterior pelvic compression that allows a pin engaged into one iliac bone to be pivoted relative to the pin engaged into the other iliac bone, allowing compression of the iliac bones toward each other and the interposed sacrum and for the relative positions of the pins to be held fixed relative to each other after the compression is set. The pin to be pivoted is engaged into the iliac bone closest to the source of the injury. And, the pins and bars of the fixation device are anteriorly coupled together, which gives the patient greater transportability, as well as maintenance of reduction that will assist in the definitive surgical intervention.

Abstract: Investigation of fine tissue structures, such as those in non-neural, non-osseous tissues or organs, is best performed in intact tissue. Described herein are compositions and methods for clearing tissues for subsequent three-dimensional analysis. The compositions referred to herein as tissue clearing compositions are composed of four core components: (1) a homogenizing agent such as N-methylglucamine, urea, thiourea, guanidine, guanidinium chloride, lithium perchlorate, ethylenediamine, and derivatives thereof; (2) a water-soluble adjusting agent such as iohexol, sodium thiosulfate, polyethylene glycol, and derivatives thereof; (3) a lipid-soluble adjusting agent such as 2,2?-thiodiethanol, propylene glycol, and derivatives thereof; and (4) a borate compound such as boric acid, tetraboric acid, disodium tetraborate, and derivatives thereof. The disclosed tissue clearing compositions are particularly suitable for use with non-neural, non-osseous tissues or organs.

Abstract: In various implementations, a fracture fixation system includes a plate, at least two distal screws, at least one fastener, and at least one wire. The plate has a proximal end, a distal end, and a longitudinal axis that extends between the proximal and distal ends. The plate also includes a distal end portion adjacent the distal end that defines at least two circular openings and an intermediate portion disposed between the proximal end portion and distal end portion. The intermediate portion defines at least one axially oriented elongated slot. The distal screws engage the respective circular openings and a distal end of the bone below a fracture of the bone. The fastener is slidably coupled to the axially oriented elongated slot to prevent movement laterally, rotationally, or angularly of the bone relative to the plate while allowing the proximal and distal portions of the bone to compress the fracture.

Abstract: Various implementations include an external fixation device for posterior pelvic compression that allows a pin engaged into one iliac bone to be pivoted relative to the pin engaged into the other iliac bone, allowing compression of the iliac bones toward each other and the interposed sacrum and for the relative positions of the pins to be held fixed relative to each other after the compression is set. The pin to be pivoted is engaged into the iliac bone closest to the source of the injury. And, the pins and bars of the fixation device are anteriorly coupled together, which gives the patient greater transportability, as well as maintenance of reduction that will assist in the definitive surgical intervention.