Abstract: Techniques are described for managing licenses of Internet of Things devices. One embodiment includes receiving, at a network management system, a request to allocate a license to a first endpoint device. Real-time device metadata and state data for the first endpoint device are accessed. Embodiments select a license instance, from a plurality of license instances, to allocate to the first endpoint device, based at least in part on the real-time device metadata and state data for the first endpoint device. The selected license instance is assigned to the first endpoint device and at least an indication that a valid license has been assigned to the first endpoint device is transmitted to the first endpoint device.

Abstract: To manage a plurality of parking spaces, one or more images are acquired, with each parking space appearing in at least one image. Periodically acquired images of occupancy and identity are used in directing a customer to a parked vehicle. Periodically acquired mages of just occupancy are used in controlling respective environmental aspects, such as illumination and ventilation, of the parking spaces. For these purposes, the images are classified automatically as “vacant” or “occupied”, and are displayed along with their classifications so that the classifications can be corrected manually.

Abstract: Techniques and computing devices are described that automatically caption content directly from audio data being output from content sources, unlike other captioning systems which often rely on information contained in audio signals being sent to speakers. The disclosed techniques and computing devices may analyze metadata to determine whether the audio data is suitable for captioning or whether the audio data is some other type of audio data. Responsive to identifying audio data for captioning, the disclosed techniques and computing devices can generate a description of audible sounds interpreted from the audio data, providing for the automatic captioning of content and making audible content accessible to many users who have difficulty hearing or are otherise unable to listen to content.

Abstract: The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: Systems and methods related to intelligent typing and responses using eye-gaze technology are disclosed herein. In some example aspects, a dwell-free typing system is provided to a user typing with eye-gaze. A prediction processor may intelligently determine the desired word or action of the user. In some aspects, the prediction processor may contain elements of a natural language processor. In other aspects, the systems and methods may allow quicker response times from applications due to application of intelligent response algorithms. For example, a user may fixate on a certain button within a web-browser, and the prediction processor may present a response to the user by selecting the button in the web-browser, thereby initiating an action. In other example aspects, each gaze location may be associated with a UI element. The gaze data and associated UI elements may be processed for intelligent predictions and suggestions.

Abstract: To manage a plurality of parking spaces, one or more images are acquired, with each parking space appearing in at least one image. Periodically acquired images of occupancy and identity are used in directing a customer to a parked vehicle. Periodically acquired images of just occupancy are used in controlling respective environmental aspects, such as illumination and ventilation, of the parking spaces. For these purposes, the images are classified automatically as “vacant” or “occupied”, and are displayed along with their classifications so that the classifications can be corrected manually.

Abstract: A tissue or organ replacement includes a tissue-engineered construct that includes one or more bio ink compositions and a biocompatible support structure. The support structure includes one or more external supports, one or more internal supports, or combinations thereof of a biocompatible material. The composition has a three-dimensional (3D) shape, and the biocompatible material is present in an amount of about 1% to about 100% by weight of the biocompatible support structure.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: Techniques for configuring a device with a security context using a security context distribution service are provided. One embodiment receives, from a first device operating on a first network, a request for a security context for the first device, where the request includes a public certificate for the first device. The request is decrypted, and the public certificate is validated. A set of device requirements are determined based on a unique identifier for the first device and device claim information associated with the first device. Embodiments generate a response message that contains at least one Transport Layer Security (TLS) certificate associated with the first network, based on the set of device requirements, where the response message is encrypted using a public key associated with the first device. The response is message is transmitted to the first device.

Abstract: Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.

Abstract: Systems and methods disclosed herein relate to assigning dynamic eye-gaze dwell-times. Dynamic dwell-times may be tailored to the individual user. For example, a dynamic dwell-time system may be configured to receive data from the user, such as the duration of time the user takes to execute certain actions within applications (e.g., read a word suggestion before actually selecting it). The dynamic dwell-time system may also prevent users from making unintended selections by providing different dwell times for different buttons. Specifically, on a user interface, longer dwell times may be established for the critical keys (e.g., “close” program key, “send” key, word suggestions, and the like) and shorter dwell times may be established for the less critical keys (e.g., individual character keys on a virtual keyboard, spacebar, backspace, and the like).

Abstract: Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.

Abstract: Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts, pharmaceutical compositions, uses, and methods of use thereof are provided.

Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.

Abstract: A method for depth mapping includes receiving optical radiation reflected from multiple points on an object and processing the received optical radiation to generate depth data including multiple candidate depth coordinates for each of a plurality of pixels and respective measures of confidence associated with the candidate depth coordinates. One of the candidate depth coordinates is selected at each of the plurality of the pixels responsively to the respective measures of confidence. A depth map of the object is output, including the selected one of the candidate depth coordinates at each of the plurality of the pixels.

Abstract: The present invention relates to combinations and methods based on Baclofen and Acamprosate for the treatment of Alzheimer's disease or Alzheimer's related disorders in patients who do not respond to an inhibitor of acetylcholinesterase, typically in patients treated with an inhibitor of acetylcholinesterase and who have lost responsiveness to said inhibitor of acetylcholinesterase.

Abstract: Systems and methods disclosed herein relate to assigning dynamic eye-gaze dwell-times. Dynamic dwell-times may be tailored to the individual user. For example, a dynamic dwell-time system may be configured to receive data from the user, such as the duration of time the user takes to execute certain actions within applications (e.g., read a word suggestion before actually selecting it). The dynamic dwell-time system may also prevent users from making unintended selections by providing different dwell times for different buttons. Specifically, on a user interface, longer dwell times may be established for the critical keys (e.g., “close” program key, “send” key, word suggestions, and the like) and shorter dwell times may be established for the less critical keys (e.g., individual character keys on a virtual keyboard, spacebar, backspace, and the like).