Patents by Inventor Daniel F. Voytas

Daniel F. Voytas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Potatoes with reduced granule-bound starch synthase
    Patent number: 10301637
    Abstract: Materials and methods for making plants (e.g., Solanum varieties) with decreased levels of amylose are provided herein. The methods can include making mutations in the gene encoding granule bound starch synthase (GBSS), where the mutations are induced using a rare-cutting endonuclease.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 28, 2019
    Assignee: CELLECTIS
    Inventors: Benjamin Clasen, Daniel F. Voytas, Feng Zhang
  • GLYPHOSATE TOLERANT PLANTS HAVING MODIFIED 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE GENE REGULATION
    Publication number: 20190017067
    Abstract: This document provides methods and materials related to plants (e.g., nontransgenic plants) that are tolerant to glyphosate-based herbicides. For example, glyphosate tolerant plants can have an altered expression profile (e.g., increased expression levels) of a 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene (e.g., a modified EPSPS gene).
    Type: Application
    Filed: January 12, 2017
    Publication date: January 17, 2019
    Inventors: Aaron W. Hummel, Daniel F. Voytas, Rebecca Bart, Nigel Taylor, Raj Deepika Chauhan
  • Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
    Patent number: 10113162
    Abstract: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD2-1A and FAD2-1B genes.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 30, 2018
    Assignee: CELLECTIS
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, William Haun
  • TAL EFFECTOR-MEDIATED DNA MODIFICATION
    Publication number: 20180051267
    Abstract: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
    Type: Application
    Filed: October 5, 2017
    Publication date: February 22, 2018
    Inventors: Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang
  • TAL EFFECTOR-MEDIATED DNA MODIFICATION
    Publication number: 20180051266
    Abstract: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 22, 2018
    Inventors: Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang
  • Gene targeting methods and tools
    Patent number: 9850497
    Abstract: Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to subject (e.g., patient), as well as a set of tools (TALENs and gene targeting vectors) to accomplish such method.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: December 26, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Rita Perlingeiro, Michael Kyba, Fabrizio Rinaldi, Daniel F. Voytas
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20170258024
    Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: October 25, 2016
    Publication date: September 14, 2017
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • TAL effector-mediated DNA modification
    Patent number: 9758775
    Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 12, 2017
    Assignees: Regents of the University of Minnesota, Iowa State University Research Foundation, Inc.
    Inventors: Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang
  • METHODS FOR USING A 5'-EXONUCLEASE TO INCREASE HOMOLOGOUS RECOMBINATION IN EUKARYOTIC CELLS
    Publication number: 20170175140
    Abstract: Provided herein are materials and methods for gene editing in eukaryotic cells (e.g., plant cells) by homologous recombination, including materials and methods for boosting the frequency of homologous recombination through the application of a 5?-exonuclease for end-processing of DNA double-strand breaks.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 22, 2017
    Inventors: Aaron W. Hummel, Javier Gil Humanes, Daniel F. Voytas
  • CONFERRING RESISTANCE TO GEMINIVIRUSES IN PLANTS USING CRISPR/CAS SYSTEMS
    Publication number: 20160237451
    Abstract: Materials and methods for conferring geminivirus resistance to plants, and particularly to materials and methods for using CRISPR/Cas systems to confer resistance to geminiviruses to plants.
    Type: Application
    Filed: September 30, 2014
    Publication date: August 18, 2016
    Inventors: Daniel F. Voytas, Nicholas J. Baltes, Aaron W. Hummel
  • TALEN-based gene correction
    Patent number: 9393257
    Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: July 19, 2016
    Assignee: Regents of the University of Minnesota
    Inventors: Mark J. Osborn, Jakub Tolar, Bruce Blazar, Daniel F. Voytas
  • METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS
    Publication number: 20160145631
    Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 26, 2016
    Inventors: Daniel F. Voytas, Feng Zhang, Jin Li, Thomas Stoddard, Song Luo
  • BRASSICA ENGINEERED TO CONFER HERBICIDE TOLERANCE
    Publication number: 20160138040
    Abstract: Materials and methods for making plants (e.g., Brassica varieties) with tolerance to ALS-inhibiting herbicides are provided herein. The methods can include making mutations in the gene encoding acetolactate synthase (ALS)/acetohydroxyacid synthase (AHAS), where the mutations are induced using a rare-cutting endonuclease and a donor matrix.
    Type: Application
    Filed: November 13, 2015
    Publication date: May 19, 2016
    Inventors: Daniel F. Voytas, Thomas Stoddard, Feng Zhang, Luc Mathis
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20160037742
    Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: December 20, 2013
    Publication date: February 11, 2016
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • POTATOES WITH REDUCED GRANULE-BOUND STARCH SYNTHASE
    Publication number: 20150368659
    Abstract: Materials and methods for making plants (e.g., Solanum varieties) with decreased levels of amylose are provided herein. The methods can include making mutations in the gene encoding granule bound starch synthase (GBSS), where the mutations are induced using a rare-cutting endonuclease.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Inventors: Benjamin Clasen, Daniel F. Voytas, Feng Zhang
  • COUPLING HERBICIDE RESISTANCE WITH TARGETED INSERTION OF TRANSGENES IN PLANTS
    Publication number: 20150291967
    Abstract: The present invention relates to methods allowing the targeted insertion of transgenes into a plant genome at desired loci by using homologous recombination combined with rare-cutting endonucleases without the need of inserting an exogenous selectable marker.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 15, 2015
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Song Luo
  • PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS
    Publication number: 20150272076
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 1, 2015
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • GENE TARGETING IN PLANTS USING DNA VIRUSES
    Publication number: 20150225734
    Abstract: Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases.
    Type: Application
    Filed: June 19, 2013
    Publication date: August 13, 2015
    Applicant: Regents of the University of Minnesota
    Inventors: Daniel F. Voytas, Nicholas Baltes
  • ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
    Publication number: 20150167000
    Abstract: Materials and methods for gene targeting using Clustered Regularly Interspersed Short Palindromic Repeats/CRISPR-associated (CRISPR/Cas) systems are provided herein.
    Type: Application
    Filed: February 24, 2015
    Publication date: June 18, 2015
    Inventors: Daniel F. Voytas, Paul Atkins, Nicholas J. Baltes
  • GENE TARGETING METHODS AND TOOLS
    Publication number: 20150125429
    Abstract: Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to subject (e.g., patient), as well as a set of tools (TALENs and gene targeting vectors) to accomplish such method.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 7, 2015
    Inventors: Rita Perlingeiro, Michael Kyba, Fabrizio Rinaldi, Daniel F. Voytas