Abstract: An orthopedic instrument, comprising a pair of pivotally-connected arms, extending beyond a pivot axis of a first pivot; a pair of feet mounted to ends of the pair of pivotally-connected arms; and a quadrilateral linkage configured to maintain parallelism between the pair of feet over a range of angles and to selectively alter a distance between the pair of feet.

Abstract: An example flow cell includes a patterned substrate having an active region and a bonding region that at least partially surrounds the active region. The active region includes first depressions defined in a layer of the patterned substrate, surface chemistry positioned in the first depressions, and first interstitial regions surrounding the first depressions. The bonding region includes second depressions defined in the layer and second interstitial regions surrounding the second depressions. An adhesive is positioned over the second depressions and over the second interstitial regions. A cover is attached to the adhesive such that a flow channel is defined between a portion of the cover and the active region.

Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: Disclosed herein are systems, apparatuses, methods, and non-transitory computer readable media related to display constructs that can be fixed or movable. The display constructs can be configured to facilitate media display at opposite sides. The display constructs may be is at least partially transparent and can be viewed therethrough. Various interactive capabilities with the display construct are disclosed, as well as various installation component and kits. Further disclosed are wireless chargers embedded in fixtures and/or real assets of a facility.

Abstract: Disclosed herein are systems, apparatuses, methods, and non-transitory computer readable media related to a display construct coupled to a structure (e.g., a vision window). The structure can be a supportive structure such as a fixture. The display construct is configured to facilitate media display and is at least partially transparent. The vision window may be a tintable window, e.g., a window in which its tint is electrically controllable (e.g., an electrochromic window). Various interactive capabilities with the display construct are disclosed (e.g., via a touch screen).

Abstract: The disclosure relates to a system and a method for monitoring the state of optical elements of a device for laser material processing. According to the present disclosure a detailed monitoring of the state of optical elements of a device for laser material processing takes place by monitoring properties of laser radiation in the direction of an optical fiber or laser radiation entering a laser processing head connected to the laser source and these measurements, which can be performed during the processing process. The device according to the present disclosure has optical sensors for measuring the intensity and respective current laser power.

Abstract: Provided herein are mobile systems for sample processing. In some aspects, provided herein are mobile systems for sample processing and methods of use thereof for detection of pathogens in biological samples.

Abstract: In one aspect, a vehicle is provided that includes i) a plurality of wheel-leg components and ii) a surround view imaging system for generating a surround view image of the vehicle. The plurality of wheel-leg components can operate to provide locomotion to the vehicle. The surround view image comprising a 360-degree, three-dimensional view of an environment surrounding the vehicle. The vehicle is configured to operate autonomously using the surround image view to control the locomotion of the plurality of the wheel-leg components.

Abstract: A walking vehicle including a chassis and a plurality of wheel-leg components is described. The plurality of wheel-leg components are collectively operable to provide wheeled locomotion and walking locomotion.

Abstract: The present disclosure relates generally to methods of treating (i) a tumor (e.g., a solid tumor, an advanced solid tumor, a cancer), (ii) tumor-related weight loss, or (iii) tumor-related cachexia in a human patient, the method comprising administering to the human patient an anti-GDNF family receptor alpha-like (GFRAL) antibody, wherein the antibody inhibits GFRAL binding to Ret proto-oncogene (RET). The present disclosure also relates generally to methods of treating pancreatic cancer (e.g., an advanced pancreatic cancer, a metastatic pancreatic cancer, a pancreatic adenocarcinoma, a metastatic pancreatic adenocarcinoma, an MSI-H pancreatic cancer, a pancreatic ductal adenocarcinoma, a metastatic pancreatic ductal adenocarcinoma) in a human patient, comprising administering to the human patient (i) an anti-GFRAL antibody, wherein the antibody inhibits GFRAL binding to RET; (ii) paclitaxel; and (iii) gemcitabine.

Abstract: An apparatus (1100) for generating an itinerary a travelling object has travelled comprising an input unit configured to receive location information data (3001 . . . 300n) from a mobile computer (1200) of said travelling object; an itinerary generation unit (1113) which is configured to generate itinerary history data (1105) including a plurality of itinerary subsection information data 6001 . . . 600n); and an output unit (1115) which is configured to output at least one itinerary of the travelling object based on the itinerary subsection information data (6001 . . . 600n) and based on a weight value to the mobile computer (1200).

Abstract: Various implementations include an external fixation device for posterior pelvic compression that allows a pin engaged into one iliac bone to be pivoted relative to the pin engaged into the other iliac bone, allowing compression of the iliac bones toward each other and the interposed sacrum and for the relative positions of the pins to be held fixed relative to each other after the compression is set. The pin to be pivoted is engaged into the iliac bone closest to the source of the injury. And, the pins and bars of the fixation device are anteriorly coupled together, which gives the patient greater transportability, as well as maintenance of reduction that will assist in the definitive surgical intervention.

Abstract: Investigation of fine tissue structures, such as those in non-neural, non-osseous tissues or organs, is best performed in intact tissue. Described herein are compositions and methods for clearing tissues for subsequent three-dimensional analysis. The compositions referred to herein as tissue clearing compositions are composed of four core components: (1) a homogenizing agent such as N-methylglucamine, urea, thiourea, guanidine, guanidinium chloride, lithium perchlorate, ethylenediamine, and derivatives thereof; (2) a water-soluble adjusting agent such as iohexol, sodium thiosulfate, polyethylene glycol, and derivatives thereof; (3) a lipid-soluble adjusting agent such as 2,2?-thiodiethanol, propylene glycol, and derivatives thereof; and (4) a borate compound such as boric acid, tetraboric acid, disodium tetraborate, and derivatives thereof. The disclosed tissue clearing compositions are particularly suitable for use with non-neural, non-osseous tissues or organs.

Abstract: In various implementations, a fracture fixation system includes a plate, at least two distal screws, at least one fastener, and at least one wire. The plate has a proximal end, a distal end, and a longitudinal axis that extends between the proximal and distal ends. The plate also includes a distal end portion adjacent the distal end that defines at least two circular openings and an intermediate portion disposed between the proximal end portion and distal end portion. The intermediate portion defines at least one axially oriented elongated slot. The distal screws engage the respective circular openings and a distal end of the bone below a fracture of the bone. The fastener is slidably coupled to the axially oriented elongated slot to prevent movement laterally, rotationally, or angularly of the bone relative to the plate while allowing the proximal and distal portions of the bone to compress the fracture.

Abstract: Various implementations include an external fixation device for posterior pelvic compression that allows a pin engaged into one iliac bone to be pivoted relative to the pin engaged into the other iliac bone, allowing compression of the iliac bones toward each other and the interposed sacrum and for the relative positions of the pins to be held fixed relative to each other after the compression is set. The pin to be pivoted is engaged into the iliac bone closest to the source of the injury. And, the pins and bars of the fixation device are anteriorly coupled together, which gives the patient greater transportability, as well as maintenance of reduction that will assist in the definitive surgical intervention.

Abstract: A method for counting and aggregating a pre-determined number of articles includes: driving, by a conveyor, an article stream to move to an end of the conveyor in a single layer state; conveying the article stream in a periodic motion; after the articles in the article stream leave the conveyor, accurately counting the number of the articles; and when a total number of articles in a combination of temporary storage bin is the same as a target number, transporting all articles in the combination of temporary storage bin to a storage device. Article batches are separately delivered to different temporary storage bins, and the total number of articles in temporary storage bins in different combinations is calculated, so as to obtain with a combination in which the number of articles is the same as the target number. The operation efficiency is improved and the manufacturing cost of device is reduced.

Abstract: A system includes one or more processors to request access tokens from a token service computer, cache the access tokens and related information in a token cache, transmit the access tokens with a resource request to a resource server, and receive requested resources in response to the resource request. The resource server transmits representations of requested resources to computing devices having valid tokens. The access tokens and related information including credentials information and token metadata are stored in the token cache.

Abstract: A file system is provided with awareness of “streams” on an SSD to enable more efficient storage of files and other data on the SSD. The file system may be configured to receive a first request from an application to associate a file with a particular stream identifier available on a storage device, intercept one or more subsequent requests to write data to the file, associate the one or more subsequent requests with the stream identifier, and instruct a storage driver associated with the storage device to write the requested data to the identified stream.

Abstract: A method for counting and aggregating a pre-determined number of articles includes: driving, by a conveyor, an article stream to move to an end of the conveyor in a single layer state; conveying the article stream in a periodic motion; after the articles in the article stream leave the conveyor, accurately counting the number of the articles; and when a total number of articles in a combination of temporary storage bin is the same as a target number, transporting all articles in the combination of temporary storage bin to a storage device. Article batches are separately delivered to different temporary storage bins, and the total number of articles in temporary storage bins in different combinations is calculated, so as to obtain with a combination in which the number of articles is the same as the target number. The operation efficiency is improved and the manufacturing cost of device is reduced.

Abstract: A method for counting and aggregating a pre-determined number of articles includes: driving, by a conveyor, an article stream to move to an end of the conveyor in a single layer state; conveying the article stream in a periodic motion; after the articles in the article stream leave the conveyor, accurately counting the number of the articles; and when a total number of articles in a combination of temporary storage bin is the same as a target number, transporting all articles in the combination of temporary storage bin to a storage device. Article batches are separately delivered to different temporary storage bins, and the total number of articles in temporary storage bins in different combinations is calculated, so as to obtain with a combination in which the number of articles is the same as the target number. The operation efficiency is improved and the manufacturing cost of device is reduced.