Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: The present disclosure relates to improvements in turbocharger efficiency and more particularly to a method and system for estimating the efficiency loss of a turbocharger. The method comprises the steps of monitoring a plurality of operating parameters and determining a compressor exit temperature according to a first calibration map based on these operating parameters. An estimate of instantaneous turbocharger efficiency loss according to a second calibration map is then determined, based on the compressor exit temperature. The instantaneous turbocharger efficiency loss is used to determine an estimate of cumulative turbocharger efficiency loss during engine service. The estimate of cumulative turbocharger efficiency loss is compared with a first predetermined efficiency loss threshold and a first signal is generated if the first predetermined efficiency loss threshold is exceeded.

Abstract: A method for monitoring driving behavior of a vehicle includes obtaining first information including values related to driving operations of a vehicle based on sensors and obtaining a geographical location or a vehicle type of the vehicle. The method also includes extracting second information including values related to operations of vehicles associated with the vehicle type of the vehicle or the geographical location of the vehicle and determining whether there is a difference between the first information and the second information. The method further includes instructing the vehicle to adjust driving operations in response to determining that there is the difference between the first information and the second information.

Abstract: A server system stores a list of trusted users that are authorized to access a first electronic device's shared listening sessions. While the first electronic device is hosting a shared listening session playing back media on a second electronic device, the server system receives, from a third electronic device, a request that includes an identifier of the second electronic device. In response to the first request and in accordance with a determination that the third electronic device is associated with a user that is on the list of trusted users, the server system automatically transmits, to the third electronic device, a session identifier for the first shared listening session. The server system receives, from the third electronic device, a request to join the shared listening session, in response to the second request, provides, to the third electronic device, access to control media playback of the first listening session.

Abstract: A vibrating fork liquid level switch includes a vibrating fork assembly arranged to vibrate at a first frequency when in contact with a process fluid and at a second frequency when in contact with air. A drive circuit connected to the vibrating fork assembly is configured to drive the vibrating fork assembly into oscillation. Sense circuitry senses an oscillation frequency of the vibrating fork assembly. Output circuitry provides a first output when the sensed oscillation is at the first frequency and a second output when the sensed oscillation is at the second frequency. Control circuitry controls power applied to the vibrating fork assembly by the drive circuit between a first and a second power level. Verification circuitry verifies the oscillation frequency of the vibrating fork assembly when power applied to the vibrating fork assembly by the drive circuitry is changed.

Abstract: A vibrating fork liquid level switch includes a vibrating fork assembly arranged to vibrate at a first frequency when in contact with a process fluid and at a second frequency when in contact with air. A drive circuit connected to the vibrating fork assembly is configured to drive the vibrating fork assembly into oscillation. Sense circuitry senses an oscillation frequency of the vibrating fork assembly. Output circuitry provides a first output when the sensed oscillation is at the first frequency and a second output when the sensed oscillation is at the second frequency. Control circuitry controls power applied to the vibrating fork assembly by the drive circuit between a first and a second power level. Verification circuitry verifies the oscillation frequency of the vibrating fork assembly when power applied to the vibrating fork assembly by the drive circuitry is changed.

Abstract: Methods and apparatus to adjust vehicle suspension damping are disclosed herein. An example apparatus includes interface circuitry, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to determine a terrain condition based on first wheel position data of a vehicle and second wheel position data of the vehicle, determine a damping command based on the terrain condition, and adjust a suspension of the vehicle based on the damping command.

Abstract: Methods and apparatus to adjust vehicle suspension damping are disclosed herein. An example apparatus includes memory and at least one processor to execute computer readable instructions to obtain wheel position information and vehicle speed information from sensors associated with wheels of a vehicle, the wheel position information including first wheel position data and second wheel position data, determine a terrain condition based on a greater of the first wheel position data and the second wheel position data, determine a compression damping command based on the terrain condition and the vehicle speed information, and adjust a damping system of the vehicle based on the compression damping command.

Abstract: The present disclosure relates to improvements in turbocharger efficiency and more particularly to a method and system for estimating the efficiency loss of a turbocharger. The method comprises the steps of monitoring a plurality of operating parameters and determining a compressor exit temperature according to a first calibration map based on these operating parameters. An estimate of instantaneous turbocharger efficiency loss according to a second calibration map is then determined, based on the compressor exit temperature. The instantaneous turbocharger efficiency loss is used to determine an estimate of cumulative turbocharger efficiency loss during engine service. The estimate of cumulative turbocharger efficiency loss is compared with a first predetermined efficiency loss threshold and a first signal is generated if the first predetermined efficiency loss threshold is exceeded.

Abstract: The present disclosure relates to antimicrobial compositions, particularly to antibiotic compositions; to methods for identification of antimicrobial compositions involving in silico prediction of antimicrobial activity; and to use of antimicrobial compositions and methods.

Abstract: A server system stores a list of trusted users that are authorized to access a first electronic device's shared listening sessions. While the first electronic device is hosting a shared listening session playing back media on a second electronic device, the server system receives, from a third electronic device, a request that includes an identifier of the second electronic device. In response to the first request and in accordance with a determination that the third electronic device is associated with a user that is on the list of trusted users, the server system automatically transmits, to the third electronic device, a session identifier for the first shared listening session. The server system receives, from the third electronic device, a request to join the shared listening session, in response to the second request, provides, to the third electronic device, access to control media playback of the first listening session.

Abstract: A server system receives from a first electronic device, an indication that the first electronic device has shared a first listening session playing back on a second electronic device. The server system receives, from a third electronic device, a first request for one or more shared listening sessions playing back on the second electronic device. The request includes an identifier of the second electronic device. In response to the first request, the server system transmits, to the third electronic device, a session identifier for the first listening session. The server system receives, form the third electronic device, a second request to join the first listening session using the session identifier for the first listening session. The server system then provides, to the third electronic device, access to the first listening session playing back on the second electronic device.

Abstract: A server system receives from a first electronic device, an indication that the first electronic device has shared a first listening session playing back on a second electronic device. The server system receives, from a third electronic device, a first request for one or more shared listening sessions playing back on the second electronic device. The request includes an identifier of the second electronic device. In response to the first request, the server system transmits, to the third electronic device, a session identifier for the first listening session. The server system receives, form the third electronic device, a second request to join the first listening session using the session identifier for the first listening session. The server system then provides, to the third electronic device, access to the first listening session playing back on the second electronic device.

Abstract: Methods and apparatus to adjust vehicle suspension damping are disclosed herein. An example apparatus includes memory and at least one processor to execute computer readable instructions to obtain wheel position information and vehicle speed information from sensors associated with wheels of a vehicle, the wheel position information including first wheel position data and second wheel position data, determine a terrain condition based on a greater of the first wheel position data and the second wheel position data, determine a compression damping command based on the terrain condition and the vehicle speed information, and adjust a damping system of the vehicle based on the compression damping command.

Abstract: Methods and apparatus to adjust vehicle suspension damping are disclosed herein. An example apparatus includes a sensor interface to obtain wheel position information and vehicle speed information from sensors associated with wheels of a vehicle and obtain throttle position information. The apparatus further includes a parameter analyzer to determine a compression damping command based on the wheel position information, the vehicle speed information, and the throttle position information and an instruction generator to adjust a damping system of the vehicle based on the compression damping command.

Abstract: An earphone with a first acoustic cavity, an electro-acoustic transducer configured to deliver acoustic energy into the first acoustic cavity, and a port that acoustically couples the first acoustic cavity to a different volume, wherein the port comprises a series of through-holes that are open to the first acoustic cavity and the different volume.

Abstract: An earphone with a first acoustic cavity, an electro-acoustic transducer configured to deliver acoustic energy into the first acoustic cavity, and a port that acoustically couples the first acoustic cavity to a different volume, wherein the port comprises a series of through-holes that are open to the first acoustic cavity and the different volume.

Abstract: Methods and apparatus to adjust vehicle suspension damping are disclosed herein. An example apparatus includes a sensor interface to obtain wheel position information and vehicle speed information from sensors associated with wheels of a vehicle and obtain throttle position information. The apparatus further includes a parameter analyzer to determine a compression damping command based on the wheel position information, the vehicle speed information, and the throttle position information and an instruction generator to adjust a damping system of the vehicle based on the compression damping command.

Abstract: A control system is provided for thermal management of an aftertreatment device in an engine that is provided in an enclosure. The engine has a cooling fan that is operable in a first direction to cool said engine. The fan is also operable in a reverse direction opposite to the first direction. The control system includes a first temperature sensor that measures a temperature of the engine or the enclosure. The control system further includes a second temperature sensor that measures a temperature of the aftertreatment device. The control system also includes a processor that is coupled to the first and second temperature sensors. The processor is configured to issue control signals, based on whether regeneration is required by the aftertreatment device or not, for selectively controlling a direction of operation associated with the cooling fan.