Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

Abstract: Described herein are compounds of Formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

Abstract: Illustrative embodiments are directed to methods and computer systems for reporting unusual or anomalous usage a commodity by consumers. A computer system retrieves a set of usage-information datasets corresponding to a set of consumers, each dataset including past usage of the commodity during at least one of a completed billing period and a current usage of the commodity during the current billing period. The computer system establishes a set of report-trigger conditions for the current billing period, each of the report-trigger conditions corresponding to a consumer. The computer system may monitor usage or spending of the set of consumers to determine, for each consumer, whether an estimated usage established for each consumer fulfills the consumer's report-trigger condition. Once the report-trigger condition is fulfilled, the computer system outputs a report to the consumer.

Abstract: A change to a state of a particular managed server within an administrative domain is processed. The administrative domain includes a plurality of managed servers that use management instructions to configure management modules so that the configured management modules implement an administrative domain-wide management policy that comprises a set of one or more rules. A first description of the particular managed server is modified to indicate the particular managed server's changed state, thereby specifying a second description of the particular managed server. The unmodified first description is compared to the second description, thereby specifying a description change. A determination is made, based on the description change, regarding whether to update management instructions previously sent to the particular managed server.

Abstract: An exercise feedback system receives exercise data captured by client devices of users performing musculoskeletal exercises. The exercise feedback system may provide captured images to a client device of a physical trainer (PT) who remotely provides feedback on the users' exercise performances, for example, by labeling images as indicative of proper or improper musculoskeletal form. A PT may track multiple users using a central feed, which includes content displayed in an order based on ranking of users by a model. Additionally, the exercise feedback system may provide an augmented reality (AR) environment. For instance, an AR graphic indicating a target musculoskeletal form for an exercise is overlaid on a video feed displayed by a client device. Responsive to detecting that a user's form is aligned to the AR graphic, the exercise feedback system may notify the user and trigger the start of the exercise.

Abstract: A method is described that includes loading an array of content into a two-dimensional shift register. The two-dimensional shift register is coupled to an execution lane array. The method includes repeatedly performing a first sequence including: shifting with the shift register first content residing along a particular row or column into another parallel row or column where second content resides and performing operations with a particular corresponding row or column of the execution lane array on the first and second content. The method also includes repeatedly performing a second sequence including: shifting with the shift register content from a set of first locations along a resultant row or column that is parallel with the rows or columns of the first sequence into a corresponding set of second locations along the resultant row or column. The resultant row or column has values determined from the operations of the first sequence.

Abstract: Management instructions for a particular managed server within an administrative domain are generated according to an administrative domain-wide management policy that comprises a set of one or more rules. The administrative domain includes a plurality of managed servers. A determination is made regarding which rules within the set of rules are relevant to the particular managed server. Function-level instructions are generated based on the rules that were determined to be relevant. A determination is made regarding which managed servers within the plurality of managed servers are relevant to the particular managed server. The function-level instructions and information regarding the managed servers that were determined to be relevant are sent to the particular managed server.

Abstract: An exercise feedback system receives exercise data captured by client devices of users performing musculoskeletal exercises. The exercise feedback system may provide captured images to a client device of a physical trainer (PT) who remotely provides feedback on the users' exercise performances, for example, by labeling images as indicative of proper or improper musculoskeletal form. A PT may track multiple users using a central feed, which includes content displayed in an order based on ranking of users by a model. Additionally, the exercise feedback system may provide an augmented reality (AR) environment. For instance, an AR graphic indicating a target musculoskeletal form for an exercise is overlaid on a video feed displayed by a client device. Responsive to detecting that a user's form is aligned to the AR graphic, the exercise feedback system may notify the user and trigger the start of the exercise.

Abstract: Management instructions for a particular managed server within an administrative domain are generated according to an administrative domain-wide management policy that comprises a set of one or more rules. The administrative domain includes a plurality of managed servers. A determination is made regarding which rules within the set of rules are relevant to the particular managed server. Function-level instructions are generated based on the rules that were determined to be relevant. A determination is made regarding which managed servers within the plurality of managed servers are relevant to the particular managed server. The function-level instructions and information regarding the managed servers that were determined to be relevant are sent to the particular managed server.

Abstract: A reconfigurable neural network circuit is provided. The reconfigurable neural network circuit comprises an electronic synapse array including multiple synapses interconnecting a plurality of digital electronic neurons. Each neuron comprises an integrator that integrates input spikes and generates a signal when the integrated inputs exceed a threshold. The circuit further comprises a control module for reconfiguring the synapse array. The control module comprises a global final state machine that controls timing for operation of the circuit, and a priority encoder that allows spiking neurons to sequentially access the synapse array.

Abstract: Illustrative embodiments of the present invention are directed to methods and computer systems for reporting unusual or anomalous usage or spending of a commodity by consumers. A computer system retrieves a set of usage-information datasets corresponding to a set of consumers, each dataset including past usage of the commodity during at least one of a completed billing period and a current usage of the commodity during the current billing period. The computer system establishes a set of report-trigger conditions for the current billing period, each of the report-trigger conditions corresponding to a consumer. The computer system monitor usage or spending of the set of consumers to determine, for each consumer, whether an estimated usage established for each consumer fulfills the consumer's report-trigger condition. Once the report-trigger condition is fulfilled, the computer system outputs a report to the consumer.

Abstract: The present invention relates to RNAi molecules, and compositions thereof, comprising a 2? internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5? end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5? modified nucleotides that comprise, among other potential modifications, a 2? internucleoside linkage. The invention further relates to 5? modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.

Abstract: An apparatus is described. The apparatus includes an image processing unit. The image processing unit includes a plurality of stencil processor circuits each comprising an array of execution unit lanes coupled to a two-dimensional shift register array structure to simultaneously process multiple overlapping stencils through execution of program code. The image processing unit includes a plurality of sheet generators respectively coupled between the plurality of stencil processors and the network. The sheet generators are to parse input line groups of image data into input sheets of image data for processing by the stencil processors, and, to form output line groups of image data from output sheets of image data received from the stencil processors. The image processing unit includes a plurality of line buffer units coupled to the network to pass line groups in a direction from producing stencil processors to consuming stencil processors to implement an overall program flow.

Abstract: Systems and apparatus related to footwear including a modular lacing engine are discussed. In this example, the lace guide is deformable to assist in facilitating automated lace tightening. The lace guide can include a middle section, a first extension and a second extension. In this example, the lace guide can be configured to define a first route for a lace cable, the first route including receiving the lace cable along the first incoming lace axis and expelling the lace cable along the first outgoing lace axis. In this example, the lace guide can also deflect, in response to tension on the lace cable, resulting in defining a second route for the lace cable, the second route including receiving the lace cable along a second incoming lace axis and expelling the lace cable along a second outgoing lace axis.

Abstract: A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.

Abstract: A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.