Abstract: The present invention provides methods of treating cancer using a STAT3 double-stranded, cyclic oligonucleotide decoy in combination with an immune checkpoint inhibitor.

Abstract: A relofted, spunbonded nonwoven web exhibiting a solidity of from less than 8.0%, to at least 3.0%, and exhibiting a Quality Factor of at least 0.30. Methods of making a relofted web; and, methods of using a relofted web as an air-filtration web, e.g. as a filter media or a layer thereof.

Abstract: Provided herein are acoustic articles (100) that include a porous layer (102) and heterogeneous filler (104) received in the porous layer. The heterogeneous filler is substantially non-porous and present in an amount of from 0.25% to 7% by volume relative to the total volume of the porous layer and has a specific surface area of from 0.01 m2/g to 1 m2/g. The acoustic article has a flow resistance of from 500 MKS Rayls to 12,000 MKS Rayls.

Abstract: A composite fabric includes a nonwoven fabric layer having non-bonded areas and a structured film layer discontinuously bonded to the nonwoven fabric layer. The discontinuously bonded nonwoven fabric layer and the structured film layer share an overlapping area with at least one set of coincident bond sites. The discontinuously bonded nonwoven fabric does not have another bonding pattern in the overlapping area distinct from the at least one set of coincident bond sites. A method of forming a composite fabric is also described. The method includes forming a fiber layer including a mat of at least partially unconsolidated fibers, positioning a structured film layer and the fiber layer such that they overlap, and discontinuously bonding the mat into a discontinuously bonded nonwoven fabric while simultaneously bonding the structured film layer to the nonwoven fabric layer. An apparatus for forming a composite fabric is also described.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes an insert retainer having a retainer head and a retainer pin. The retainer pin has an upper section extending below the retainer head and a grooved center section below the upper section. A valve is centered on the upper section of the retainer pin. An insert is located on the valve. A guide has a central portion centered on the upper section of the retainer pin and four legs extending from the central portion. A collar has a flange and a collar body that is swaged into the center section of the retainer pin.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes an insert retainer having a retainer head and a retainer pin. The retainer pin has an upper section extending below the retainer head and a grooved center section below the upper section. A valve is centered on the upper section of the retainer pin. An insert is located on the valve. A guide has a central portion centered on the upper section of the retainer pin and four legs extending from the central portion. A collar has a flange and a collar body that is swaged into the center section of the retainer pin.

Abstract: A relofted, spunbonded nonwoven web exhibiting a solidity of from less than 8.0%, to at least 3.0%, and exhibiting a Quality Factor of at least 0.30. Methods of making a relofted web; and, methods of using a relofted web as an air-filtration web, e.g. as a filter media or a layer thereof.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes an insert retainer having a retainer head and a retainer pin. The retainer pin has an upper section extending below the retainer head and a grooved center section below the upper section. A valve is centered on the upper section of the retainer pin. An insert is located on the valve. A guide has a central portion centered on the upper section of the retainer pin and four legs extending from the central portion. A collar has a flange and a collar body that is swaged into the center section of the retainer pin.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin having a retaining cap on its upper end. Located on the retaining pin are an insert retainer, an insert beneath the insert retainer, a valve beneath the insert, and a guide beneath the valve. The guide has a generally truncated pyramid shape, and a central portion on its upper end. The central portion is centered on the retaining pin. The retaining pin has an expanded lower end to secure the valve assembly together.

Abstract: A web of nonwoven fabric suitable for, e.g., the loop portion of a hook-and-loop fastening system. The method for making this material relies on differential shrinkage of different layers to cause the loops to self-form. The method is robust and simpler than that previously used for similar constructions.

Abstract: The present disclosure relates to electrode assemblies, membrane-electrode assemblies and electrochemical cells and liquid flow batteries produced therefrom. The electrode and membrane-electrode assemblies include (i) a porous electrode having a first major surface with a first surface area, Ae, an opposed second major surface and a plurality of voids; (ii) a discontinuous transport protection layer, comprising polymer, disposed on the first major surface and having a cross-sectional area, Ap, substantially parallel to the first major surface; and (iii) an interfacial region wherein the interfacial region includes a portion of the polymer embedded in at least a portion of the plurality of voids, a portion of the porous electrode embedded in a portion of the polymer or a combination thereof; and wherein 0.02Ae?Ap?0.85Ae and the porous electrode and discontinuous transport protection layer form an integral structure.

Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.

Abstract: A composite fabric includes a nonwoven fabric layer having non-bonded areas and a structured film layer discontinuously bonded to the nonwoven fabric layer. The discontinuously bonded nonwoven fabric layer and the structured film layer share an overlapping area with at least one set of coincident bond sites. The discontinuously bonded nonwoven fabric does not have another bonding pattern in the overlapping area distinct from the at least one set of coincident bond sites. A method of forming a composite fabric is also described. The method includes forming a fiber layer including a mat of at least partially unconsolidated fibers, positioning a structured film layer and the fiber layer such that they overlap, and discontinuously bonding the mat into a discontinuously bonded nonwoven fabric while simultaneously bonding the structured film layer to the nonwoven fabric layer. An apparatus for forming a composite fabric is also described.

Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin having a retaining cap on its upper end. Located on the retaining pin are an insert retainer, an insert beneath the insert retainer, a valve beneath the insert, and a guide beneath the valve. The guide has a generally truncated pyramid shape, and a central portion on its upper end. The central portion is centered on the retaining pin. The retaining pin has an expanded lower end to secure the valve assembly together.

Abstract: The present invention discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin, a guide on the retaining pin, a valve on the retaining pin, an insert on the retaining pin, a retainer above the insert on the retaining pin, and a retainer cap inertia welded to the end of the retaining pin. In a particular embodiment, the guide component is stamped and folded to create the desired shape.

Abstract: A composite nonwoven fabric and articles comprising the composite nonwoven fabric are provided. The composite nonwoven fabric comprises a population of meltblown fibers comprising an aliphatic polyether thermoplastic polyurethane polymer having at least about 80% (by weight) polyalkylene oxide and a population of staple fibers intermixed and entangled therewith.