Abstract: Automatic creation of product photoshoots that seamlessly combine real-life image portions and Artificial Intelligence (AI) generated portions. An input photograph of a product is received, and a background-removed version is generated. The image is fed into a Vision and Language Model (VLM) that generates textual attributes that pertain to the product. The textual attributes are fed into a Large Language Model (LLM), that generates a proposed textual prompt that will command an Image Diffusion unit to generate via Generative AI an image of a scenery that would be appropriate for showcasing that product. The AI-generated image is fed into an AI-based unit that detects and cures visual abnormalities or visual distortions, with AI-based blending and refinement. The method generates a high-definition abnormality-free and distortion-free output image that depicts the real-world product blended seamlessly within the Generative-AI scenery.

Abstract: Disclosed herein are methods for regulating expression of a gene located on an episomal vector in a subject in need thereof. In particular, methods include administering to the subject one or more gene editing agents that modify a region of the gene to thereby regulate the expression of the gene. Also disclosed are methods of administering to the subject a base editor system that effects a base alteration in a region of the gene or a region of an mRNA transcript of the gene to thereby regulate the expression of the gene.

Abstract: A contourable product for absorbing moisture includes a main sheet comprising an absorbent material. A number of sides of the main sheet is more than four, with the main sheet defined by a polygonal shape. The main sheet is movable between an unwrapped position and a wrapped position. In the unwrapped position, the main sheet is completely unfolded and substantially flat. In the wrapped position, the main sheet is contoured to secure to and wrap around a human head and extend around head hair of the human head.

Abstract: A cutting head for a tool for cutting a tubular member includes a cutting wheel. The cutting wheel has an aperture that extends therethrough. The aperture is centered on an axis of rotation of the cutting wheel. The cutting head further includes a blade axle disposed in the aperture such that the cutting wheel is rotatable relative to the blade axle about the axis of rotation. A portion of an outer surface of the blade axle has a texture formed thereon. The cutting head further includes a roller carriage having at least one roller configured to support a tubular member. The cutting head further includes a blade carriage that supports the blade axle. The blade carriage has a resilient member configured to bias the cutting wheel against the tubular member.

Abstract: A power tool accessory for cutting tubular members includes a housing, an input shaft configured to be coupled to a rotary power tool, a transmission, and a cutting head removably received in a front end of the housing. The transmission includes an input gear and an output gear with a first plurality of teeth. The cutting head has a central opening, a cutting blade protruding into the central opening, and a second plurality of teeth engaged by the first plurality of teeth. A clamp assembly coupled to the housing is moveable between a first position where the cutting head is removable from the housing and a second position where the cutting head is retained in the housing. The cutting head receives a tubular member in the central opening with the cutting blade engaging the tubular member to cut the tubular member as the cutting head rotates about the tubular member.

Abstract: The present disclosure provides for compounds of Formula (I), and pharmaceutically acceptable salts thereof, that inhibit the activity of TIPARP, wherein the variables have any of the values defined in the specification.

Abstract: A contourable product for absorbing moisture includes a main sheet comprising an absorbent material. A number of sides of the main sheet is more than four, with the main sheet defined by a polygonal shape. The main sheet is movable between an unwrapped position and a wrapped position. In the unwrapped position, the main sheet is completely unfolded and substantially flat. In the wrapped position, the main sheet is contoured to secure to and wrap around a human head and extend around head hair of the human head.

Abstract: Collagen compositions, methods for preparing those collagen compositions, and 3D constructs formed from those collagen compositions are provided. In particular, methods of isolating collagen that exhibits an enhanced rate of gelling, such collagen compositions, and 3D constructs formed from such collagen compositions are provided.

Abstract: In a method of inspecting a conduit fitting installed on a conduit end, the conduit fitting comprising a fitting body defining a central bore receiving the conduit end, a transducer is provided secured to a wall portion of the conduit end. The transducer is operated to apply a plurality of ultrasonic signals against an outer surface of the conduit end wall portion at a plurality of axial locations spaced apart from the central bore by a plurality of different distances, such that the plurality of ultrasonic signals are guided axially along the conduit end into the central bore of the conduit fitting and reflected axially back to the transducer. The reflected plurality of ultrasonic signals are evaluated to identify a condition of at least one of the conduit fitting and the conduit end.

Abstract: This application relates to a secondary token server and method of use thereof. The method includes receiving, by the secondary token server, a credential from a user device and corresponding to a credential owner. The method further includes validating, by the secondary token server, that the credential owner has ownership of the token, wherein validating comprises transmitting a request to a primary token server to authenticate the credential and the token. The method further includes generating, by the secondary credential server, an identifier that provides access to a certificate corresponding to the token and corresponding to a security component, wherein the security component rotates the certificate at a predetermined time interval. The method further includes providing, by the secondary token server, the identifier to the user device corresponding to the credential owner.

Abstract: Nucleic acids encoding modified FGF-21 polypeptides, optionally containing at least one non-codon encoding a naturally-encoded amino acid, and vectors and cells containing are provided. These nucleic acids can be used to express the modified FGF-21 polypeptide encoded thereby. The expressed FGF-21 polypeptides may be used as therapeutics, e.g., in the treatment of diseases associated with fibrosis.

Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: Techniques are described for managing licenses of Internet of Things devices. One embodiment includes receiving, at a network management system, a request to allocate a license to a first endpoint device. Real-time device metadata and state data for the first endpoint device are accessed. Embodiments select a license instance, from a plurality of license instances, to allocate to the first endpoint device, based at least in part on the real-time device metadata and state data for the first endpoint device. The selected license instance is assigned to the first endpoint device and at least an indication that a valid license has been assigned to the first endpoint device is transmitted to the first endpoint device.

Abstract: Polynucleotides including nucleic acids encoding ?-galactosidase A (GLA) are described. Also described are expression cassettes, vectors, cells, and cell lines containing the polynucleotides, as well as methods of using the polynucleotides to treat lysosomal storage disorders such as Fabry disease.

Abstract: A power tool accessory for cutting tubular members includes a housing, an input shaft configured to be coupled to a rotary power tool, a transmission, and a cutting head removably received in a front end of the housing. The transmission includes an input gear and an output gear with a first plurality of teeth. The cutting head has a central opening, a cutting blade protruding into the central opening, and a second plurality of teeth engaged by the first plurality of teeth. A clamp assembly coupled to the housing is moveable between a first position where the cutting head is removable from the housing and a second position where the cutting head is retained in the housing. The cutting head receives a tubular member in the central opening with the cutting blade engaging the tubular member to cut the tubular member as the cutting head rotates about the tubular member.

Abstract: Nucleic acids encoding C1 inhibitor are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat complement-mediated disorders, such as hereditary angioedema.