Abstract: A composite fabric includes a nonwoven fabric layer having non-bonded areas and a structured film layer discontinuously bonded to the nonwoven fabric layer. The discontinuously bonded nonwoven fabric layer and the structured film layer share an overlapping area with at least one set of coincident bond sites. The discontinuously bonded nonwoven fabric does not have another bonding pattern in the overlapping area distinct from the at least one set of coincident bond sites. A method of forming a composite fabric is also described. The method includes forming a fiber layer including a mat of at least partially unconsolidated fibers, positioning a structured film layer and the fiber layer such that they overlap, and discontinuously bonding the mat into a discontinuously bonded nonwoven fabric while simultaneously bonding the structured film layer to the nonwoven fabric layer. An apparatus for forming a composite fabric is also described.

Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically.

Abstract: The present disclosure discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin having a retaining cap on its upper end. Located on the retaining pin are an insert retainer, an insert beneath the insert retainer, a valve beneath the insert, and a guide beneath the valve. The guide has a generally truncated pyramid shape, and a central portion on its upper end. The central portion is centered on the retaining pin. The retaining pin has an expanded lower end to secure the valve assembly together.

Abstract: The present invention discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin, a guide on the retaining pin, a valve on the retaining pin, an insert on the retaining pin, a retainer above the insert on the retaining pin, and a retainer cap inertia welded to the end of the retaining pin. In a particular embodiment, the guide component is stamped and folded to create the desired shape.

Abstract: A composite nonwoven fabric and articles comprising the composite nonwoven fabric are provided. The composite nonwoven fabric comprises a population of meltblown fibers comprising an aliphatic polyether thermoplastic polyurethane polymer having at least about 80% (by weight) polyalkylene oxide and a population of staple fibers intermixed and entangled therewith.

Abstract: The present invention discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin, a guide on the retaining pin, a valve on the retaining pin, an insert on the retaining pin, a retainer above the insert on the retaining pin, and a retainer cap inertia welded to the end of the retaining pin. In a particular embodiment, the guide component is stamped and folded to create the desired shape.

Abstract: The present invention discloses a multi-component valve system for use in pumps such as fracking pumps for use in subterranean resource production. The assembly includes a retaining pin, a guide on the retaining pin, a valve on the retaining pin, an insert on the retaining pin, a retainer above the insert on the retaining pin, and a retainer cap inertia welded to the end of the retaining pin. In a particular embodiment, the guide component is stamped and folded to create the desired shape.

Abstract: Predetermined non-uniform residual compressive stress distributions are induced in the spring wire of metallic coil springs. The residual compressive stress tends to reduce deleterious effects of both fatigue and coil binding impacts on spring performance. Transverse cross-sections of coil spring wire reveal non-uniform distributions of residual compressive stress that exhibit substantial symmetry about various transverse axes, including axes connecting potential or actual opposing coil binding contact points on the spring wire surface. Residual compressive stress in coil spring wire of the present invention may also vary in a predetermined manner when measured longitudinally along the coil spring wire.

Abstract: A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electroporated by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors.

Abstract: A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electrophoresed by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors.

Abstract: A food waste mixing and heat treating vehicle used in feeding hogs has a wheeled chassis. A mixing drum is rotatably mounted on the chassis having an inner wall forming a mixing and heating cavity and having an opening into the cavity. Means are provided for rotating the mixing drum. Two opposing helical mixing blades are each affixed along the inner wall from the opening into the cavity for drawing the food waste into the cavity from the opening, mixing the food waste in the cavity and evacuating the food waste out of the cavity through the opening. Steam injecting means are along the inner wall within the cavity for injecting steam through the food waste for heat treating the food waste for later feeding hogs after the food waste has cooled. The method involves the collecting, heat treating and feeding of the food waste to hogs with the vehicle. The hog lot for raising and feeding hogs the heat treated food waste comprises a plurality of adjacent elongate pens with a juxtaposed feed pen there along.

Abstract: A method of prestressing the working surface of pressure chambers or cylinders comprising the steps of first shot peening their working surfaces to form compressive residual stresses, and then applying fluid pressure at a predetermined magnitude to cause tensile stresses in the working surfaces. The magnitude of compressive residual stresses established on their outer working surfaces is made substantially equal to the tensile stress applied to these surfaces during the pressure phase of the process.

Abstract: A body restraining device for restraining movement of the body of a subject which comprises a flexible strap construction having Velcro-covered segments at the ends thereof, and also having an enlarged section of the strap construction thicker than the thickness of the strap itself, the enlarged strap section acting to prevent the strap from slipping through the space between an automobile door and the door jamb when the door is closed. The device is particularly adapted for restraining the movement of prisoners who are positioned in the jump seat of a police car or the like.